# Permease

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{{Short description|Class of proteins allowing diffusion of molecules in or out of a cell}}
The '''permeases''' are [membrane transport protein](/source/membrane_transport_protein)s, a class of multipass transmembrane proteins that allow the diffusion of a specific molecule in or out of the [cell](/source/cell_(biology)) in the direction of a [concentration gradient](/source/concentration_gradient), a form of [facilitated diffusion](/source/facilitated_diffusion). <ref>{{Cite web|url=http://www.ks.uiuc.edu/Research/lacY/|title = Substrate Transport in Lactose Permease}}</ref>

The permease binding is the first step of translocation. LacY protein from Escherichia coli is an example of a permease.<ref>{{Cite book|title=Fundamental laboratory approaches for biochemistry and biotechnology|last1=J.|first1=Ninfa, Alexander|last2=P.|first2=Ballou, David|date=2004|publisher=Wiley|isbn=1891786008|oclc=633862582}}</ref>

==See also==

* [Lactose permease](/source/Lactose_permease)
* [Beta-galactoside permease](/source/Beta-galactoside_permease)
It was originally discovered in the 1930s by Joy Adames {{Citation needed|date=March 2025|reason=Typo? I can't find any reference for this and thought Permease was connected to Jacques Monod.}}. It is a transporter protein that helps in various aspects of cellular life including DNA replication, translation of RNA, and diffusion.
* [Amino acid permease](/source/Amino_acid_permease)
A permease (porter) is a protein or protein complex that catalyzes a vectorial reaction, irrespective of whether or not it also catalyzes a chemical or electron transfer reaction that drives the vectorial process.

==References==
{{Reflist}}

==External links==
* {{MeshName|Permeases}}

Category:Transport proteins
Category:Transmembrane proteins

{{Enzyme-stub}}

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