# PRSS3

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/PRSS3
> Markdown URL: https://mediated.wiki/source/PRSS3.md
> Source: https://en.wikipedia.org/wiki/PRSS3
> Source revision: 1328170678
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Protease, serine, 3''' is a [protein](/source/protein) that in humans is encoded by the PRSS3 [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: Protease, serine, 3 | url = https://www.ncbi.nlm.nih.gov/gene/5646 }}</ref>

== Function ==

This gene encodes a [trypsinogen](/source/trypsinogen), which is a member of the [trypsin](/source/trypsin) family of [serine protease](/source/serine_protease)s. This enzyme is expressed in the [brain](/source/brain) and [pancreas](/source/pancreas) and is resistant to common [trypsin inhibitor](/source/trypsin_inhibitor)s. It is active on [peptide](/source/peptide) linkages involving the carboxyl group of [lysine](/source/lysine) or [arginine](/source/arginine). This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Koistinen H, Koistinen R, Zhang WM, Valmu L, Stenman UH | title = Nexin-1 inhibits the activity of human brain trypsin | journal = Neuroscience | volume = 160 | issue = 1 | pages = 97–102 | date = April 2009 | pmid = 19249338 | doi = 10.1016/j.neuroscience.2009.02.042 | s2cid = 23924027 }}
* {{cite journal | vauthors = Tani T, Kawashima I, Mita K, Takiguchi Y | title = Nucleotide sequence of the human pancreatic trypsinogen III cDNA | journal = Nucleic Acids Research | volume = 18 | issue = 6 | pages = 1631 | date = March 1990 | pmid = 2326201 | pmc = 330537 | doi = 10.1093/nar/18.6.1631 }}
* {{cite journal | vauthors = Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T | title = Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 46 | pages = 18766–71 | date = November 2011 | pmid = 22042864 | pmc = 3219097 | doi = 10.1073/pnas.1116273108 | bibcode = 2011PNAS..10818766H | doi-access = free }}
* {{cite journal | vauthors = Salameh MA, Robinson JL, Navaneetham D, Sinha D, Madden BJ, Walsh PN, Radisky ES | title = The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin | journal = The Journal of Biological Chemistry | volume = 285 | issue = 3 | pages = 1939–49 | date = January 2010 | pmid = 19920152 | pmc = 2804352 | doi = 10.1074/jbc.M109.057216 | doi-access = free }}
* {{cite journal | vauthors = Masson E, Le Maréchal C, Chen JM, Férec C | title = Absence of mesotrypsinogen gene (PRSS3) copy number variations in patients with chronic pancreatitis | journal = Pancreas | volume = 37 | issue = 2 | pages = 227���8 | date = August 2008 | pmid = 18665091 | doi = 10.1097/MPA.0b013e3181654b6a }}
* {{cite journal | vauthors = Nyaruhucha CN, Kito M, Fukuoka SI | title = Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance | journal = The Journal of Biological Chemistry | volume = 272 | issue = 16 | pages = 10573–8 | date = April 1997 | pmid = 9099703 | doi = 10.1074/jbc.272.16.10573 | doi-access = free }}
* {{cite journal | vauthors = Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW | title = Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia | journal = The Journal of Biological Chemistry | volume = 282 | issue = 36 | pages = 26089–100 | date = September 2007 | pmid = 17623652 | doi = 10.1074/jbc.M703840200 | doi-access = free }}
* {{cite journal | vauthors = Huntington JA, Read RJ, Carrell RW | title = Structure of a serpin-protease complex shows inhibition by deformation | journal = Nature | volume = 407 | issue = 6806 | pages = 923–6 | date = October 2000 | pmid = 11057674 | doi = 10.1038/35038119 | bibcode = 2000Natur.407..923H | s2cid = 205009937 }}
{{refend}}

{{NLM content}}

{{gene-9-stub}}

Category:Genes on human chromosome 9

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Adapted from the Wikipedia article [PRSS3](https://en.wikipedia.org/wiki/PRSS3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/PRSS3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.