# PREB

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Protein-coding gene in the species Homo sapiens

PREB Identifiers Aliases PREB, SEC12, prolactin regulatory element binding External IDs OMIM: 606395; MGI: 1355326; HomoloGene: 40877; GeneCards: PREB; OMA:PREB - orthologs Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,130,756 bp[1] End 27,134,666 bp[1] Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 30,950,853 bp[2] End 30,960,361 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gastrocnemius muscle left uterine tube muscle of thigh body of pancreas apex of heart body of uterus right ovary granulocyte mucosa of transverse colon Top expressed in fossa condyle Paneth cell granulocyte motor neuron seminal vesicula yolk sac internal carotid artery neural layer of retina endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA binding guanyl-nucleotide exchange factor activity protein binding GTPase activator activity GTPase binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum endoplasmic reticulum exit site Golgi membrane nucleus integral component of endoplasmic reticulum membrane Biological process protein transport IRE1-mediated unfolded protein response vesicle-mediated transport transcription, DNA-templated positive regulation of GTPase activity regulation of transcription, DNA-templated COPII vesicle coating protein exit from endoplasmic reticulum endoplasmic reticulum to Golgi vesicle-mediated transport regulation of COPII vesicle coating protein secretion transport regulation of molecular function regulation of catalytic activity Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 10113 50907 Ensembl ENSG00000138073 ENSMUSG00000045302 UniProt Q9HCU5 Q9WUQ2 RefSeq (mRNA) NM_001330484 NM_001330485 NM_001330486 NM_001330487 NM_013388 NM_001294302 NM_016703 RefSeq (protein) NP_001317413 NP_001317414 NP_001317415 NP_001317416 NP_037520 NP_001281231 NP_057912 Location (UCSC) Chr 2: 27.13 – 27.13 Mb Chr 5: 30.95 – 30.96 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Prolactin regulatory element-binding protein** is a [protein](/source/Protein) that in humans is encoded by the *PREB* [gene](/source/Gene).[5][6][7]

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000138073](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000138073) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000045302](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000045302) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=10113). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=50907). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid10194769_5-0)** Fliss MS, Hinkle PM, Bancroft C (May 1999). ["Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity"](https://doi.org/10.1210%2Fmend.13.4.0260). *Mol Endocrinol*. **13** (4): 644–657. [doi](/source/Doi_(identifier)):[10.1210/mend.13.4.0260](https://doi.org/10.1210%2Fmend.13.4.0260). [PMID](/source/PMID_(identifier)) [10194769](https://pubmed.ncbi.nlm.nih.gov/10194769).

1. **[^](#cite_ref-pmid12735795_6-0)** Edgar AJ (Jul 2003). ["The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156608). *BMC Genomics*. **4** (1): 18. [doi](/source/Doi_(identifier)):[10.1186/1471-2164-4-18](https://doi.org/10.1186%2F1471-2164-4-18). [PMC](/source/PMC_(identifier)) [156608](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156608). [PMID](/source/PMID_(identifier)) [12735795](https://pubmed.ncbi.nlm.nih.gov/12735795).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: PREB prolactin regulatory element binding"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10113).

## Further reading

- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". *Science*. **307** (5715): 1621–1625. [Bibcode](/source/Bibcode_(identifier)):[2005Sci...307.1621B](https://ui.adsabs.harvard.edu/abs/2005Sci...307.1621B). [doi](/source/Doi_(identifier)):[10.1126/science.1105776](https://doi.org/10.1126%2Fscience.1105776). [PMID](/source/PMID_(identifier)) [15761153](https://pubmed.ncbi.nlm.nih.gov/15761153). [S2CID](/source/S2CID_(identifier)) [39457788](https://api.semanticscholar.org/CorpusID:39457788).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–2127. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–45. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–16903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Taylor Clelland CL, Levy B, McKie JM, et al. (2000). "Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome". *Mamm. Genome*. **11** (8): 675–681. [doi](/source/Doi_(identifier)):[10.1007/s003350010142](https://doi.org/10.1007%2Fs003350010142). [PMID](/source/PMID_(identifier)) [10920239](https://pubmed.ncbi.nlm.nih.gov/10920239). [S2CID](/source/S2CID_(identifier)) [22946856](https://api.semanticscholar.org/CorpusID:22946856).

## External links

- [*PREB*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=PREB) human gene location in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

- [*PREB*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=PREB) human gene details in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

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