# PPM1G

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> Source: https://en.wikipedia.org/wiki/PPM1G
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Protein phosphatase 1G''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''PPM1G'' [gene](/source/gene).<ref name="pmid9276438">{{cite journal |vauthors=Travis SM, Welsh MJ | title = PP2C gamma: a human protein phosphatase with a unique acidic domain | journal = FEBS Lett | volume = 412 | issue = 3 | pages = 415–9 |date=Sep 1997 | pmid = 9276438 | doi =10.1016/S0014-5793(97)00837-5  | s2cid = 82436336 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5496}}</ref>

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.<ref name="entrez" />

==References==
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==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Guthridge MA, Bellosta P, Tavoloni N, Basilico C |title=FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 5485–98 |year= 1997 |pmid= 9271424 |doi=  10.1128/mcb.17.9.5485| pmc=232397  }}
*{{cite journal  |vauthors=Murray MV, Kobayashi R, Krainer AR |title=The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor |journal=Genes Dev. |volume=13 |issue= 1 |pages= 87–97 |year= 1999 |pmid= 9887102 |doi=10.1101/gad.13.1.87  | pmc=316367  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | author=Flajolet M |title=Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 16006–11 |year= 2004 |pmid= 14663150 |doi= 10.1073/pnas.2136600100  | pmc=307683  |name-list-style=vanc| author2=Rakhilin S  | author3=Wang H  | display-authors=3  | last4=Starkova  | first4=N  | last5=Nuangchamnong  | first5=N  | last6=Nairn  | first6=AC  | last7=Greengard  | first7=P |doi-access=free }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Maynes JT |title=Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins |journal=J. Mol. Biol. |volume=356 |issue= 1 |pages= 111–20 |year= 2006 |pmid= 16343532 |doi= 10.1016/j.jmb.2005.11.019  |name-list-style=vanc| author2=Luu HA  | author3=Cherney MM  | display-authors=3  | last4=Andersen  | first4=Raymond J.  | last5=Williams  | first5=David  | last6=Holmes  | first6=Charles F.B.  | last7=James  | first7=Michael N.G. }}
*{{cite journal  |vauthors=Suh EJ, Kim TY, Kim SH |title=PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1) |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6100–4 |year= 2007 |pmid= 17054950 |doi= 10.1016/j.febslet.2006.10.005 |s2cid=81205783 }}
*{{cite journal  | author=Kimura H |title=A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B |journal=J. Cell Biol. |volume=175 |issue= 3 |pages= 389–400 |year= 2006 |pmid= 17074886 |doi= 10.1083/jcb.200608001  | pmc=2064517  |name-list-style=vanc| author2=Takizawa N  | author3=Allemand E  | display-authors=3  | last4=Hori  | first4=T.  | last5=Iborra  | first5=F. J.  | last6=Nozaki  | first6=N.  | last7=Muraki  | first7=M.  | last8=Hagiwara  | first8=M.  | last9=Krainer  | first9=A. R. }}
*{{cite journal  | author=Luo W |title=Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex |journal=EMBO J. |volume=26 |issue= 6 |pages= 1511–21 |year= 2007 |pmid= 17318175 |doi= 10.1038/sj.emboj.7601607  | pmc=1829374  |name-list-style=vanc| author2=Peterson A  | author3=Garcia BA  | display-authors=3  | last4=Coombs  | first4=Gary  | last5=Kofahl  | first5=Bente  | last6=Heinrich  | first6=Reinhart  | last7=Shabanowitz  | first7=Jeffrey  | last8=Hunt  | first8=Donald F  | last9=Yost  | first9=H Joseph }}
*{{cite journal  | author=Allemand E |title=Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1 |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 7 |pages= 630–8 |year= 2007 |pmid= 17572683 |doi= 10.1038/nsmb1257  |name-list-style=vanc| author2=Hastings ML  | author3=Murray MV  | display-authors=3  | last4=Myers  | first4=Michael P  | last5=Krainer  | first5=Adrian R |s2cid=3187530 }}
*{{cite journal  | author=Petri S |title=Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex |journal=J. Cell Biol. |volume=179 |issue= 3 |pages= 451–65 |year= 2007 |pmid= 17984321 |doi= 10.1083/jcb.200704163  | pmc=2064792  |name-list-style=vanc| author2=Grimmler M  | author3=Over S  | display-authors=3  | last4=Fischer  | first4=U.  | last5=Gruss  | first5=O. J. }}
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Adapted from the Wikipedia article [PPM1G](https://en.wikipedia.org/wiki/PPM1G) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/PPM1G?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.