# PPIP5K2

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**Diphosphoinositol pentakisphosphate kinase 2** is a [protein](/source/Protein) that in humans is encoded by the PPIP5K2 [gene](/source/Gene). [1]

## Function

[Inositol phosphates](/source/Inositol_phosphate) (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as [cell signaling](/source/Cell_signaling) molecules.

HISPPD1 has both [IP6](/source/IP6) kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy [pyrophosphates](/source/Pyrophosphate) PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

## References

1. ["Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2"](https://www.ncbi.nlm.nih.gov/gene/23262). Retrieved 2017-03-21.

## Further reading

- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". *Mol. Med.*. **16** (7–8): 247–53. [doi:10.2119/molmed.2009.00159](https://doi.org/10.2119/molmed.2009.00159). [PMC 2896464](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896464). [PMID 20379614](https://pubmed.ncbi.nlm.nih.gov/20379614)
- Wang H, Falck JR, Hall TM, Shears SB (2011). "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding". *Nat. Chem. Biol.*. **8** (1): 111–6. [doi:10.1038/nchembio.733](https://doi.org/10.1038/nchembio.733). [PMC 3923263](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923263). [PMID 22119861](https://pubmed.ncbi.nlm.nih.gov/22119861)
- Weaver JD, Wang H, Shears SB (2013). "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment". *Biosci. Rep.*. **33** (2): e00022. [doi:10.1042/BSR20120115](https://doi.org/10.1042/BSR20120115). [PMC 3564036](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564036). [PMID 23240582](https://pubmed.ncbi.nlm.nih.gov/23240582)
- Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB (2015). "Identification of a functional nuclear translocation sequence in hPPIP5K2". *BMC Cell Biol.*. **16**: 17. [doi:10.1186/s12860-015-0063-7](https://doi.org/10.1186/s12860-015-0063-7). [PMC 4472268](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472268). [PMID 26084399](https://pubmed.ncbi.nlm.nih.gov/26084399)

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Adapted from the Wikipedia article [PPIP5K2](https://en.wikipedia.org/wiki/PPIP5K2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/PPIP5K2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.