# POLR2H

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/POLR2H
> Markdown URL: https://mediated.wiki/source/POLR2H.md
> Source: https://en.wikipedia.org/wiki/POLR2H
> Source revision: 1301023788
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Protein-coding gene in the species Homo sapiens

POLR2H Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F3I, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6 Identifiers Aliases POLR2H, RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H External IDs OMIM: 606023; MGI: 2384309; HomoloGene: 4540; GeneCards: POLR2H; OMA:POLR2H - orthologs Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,361,718 bp[1] End 184,368,596 bp[1] Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B1 Start 20,536,415 bp[2] End 20,541,017 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon pancreatic ductal cell right lobe of thyroid gland right uterine tube left lobe of thyroid gland right adrenal gland right adrenal cortex left adrenal cortex rectum canal of the cervix Top expressed in epiblast embryo morula embryo ventricular zone neural tube yolk sac tail of embryo ganglionic eminence ileum More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity single-stranded DNA binding Cellular component nucleolus RNA polymerase II, core complex nucleoplasm cytosol nucleus RNA polymerase III complex RNA polymerase I complex protein-DNA complex Biological process 7-methylguanosine mRNA capping transcription elongation from RNA polymerase II promoter transcription initiation from RNA polymerase I promoter mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription-coupled nucleotide-excision repair termination of RNA polymerase I transcription transcription initiation from RNA polymerase II promoter transcription by RNA polymerase II snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 5437 245841 Ensembl ENSG00000163882 ENSMUSG00000021018 UniProt P52434 Q923G2 RefSeq (mRNA) NM_001278698 NM_001278699 NM_001278700 NM_001278714 NM_001278715 NM_006232 NM_001346879 NM_145632 NM_001356423 RefSeq (protein) NP_001265627 NP_001265628 NP_001265629 NP_001265643 NP_001265644 NP_001333808 NP_006223 NP_663607 NP_001343352 Location (UCSC) Chr 3: 184.36 – 184.37 Mb Chr 16: 20.54 – 20.54 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**DNA-directed RNA polymerases I, II, and III subunit RPABC3** is a [protein](/source/Protein) that in humans is encoded by the *POLR2H* [gene](/source/Gene).

This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.[5]

## Interactions

POLR2H has been shown to [interact](/source/Protein-protein_interaction) with [POLR2C](/source/POLR2C),[6] [POLR2G](/source/POLR2G),[6] [POLR2A](/source/POLR2A),[6] [POLR2B](/source/POLR2B)[6] and [POLR2E](/source/POLR2E).[6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000163882](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000163882) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000021018](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000021018) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=5437). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=245841). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-5)** ["Entrez Gene: POLR2H polymerase (RNA) II (DNA directed) polypeptide H"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5437).

1. ^ [***a***](#cite_ref-pmid9201987_6-0) [***b***](#cite_ref-pmid9201987_6-1) [***c***](#cite_ref-pmid9201987_6-2) [***d***](#cite_ref-pmid9201987_6-3) [***e***](#cite_ref-pmid9201987_6-4) Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). ["Interactions between the human RNA polymerase II subunits"](https://doi.org/10.1074%2Fjbc.272.27.16815). *J. Biol. Chem*. **272** (27). UNITED STATES: 16815–21. [doi](/source/Doi_(identifier)):[10.1074/jbc.272.27.16815](https://doi.org/10.1074%2Fjbc.272.27.16815). [ISSN](/source/ISSN_(identifier)) [0021-9258](https://search.worldcat.org/issn/0021-9258). [PMID](/source/PMID_(identifier)) [9201987](https://pubmed.ncbi.nlm.nih.gov/9201987).

## Further reading

- Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". *J. Biomed. Sci*. **5** (1): 24–7. [doi](/source/Doi_(identifier)):[10.1007/BF02253352](https://doi.org/10.1007%2FBF02253352). [PMID](/source/PMID_(identifier)) [9570510](https://pubmed.ncbi.nlm.nih.gov/9570510).

- Yankulov K, Bentley D (1998). ["Transcriptional control: Tat cofactors and transcriptional elongation"](https://doi.org/10.1016%2FS0960-9822%2898%2970289-1). *Curr. Biol*. **8** (13): R447–9. [Bibcode](/source/Bibcode_(identifier)):[1998CBio....8.R447Y](https://ui.adsabs.harvard.edu/abs/1998CBio....8.R447Y). [doi](/source/Doi_(identifier)):[10.1016/S0960-9822(98)70289-1](https://doi.org/10.1016%2FS0960-9822%2898%2970289-1). [PMID](/source/PMID_(identifier)) [9651670](https://pubmed.ncbi.nlm.nih.gov/9651670). [S2CID](/source/S2CID_(identifier)) [15480646](https://api.semanticscholar.org/CorpusID:15480646).

- Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". *J. Cell. Biochem*. **75** (3): 357–68. [doi](/source/Doi_(identifier)):[10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K](https://doi.org/10.1002%2F%28SICI%291097-4644%2819991201%2975%3A3%3C357%3A%3AAID-JCB1%3E3.0.CO%3B2-K). [PMID](/source/PMID_(identifier)) [10536359](https://pubmed.ncbi.nlm.nih.gov/10536359). [S2CID](/source/S2CID_(identifier)) [43685090](https://api.semanticscholar.org/CorpusID:43685090).

- Marcello A, Zoppé M, Giacca M (2002). ["Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator"](https://doi.org/10.1080%2F152165401753544241). *IUBMB Life*. **51** (3): 175–81. [doi](/source/Doi_(identifier)):[10.1080/152165401753544241](https://doi.org/10.1080%2F152165401753544241). [PMID](/source/PMID_(identifier)) [11547919](https://pubmed.ncbi.nlm.nih.gov/11547919). [S2CID](/source/S2CID_(identifier)) [10931640](https://api.semanticscholar.org/CorpusID:10931640).

- Stevens M, De Clercq E, Balzarini J (2007). ["The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168390). *Med Res Rev*. **26** (5): 595–625. [doi](/source/Doi_(identifier)):[10.1002/med.20081](https://doi.org/10.1002%2Fmed.20081). [PMC](/source/PMC_(identifier)) [7168390](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168390). [PMID](/source/PMID_(identifier)) [16838299](https://pubmed.ncbi.nlm.nih.gov/16838299).

- Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". *Current Drug Targets*. **7** (12): 1595–606. [doi](/source/Doi_(identifier)):[10.2174/138945006779025338](https://doi.org/10.2174%2F138945006779025338). [PMID](/source/PMID_(identifier)) [17168834](https://pubmed.ncbi.nlm.nih.gov/17168834).

- Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". *J. Acquir. Immune Defic. Syndr*. **5** (11): 1142–7. [PMID](/source/PMID_(identifier)) [1403646](https://pubmed.ncbi.nlm.nih.gov/1403646).

- Kato H, Sumimoto H, Pognonec P, et al. (1992). ["HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors"](https://doi.org/10.1101%2Fgad.6.4.655). *Genes Dev*. **6** (4): 655–66. [doi](/source/Doi_(identifier)):[10.1101/gad.6.4.655](https://doi.org/10.1101%2Fgad.6.4.655). [PMID](/source/PMID_(identifier)) [1559613](https://pubmed.ncbi.nlm.nih.gov/1559613).

- Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". *Nature*. **345** (6276): 640–2. [Bibcode](/source/Bibcode_(identifier)):[1990Natur.345..640S](https://ui.adsabs.harvard.edu/abs/1990Natur.345..640S). [doi](/source/Doi_(identifier)):[10.1038/345640a0](https://doi.org/10.1038%2F345640a0). [PMID](/source/PMID_(identifier)) [2190099](https://pubmed.ncbi.nlm.nih.gov/2190099). [S2CID](/source/S2CID_(identifier)) [4233742](https://api.semanticscholar.org/CorpusID:4233742).

- Freund E, McGuire PM (1986). "Characterization of RNA polymerase type II from human term placenta". *J. Cell. Physiol*. **127** (3): 432–8. [doi](/source/Doi_(identifier)):[10.1002/jcp.1041270312](https://doi.org/10.1002%2Fjcp.1041270312). [PMID](/source/PMID_(identifier)) [3754875](https://pubmed.ncbi.nlm.nih.gov/3754875). [S2CID](/source/S2CID_(identifier)) [11708971](https://api.semanticscholar.org/CorpusID:11708971).

- Wu-Baer F, Sigman D, [Gaynor RB](/source/Richard_Gaynor) (1995). ["Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41297). *Proc. Natl. Acad. Sci. U.S.A*. **92** (16): 7153–7. [Bibcode](/source/Bibcode_(identifier)):[1995PNAS...92.7153W](https://ui.adsabs.harvard.edu/abs/1995PNAS...92.7153W). [doi](/source/Doi_(identifier)):[10.1073/pnas.92.16.7153](https://doi.org/10.1073%2Fpnas.92.16.7153). [PMC](/source/PMC_(identifier)) [41297](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41297). [PMID](/source/PMID_(identifier)) [7638159](https://pubmed.ncbi.nlm.nih.gov/7638159).

- Shpakovski GV, Acker J, Wintzerith M, et al. (1995). ["Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230713). *Mol. Cell. Biol*. **15** (9): 4702–10. [doi](/source/Doi_(identifier)):[10.1128/mcb.15.9.4702](https://doi.org/10.1128%2Fmcb.15.9.4702). [PMC](/source/PMC_(identifier)) [230713](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230713). [PMID](/source/PMID_(identifier)) [7651387](https://pubmed.ncbi.nlm.nih.gov/7651387).

- Herrmann CH, Rice AP (1995). ["Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188757). *J. Virol*. **69** (3): 1612–20. [doi](/source/Doi_(identifier)):[10.1128/JVI.69.3.1612-1620.1995](https://doi.org/10.1128%2FJVI.69.3.1612-1620.1995). [PMC](/source/PMC_(identifier)) [188757](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188757). [PMID](/source/PMID_(identifier)) [7853496](https://pubmed.ncbi.nlm.nih.gov/7853496).

- McKune K, Moore PA, Hull MW, Woychik NA (1996). ["Six human RNA polymerase subunits functionally substitute for their yeast counterparts"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230944). *Mol. Cell. Biol*. **15** (12): 6895–900. [doi](/source/Doi_(identifier)):[10.1128/mcb.15.12.6895](https://doi.org/10.1128%2Fmcb.15.12.6895). [PMC](/source/PMC_(identifier)) [230944](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230944). [PMID](/source/PMID_(identifier)) [8524256](https://pubmed.ncbi.nlm.nih.gov/8524256).

- Keen NJ, Gait MJ, Karn J (1996). ["Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39827). *Proc. Natl. Acad. Sci. U.S.A*. **93** (6): 2505–10. [Bibcode](/source/Bibcode_(identifier)):[1996PNAS...93.2505K](https://ui.adsabs.harvard.edu/abs/1996PNAS...93.2505K). [doi](/source/Doi_(identifier)):[10.1073/pnas.93.6.2505](https://doi.org/10.1073%2Fpnas.93.6.2505). [PMC](/source/PMC_(identifier)) [39827](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39827). [PMID](/source/PMID_(identifier)) [8637904](https://pubmed.ncbi.nlm.nih.gov/8637904).

- Yang X, Herrmann CH, Rice AP (1996). ["The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC190394). *J. Virol*. **70** (7): 4576–84. [doi](/source/Doi_(identifier)):[10.1128/JVI.70.7.4576-4584.1996](https://doi.org/10.1128%2FJVI.70.7.4576-4584.1996). [PMC](/source/PMC_(identifier)) [190394](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC190394). [PMID](/source/PMID_(identifier)) [8676484](https://pubmed.ncbi.nlm.nih.gov/8676484).

- Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". *J. Mol. Biol*. **261** (5): 599–606. [doi](/source/Doi_(identifier)):[10.1006/jmbi.1996.0485](https://doi.org/10.1006%2Fjmbi.1996.0485). [PMID](/source/PMID_(identifier)) [8800208](https://pubmed.ncbi.nlm.nih.gov/8800208).

- Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". *Science*. **274** (5287): 605–10. [Bibcode](/source/Bibcode_(identifier)):[1996Sci...274..605Z](https://ui.adsabs.harvard.edu/abs/1996Sci...274..605Z). [doi](/source/Doi_(identifier)):[10.1126/science.274.5287.605](https://doi.org/10.1126%2Fscience.274.5287.605). [PMID](/source/PMID_(identifier)) [8849451](https://pubmed.ncbi.nlm.nih.gov/8849451). [S2CID](/source/S2CID_(identifier)) [13266489](https://api.semanticscholar.org/CorpusID:13266489).

- Okamoto H, Sheline CT, Corden JL, et al. (1996). ["Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38099). *Proc. Natl. Acad. Sci. U.S.A*. **93** (21): 11575–9. [Bibcode](/source/Bibcode_(identifier)):[1996PNAS...9311575O](https://ui.adsabs.harvard.edu/abs/1996PNAS...9311575O). [doi](/source/Doi_(identifier)):[10.1073/pnas.93.21.11575](https://doi.org/10.1073%2Fpnas.93.21.11575). [PMC](/source/PMC_(identifier)) [38099](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38099). [PMID](/source/PMID_(identifier)) [8876177](https://pubmed.ncbi.nlm.nih.gov/8876177).

- Chun RF, Jeang KT (1996). ["Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1"](https://doi.org/10.1074%2Fjbc.271.44.27888). *J. Biol. Chem*. **271** (44): 27888–94. [doi](/source/Doi_(identifier)):[10.1074/jbc.271.44.27888](https://doi.org/10.1074%2Fjbc.271.44.27888). [PMID](/source/PMID_(identifier)) [8910388](https://pubmed.ncbi.nlm.nih.gov/8910388).

v t e PDB gallery 2f3i: Solution Structure of a Subunit of RNA Polymerase II

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Gene-3-stub)
- [t](/source/Template_talk%3AGene-3-stub)
- [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:Gene-3-stub)

---
Adapted from the Wikipedia article [POLR2H](https://en.wikipedia.org/wiki/POLR2H) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/POLR2H?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.