# POLR2G

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Protein-coding gene in the species Homo sapiens

POLR2G Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C35, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6 Identifiers Aliases POLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G External IDs OMIM: 602013; MGI: 1914960; HomoloGene: 2019; GeneCards: POLR2G; OMA:POLR2G - orthologs Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,761,565 bp[1] End 62,766,710 bp[1] Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,770,491 bp[2] End 8,775,941 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone granulocyte ganglionic eminence C1 segment right adrenal gland right adrenal cortex monocyte stromal cell of endometrium Descending thoracic aorta rectum Top expressed in medial ganglionic eminence endocardial cushion primary oocyte facial motor nucleus otic placode atrioventricular junction condyle primitive streak renal corpuscle mandibular prominence More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity single-stranded DNA binding single-stranded RNA binding RNA binding nucleic acid binding translation initiation factor binding Cellular component P-body nucleoplasm RNA polymerase II, core complex nucleus Biological process mRNA splicing, via spliceosome positive regulation of nuclear-transcribed mRNA poly(A) tail shortening transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter positive regulation of translational initiation nuclear-transcribed mRNA catabolic process, exonucleolytic apoptotic process snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 5436 67710 Ensembl ENSG00000168002 ENSMUSG00000071662 UniProt P62487 P62488 RefSeq (mRNA) NM_002696 NM_026329 RefSeq (protein) NP_002687 NP_080605 Location (UCSC) Chr 11: 62.76 – 62.77 Mb Chr 19: 8.77 – 8.78 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**DNA-directed RNA polymerase II subunit RPB7** is an [enzyme](/source/Enzyme) that in humans is encoded by the *POLR2G* [gene](/source/Gene).[5][6]

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.[7]

## Interactions

POLR2G has been shown to [interact](/source/Protein-protein_interaction) with [TAF15](/source/TAF15),[8] [POLR2C](/source/POLR2C),[9] [POLR2H](/source/POLR2H)[9] and [POLR2E](/source/POLR2E).[9]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000168002](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000168002) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000071662](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000071662) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=5436). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=67710). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid7579693_5-0)** Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). ["Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC301239). *Mol Biol Cell*. **6** (7): 759–75. [doi](/source/Doi_(identifier)):[10.1091/mbc.6.7.759](https://doi.org/10.1091%2Fmbc.6.7.759). [PMC](/source/PMC_(identifier)) [301239](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC301239). [PMID](/source/PMID_(identifier)) [7579693](https://pubmed.ncbi.nlm.nih.gov/7579693).

1. **[^](#cite_ref-pmid9256063_6-0)** Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). ["Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization"](https://zenodo.org/record/1259891). *Biochim Biophys Acta*. **1353** (1): 39–49. [doi](/source/Doi_(identifier)):[10.1016/s0167-4781(97)00041-9](https://doi.org/10.1016%2Fs0167-4781%2897%2900041-9). [PMID](/source/PMID_(identifier)) [9256063](https://pubmed.ncbi.nlm.nih.gov/9256063).

1. **[^](#cite_ref-7)** ["Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5436).

1. **[^](#cite_ref-pmid9488465_8-0)** Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (March 1998). ["EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108863). *Mol. Cell. Biol*. **18** (3). UNITED STATES: 1489–97. [doi](/source/Doi_(identifier)):[10.1128/mcb.18.3.1489](https://doi.org/10.1128%2Fmcb.18.3.1489). [ISSN](/source/ISSN_(identifier)) [0270-7306](https://search.worldcat.org/issn/0270-7306). [PMC](/source/PMC_(identifier)) [108863](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108863). [PMID](/source/PMID_(identifier)) [9488465](https://pubmed.ncbi.nlm.nih.gov/9488465).

1. ^ [***a***](#cite_ref-pmid9201987_9-0) [***b***](#cite_ref-pmid9201987_9-1) [***c***](#cite_ref-pmid9201987_9-2) Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). ["Interactions between the human RNA polymerase II subunits"](https://doi.org/10.1074%2Fjbc.272.27.16815). *J. Biol. Chem*. **272** (27). UNITED STATES: 16815–21. [doi](/source/Doi_(identifier)):[10.1074/jbc.272.27.16815](https://doi.org/10.1074%2Fjbc.272.27.16815). [ISSN](/source/ISSN_(identifier)) [0021-9258](https://search.worldcat.org/issn/0021-9258). [PMID](/source/PMID_(identifier)) [9201987](https://pubmed.ncbi.nlm.nih.gov/9201987).

## Further reading

- Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". *J. Biomed. Sci*. **5** (1): 24–7. [doi](/source/Doi_(identifier)):[10.1007/BF02253352](https://doi.org/10.1007%2FBF02253352). [PMID](/source/PMID_(identifier)) [9570510](https://pubmed.ncbi.nlm.nih.gov/9570510).

- Yankulov K, Bentley D (1998). ["Transcriptional control: Tat cofactors and transcriptional elongation"](https://doi.org/10.1016%2FS0960-9822%2898%2970289-1). *Curr. Biol*. **8** (13): R447–9. [Bibcode](/source/Bibcode_(identifier)):[1998CBio....8.R447Y](https://ui.adsabs.harvard.edu/abs/1998CBio....8.R447Y). [doi](/source/Doi_(identifier)):[10.1016/S0960-9822(98)70289-1](https://doi.org/10.1016%2FS0960-9822%2898%2970289-1). [PMID](/source/PMID_(identifier)) [9651670](https://pubmed.ncbi.nlm.nih.gov/9651670). [S2CID](/source/S2CID_(identifier)) [15480646](https://api.semanticscholar.org/CorpusID:15480646).

- Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". *J. Cell. Biochem*. **75** (3): 357–68. [doi](/source/Doi_(identifier)):[10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K](https://doi.org/10.1002%2F%28SICI%291097-4644%2819991201%2975%3A3%3C357%3A%3AAID-JCB1%3E3.0.CO%3B2-K). [PMID](/source/PMID_(identifier)) [10536359](https://pubmed.ncbi.nlm.nih.gov/10536359). [S2CID](/source/S2CID_(identifier)) [43685090](https://api.semanticscholar.org/CorpusID:43685090).

- Marcello A, Zoppé M, Giacca M (2002). ["Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator"](https://doi.org/10.1080%2F152165401753544241). *IUBMB Life*. **51** (3): 175–81. [doi](/source/Doi_(identifier)):[10.1080/152165401753544241](https://doi.org/10.1080%2F152165401753544241). [PMID](/source/PMID_(identifier)) [11547919](https://pubmed.ncbi.nlm.nih.gov/11547919). [S2CID](/source/S2CID_(identifier)) [10931640](https://api.semanticscholar.org/CorpusID:10931640).

- Stevens M, De Clercq E, Balzarini J (2007). ["The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168390). *Med Res Rev*. **26** (5): 595–625. [doi](/source/Doi_(identifier)):[10.1002/med.20081](https://doi.org/10.1002%2Fmed.20081). [PMC](/source/PMC_(identifier)) [7168390](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168390). [PMID](/source/PMID_(identifier)) [16838299](https://pubmed.ncbi.nlm.nih.gov/16838299).

- Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". *Current Drug Targets*. **7** (12): 1595–606. [doi](/source/Doi_(identifier)):[10.2174/138945006779025338](https://doi.org/10.2174%2F138945006779025338). [PMID](/source/PMID_(identifier)) [17168834](https://pubmed.ncbi.nlm.nih.gov/17168834).

- Kato H, Sumimoto H, Pognonec P, et al. (1992). ["HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors"](https://doi.org/10.1101%2Fgad.6.4.655). *Genes Dev*. **6** (4): 655–66. [doi](/source/Doi_(identifier)):[10.1101/gad.6.4.655](https://doi.org/10.1101%2Fgad.6.4.655). [PMID](/source/PMID_(identifier)) [1559613](https://pubmed.ncbi.nlm.nih.gov/1559613).

- Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". *Nature*. **345** (6276): 640–2. [Bibcode](/source/Bibcode_(identifier)):[1990Natur.345..640S](https://ui.adsabs.harvard.edu/abs/1990Natur.345..640S). [doi](/source/Doi_(identifier)):[10.1038/345640a0](https://doi.org/10.1038%2F345640a0). [PMID](/source/PMID_(identifier)) [2190099](https://pubmed.ncbi.nlm.nih.gov/2190099). [S2CID](/source/S2CID_(identifier)) [4233742](https://api.semanticscholar.org/CorpusID:4233742).

- Wu-Baer F, Sigman D, [Gaynor RB](/source/Richard_Gaynor) (1995). ["Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41297). *Proc. Natl. Acad. Sci. U.S.A*. **92** (16): 7153–7. [Bibcode](/source/Bibcode_(identifier)):[1995PNAS...92.7153W](https://ui.adsabs.harvard.edu/abs/1995PNAS...92.7153W). [doi](/source/Doi_(identifier)):[10.1073/pnas.92.16.7153](https://doi.org/10.1073%2Fpnas.92.16.7153). [PMC](/source/PMC_(identifier)) [41297](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41297). [PMID](/source/PMID_(identifier)) [7638159](https://pubmed.ncbi.nlm.nih.gov/7638159).

- Herrmann CH, Rice AP (1995). ["Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188757). *J. Virol*. **69** (3): 1612–20. [doi](/source/Doi_(identifier)):[10.1128/JVI.69.3.1612-1620.1995](https://doi.org/10.1128%2FJVI.69.3.1612-1620.1995). [PMC](/source/PMC_(identifier)) [188757](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188757). [PMID](/source/PMID_(identifier)) [7853496](https://pubmed.ncbi.nlm.nih.gov/7853496).

- Keen NJ, Gait MJ, Karn J (1996). ["Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39827). *Proc. Natl. Acad. Sci. U.S.A*. **93** (6): 2505–10. [Bibcode](/source/Bibcode_(identifier)):[1996PNAS...93.2505K](https://ui.adsabs.harvard.edu/abs/1996PNAS...93.2505K). [doi](/source/Doi_(identifier)):[10.1073/pnas.93.6.2505](https://doi.org/10.1073%2Fpnas.93.6.2505). [PMC](/source/PMC_(identifier)) [39827](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39827). [PMID](/source/PMID_(identifier)) [8637904](https://pubmed.ncbi.nlm.nih.gov/8637904).

- Yang X, Herrmann CH, Rice AP (1996). ["The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC190394). *J. Virol*. **70** (7): 4576–84. [doi](/source/Doi_(identifier)):[10.1128/JVI.70.7.4576-4584.1996](https://doi.org/10.1128%2FJVI.70.7.4576-4584.1996). [PMC](/source/PMC_(identifier)) [190394](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC190394). [PMID](/source/PMID_(identifier)) [8676484](https://pubmed.ncbi.nlm.nih.gov/8676484).

- Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". *J. Mol. Biol*. **261** (5): 599–606. [doi](/source/Doi_(identifier)):[10.1006/jmbi.1996.0485](https://doi.org/10.1006%2Fjmbi.1996.0485). [PMID](/source/PMID_(identifier)) [8800208](https://pubmed.ncbi.nlm.nih.gov/8800208).

- Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". *Science*. **274** (5287): 605–10. [Bibcode](/source/Bibcode_(identifier)):[1996Sci...274..605Z](https://ui.adsabs.harvard.edu/abs/1996Sci...274..605Z). [doi](/source/Doi_(identifier)):[10.1126/science.274.5287.605](https://doi.org/10.1126%2Fscience.274.5287.605). [PMID](/source/PMID_(identifier)) [8849451](https://pubmed.ncbi.nlm.nih.gov/8849451). [S2CID](/source/S2CID_(identifier)) [13266489](https://api.semanticscholar.org/CorpusID:13266489).

- Okamoto H, Sheline CT, Corden JL, et al. (1996). ["Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38099). *Proc. Natl. Acad. Sci. U.S.A*. **93** (21): 11575–9. [Bibcode](/source/Bibcode_(identifier)):[1996PNAS...9311575O](https://ui.adsabs.harvard.edu/abs/1996PNAS...9311575O). [doi](/source/Doi_(identifier)):[10.1073/pnas.93.21.11575](https://doi.org/10.1073%2Fpnas.93.21.11575). [PMC](/source/PMC_(identifier)) [38099](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38099). [PMID](/source/PMID_(identifier)) [8876177](https://pubmed.ncbi.nlm.nih.gov/8876177).

- Chun RF, Jeang KT (1996). ["Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1"](https://doi.org/10.1074%2Fjbc.271.44.27888). *J. Biol. Chem*. **271** (44): 27888–94. [doi](/source/Doi_(identifier)):[10.1074/jbc.271.44.27888](https://doi.org/10.1074%2Fjbc.271.44.27888). [PMID](/source/PMID_(identifier)) [8910388](https://pubmed.ncbi.nlm.nih.gov/8910388).

- Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". *Nature*. **384** (6607): 375–8. [Bibcode](/source/Bibcode_(identifier)):[1996Natur.384..375P](https://ui.adsabs.harvard.edu/abs/1996Natur.384..375P). [doi](/source/Doi_(identifier)):[10.1038/384375a0](https://doi.org/10.1038%2F384375a0). [PMID](/source/PMID_(identifier)) [8934526](https://pubmed.ncbi.nlm.nih.gov/8934526). [S2CID](/source/S2CID_(identifier)) [4278432](https://api.semanticscholar.org/CorpusID:4278432).

- García-Martínez LF, Ivanov D, Gaynor RB (1997). ["Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes"](https://doi.org/10.1074%2Fjbc.272.11.6951). *J. Biol. Chem*. **272** (11): 6951–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.272.11.6951](https://doi.org/10.1074%2Fjbc.272.11.6951). [PMID](/source/PMID_(identifier)) [9054383](https://pubmed.ncbi.nlm.nih.gov/9054383).

- Cujec TP, Cho H, Maldonado E, et al. (1997). ["The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232028). *Mol. Cell. Biol*. **17** (4): 1817–23. [doi](/source/Doi_(identifier)):[10.1128/MCB.17.4.1817](https://doi.org/10.1128%2FMCB.17.4.1817). [PMC](/source/PMC_(identifier)) [232028](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232028). [PMID](/source/PMID_(identifier)) [9121429](https://pubmed.ncbi.nlm.nih.gov/9121429).

v t e PDB gallery 2c35: SUBUNITS RPB4 AND RPB7 OF HUMAN RNA POLYMERASE II

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Adapted from the Wikipedia article [POLR2G](https://en.wikipedia.org/wiki/POLR2G) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/POLR2G?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.