# PKD domain

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**PKD (Polycystic Kidney Disease)** domain was first identified in the [polycystic kidney disease](/source/Polycystic_kidney_disease) protein, polycystin-1 ([PKD1](/source/Polycystin_1) gene), and contains an [Ig-like fold](/source/Ig-like_fold) consisting of a [beta-sandwich](/source/Beta-sandwich) of seven strands in two sheets with a [Greek key topology](/source/Greek_key_(protein_structure)), although some members have additional strands.[1] Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein–protein and protein–carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions.

PKD domains are also found in other proteins, usually in the extracellular parts of proteins involved in interactions with other proteins. For example, domains with a PKD-type fold are found in archaeal [S-layer](/source/S-layer) proteins that protect the cell from extreme environments,[2] and in the human receptor [SorCS2](/source/SorCS2).[3]

## Human proteins containing this domain

[GPNMB](/source/GPNMB); [PKD1](/source/PKD1); [PKD1L1](/source/PKD1L1); [PMEL](/source/PMEL_(gene)); [SORCS1](/source/SORCS1); [SORCS2](/source/SORCS2); [SORCS3](/source/SORCS3)

## References

1. Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C (1999). "The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease". *EMBO J.*. **18** (2): 297–305. [doi:10.1093/emboj/18.2.297](https://doi.org/10.1093/emboj/18.2.297). [PMC 1171124](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171124). [PMID 9889186](https://pubmed.ncbi.nlm.nih.gov/9889186)

1. Joachimiak A, Springer TA, Zhang RG, Wang JH, Liu JH, Jing H, Takagi J, Lindgren S (2002). "Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins". *Structure*. **10** (10): 1453–1464. [doi:10.1016/S0969-2126(02)00840-7](https://doi.org/10.1016/S0969-2126(02)00840-7). [PMID 12377130](https://pubmed.ncbi.nlm.nih.gov/12377130)

1. Hermans-Borgmeyer I, Hampe W, Schaller HC, Rezgaoui M (2001). "The genes for the human VPS10 domain-containing receptors are large and contain many small exons". *Hum. Genet.*. **108** (6): 529–36. [doi:10.1007/s004390100504](https://doi.org/10.1007/s004390100504). [PMID 11499680](https://pubmed.ncbi.nlm.nih.gov/11499680). [S2CID 23375354](https://api.semanticscholar.org/CorpusID:23375354)

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Adapted from the Wikipedia article [PKD domain](https://en.wikipedia.org/wiki/PKD_domain) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/PKD_domain?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.