# PES1

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Protein-coding gene in the species Homo sapiens

PES1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EP8 Identifiers Aliases PES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7 External IDs OMIM: 605819; MGI: 1890613; HomoloGene: 5984; GeneCards: PES1; OMA:PES1 - orthologs Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,576,625 bp[1] End 30,607,083 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,913,975 bp[2] End 3,930,004 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve body of pancreas islet of Langerhans skin of leg mucosa of transverse colon skin of abdomen left testis stromal cell of endometrium body of stomach right testis Top expressed in interventricular septum yolk sac spermatocyte ventricular zone neural layer of retina tail of embryo spermatid otic vesicle embryo epiblast More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein binding RNA binding ribonucleoprotein complex binding Cellular component membrane PeBoW complex chromosome nucleolus condensed chromosome nucleus nucleoplasm cytosol preribosome, large subunit precursor Biological process protein localization to organelle ribosome biogenesis regulation of cell cycle nucleolus organization maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell population proliferation rRNA processing maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal large subunit biogenesis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 23481 64934 Ensembl ENSG00000100029 ENSMUSG00000020430 UniProt O00541 Q9EQ61 RefSeq (mRNA) NM_001243225 NM_001282327 NM_001282328 NM_014303 NM_022889 RefSeq (protein) NP_001230154 NP_001269256 NP_001269257 NP_055118 NP_075027 Location (UCSC) Chr 22: 30.58 – 30.61 Mb Chr 11: 3.91 – 3.93 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Pescadillo homolog** is a [protein](/source/Protein) that in humans is encoded by the *PES1* [gene](/source/Gene).[5][6][7][8]

This gene encodes a protein that is abnormally elevated in [malignant tumors](/source/Malignant_tumors) of [astrocytic](/source/Astrocytic) origin. It is a strongly conserved gene containing a [BRCT](/source/BRCT) domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for [oncogenic](/source/Oncogenic) transformation and tumor progression.[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000100029](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000100029) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000020430](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000020430) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=23481). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=64934). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8985183_5-0)** Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N (Jan 1997). ["Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development"](https://doi.org/10.1101%2Fgad.10.24.3141). *Genes Dev*. **10** (24): 3141–55. [doi](/source/Doi_(identifier)):[10.1101/gad.10.24.3141](https://doi.org/10.1101%2Fgad.10.24.3141). [PMID](/source/PMID_(identifier)) [8985183](https://pubmed.ncbi.nlm.nih.gov/8985183).

1. **[^](#cite_ref-pmid10591208_6-0)** Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). ["The DNA sequence of human chromosome 22"](https://doi.org/10.1038%2F990031). *Nature*. **402** (6761): 489–95. [Bibcode](/source/Bibcode_(identifier)):[1999Natur.402..489D](https://ui.adsabs.harvard.edu/abs/1999Natur.402..489D). [doi](/source/Doi_(identifier)):[10.1038/990031](https://doi.org/10.1038%2F990031). [PMID](/source/PMID_(identifier)) [10591208](https://pubmed.ncbi.nlm.nih.gov/10591208).

1. **[^](#cite_ref-pmid17353269_7-0)** Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). ["Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899993). *Mol Cell Biol*. **27** (10): 3682–94. [doi](/source/Doi_(identifier)):[10.1128/MCB.00172-07](https://doi.org/10.1128%2FMCB.00172-07). [PMC](/source/PMC_(identifier)) [1899993](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899993). [PMID](/source/PMID_(identifier)) [17353269](https://pubmed.ncbi.nlm.nih.gov/17353269).

1. ^ [***a***](#cite_ref-entrez_8-0) [***b***](#cite_ref-entrez_8-1) ["Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23481).

## Further reading

- Sanger Centre T, Washington University Genome Sequencing Cente T (1999). ["Toward a complete human genome sequence"](https://doi.org/10.1101%2Fgr.8.11.1097). *Genome Res*. **8** (11): 1097–108. [doi](/source/Doi_(identifier)):[10.1101/gr.8.11.1097](https://doi.org/10.1101%2Fgr.8.11.1097). [PMID](/source/PMID_(identifier)) [9847074](https://pubmed.ncbi.nlm.nih.gov/9847074).

- Kinoshita Y, Jarell AD, Flaman JM, et al. (2001). ["Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells"](https://doi.org/10.1074%2Fjbc.M008536200). *J. Biol. Chem*. **276** (9): 6656–65. [doi](/source/Doi_(identifier)):[10.1074/jbc.M008536200](https://doi.org/10.1074%2Fjbc.M008536200). [PMID](/source/PMID_(identifier)) [11071894](https://pubmed.ncbi.nlm.nih.gov/11071894).

- Andersen JS, Lyon CE, Fox AH, et al. (2002). ["Directed proteomic analysis of the human nucleolus"](https://doi.org/10.1016%2FS0960-9822%2801%2900650-9). *Curr. Biol*. **12** (1): 1–11. [Bibcode](/source/Bibcode_(identifier)):[2002CBio...12....1A](https://ui.adsabs.harvard.edu/abs/2002CBio...12....1A). [doi](/source/Doi_(identifier)):[10.1016/S0960-9822(01)00650-9](https://doi.org/10.1016%2FS0960-9822%2801%2900650-9). [PMID](/source/PMID_(identifier)) [11790298](https://pubmed.ncbi.nlm.nih.gov/11790298).

- Oeffinger M, Leung A, Lamond A, et al. (2002). ["Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370283). *RNA*. **8** (5): 626–36. [doi](/source/Doi_(identifier)):[10.1017/S1355838202020022](https://doi.org/10.1017%2FS1355838202020022). [PMC](/source/PMC_(identifier)) [1370283](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370283). [PMID](/source/PMID_(identifier)) [12022229](https://pubmed.ncbi.nlm.nih.gov/12022229).

- Scherl A, Couté Y, Déon C, et al. (2003). ["Functional Proteomic Analysis of Human Nucleolus"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133617). *Mol. Biol. Cell*. **13** (11): 4100–9. [doi](/source/Doi_(identifier)):[10.1091/mbc.E02-05-0271](https://doi.org/10.1091%2Fmbc.E02-05-0271). [PMC](/source/PMC_(identifier)) [133617](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133617). [PMID](/source/PMID_(identifier)) [12429849](https://pubmed.ncbi.nlm.nih.gov/12429849).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Lapik YR, Fernandes CJ, Lau LF, Pestov DG (2004). ["Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis"](https://doi.org/10.1016%2Fj.molcel.2004.05.020). *Mol. Cell*. **15** (1): 17–29. [doi](/source/Doi_(identifier)):[10.1016/j.molcel.2004.05.020](https://doi.org/10.1016%2Fj.molcel.2004.05.020). [PMID](/source/PMID_(identifier)) [15225545](https://pubmed.ncbi.nlm.nih.gov/15225545).

- Maiorana A, Tu X, Cheng G, Baserga R (2004). ["Role of pescadillo in the transformation and immortalization of mammalian cells"](https://doi.org/10.1038%2Fsj.onc.1207916). *Oncogene*. **23** (42): 7116–24. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1207916](https://doi.org/10.1038%2Fsj.onc.1207916). [PMID](/source/PMID_(identifier)) [15273728](https://pubmed.ncbi.nlm.nih.gov/15273728).

- Collins JE, Wright CL, Edwards CA, et al. (2005). ["A genome annotation-driven approach to cloning the human ORFeome"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545604). *Genome Biol*. **5** (10): R84. [doi](/source/Doi_(identifier)):[10.1186/gb-2004-5-10-r84](https://doi.org/10.1186%2Fgb-2004-5-10-r84). [PMC](/source/PMC_(identifier)) [545604](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545604). [PMID](/source/PMID_(identifier)) [15461802](https://pubmed.ncbi.nlm.nih.gov/15461802).

- Killian A, Le Meur N, Sesboüé R, et al. (2004). "Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability". *Oncogene*. **23** (53): 8597–602. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1207845](https://doi.org/10.1038%2Fsj.onc.1207845). [PMID](/source/PMID_(identifier)) [15467761](https://pubmed.ncbi.nlm.nih.gov/15467761). [S2CID](/source/S2CID_(identifier)) [7435460](https://api.semanticscholar.org/CorpusID:7435460).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". *Nature*. **433** (7021): 77–83. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.433...77A](https://ui.adsabs.harvard.edu/abs/2005Natur.433...77A). [doi](/source/Doi_(identifier)):[10.1038/nature03207](https://doi.org/10.1038%2Fnature03207). [PMID](/source/PMID_(identifier)) [15635413](https://pubmed.ncbi.nlm.nih.gov/15635413). [S2CID](/source/S2CID_(identifier)) [4344740](https://api.semanticscholar.org/CorpusID:4344740).

- Hölzel M, Rohrmoser M, Schlee M, et al. (2005). ["Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171466). *J. Cell Biol*. **170** (3): 367–78. [doi](/source/Doi_(identifier)):[10.1083/jcb.200501141](https://doi.org/10.1083%2Fjcb.200501141). [PMC](/source/PMC_(identifier)) [2171466](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171466). [PMID](/source/PMID_(identifier)) [16043514](https://pubmed.ncbi.nlm.nih.gov/16043514).

- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). ["Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). *Genome Res*. **16** (1): 55–65. [doi](/source/Doi_(identifier)):[10.1101/gr.4039406](https://doi.org/10.1101%2Fgr.4039406). [PMC](/source/PMC_(identifier)) [1356129](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). [PMID](/source/PMID_(identifier)) [16344560](https://pubmed.ncbi.nlm.nih.gov/16344560).

- Ewing RM, Chu P, Elisma F, et al. (2007). ["Large-scale mapping of human protein–protein interactions by mass spectrometry"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). *Mol. Syst. Biol*. **3** (1): 89. [doi](/source/Doi_(identifier)):[10.1038/msb4100134](https://doi.org/10.1038%2Fmsb4100134). [PMC](/source/PMC_(identifier)) [1847948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). [PMID](/source/PMID_(identifier)) [17353931](https://pubmed.ncbi.nlm.nih.gov/17353931).

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