# PECI (gene)

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Protein-coding gene in the species Homo sapiens

ECI2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQU, 2F6Q, 4U18, 4U19, 4U1A Identifiers Aliases ECI2, ACBD2, DRS-1, DRS1, HCA88, PECI, dJ1013A10.3, enoyl-CoA delta isomerase 2 External IDs OMIM: 608024; MGI: 1346064; HomoloGene: 38145; GeneCards: ECI2; OMA:ECI2 - orthologs Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.2 Start 4,115,693 bp[1] End 4,135,597 bp[1] Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.3 Start 35,161,731 bp[2] End 35,211,079 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex right ventricle triceps brachii muscle left adrenal gland biceps brachii Skeletal muscle tissue of biceps brachii glutes left adrenal cortex left ventricle Top expressed in saccule otic placode cardiac muscle tissue of left ventricle renal corpuscle otic vesicle interventricular septum proximal tubule hair follicle ventricular zone vestibular sensory epithelium More reference expression data BioGPS More reference expression data Gene ontology Molecular function intramolecular oxidoreductase activity, transposing C=C bonds signaling receptor binding catalytic activity isomerase activity fatty-acyl-CoA binding dodecenoyl-CoA delta-isomerase activity Cellular component membrane mitochondrion intracellular membrane-bounded organelle nucleoplasm peroxisomal matrix peroxisome cytosol Biological process fatty acid catabolic process fatty acid beta-oxidation metabolism fatty acid beta-oxidation using acyl-CoA oxidase protein targeting to peroxisome Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 10455 23986 Ensembl ENSG00000198721 ENSMUSG00000021417 UniProt O75521 Q9WUR2 RefSeq (mRNA) NM_001166010 NM_006117 NM_206836 NM_001110331 NM_001110332 NM_011868 RefSeq (protein) NP_001159482 NP_006108 NP_996667 NP_001103801 NP_035998 Location (UCSC) Chr 6: 4.12 – 4.14 Mb Chr 13: 35.16 – 35.21 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Peroxisomal 3,2-trans-enoyl-CoA isomerase** is an [enzyme](/source/Enzyme) that in humans is encoded by the *PECI* [gene](/source/Gene).[5][6]

PECI is an auxiliary enzyme that catalyzes an [isomerization](/source/Isomerization) step required for the beta-oxidation of [unsaturated fatty acids](/source/Unsaturated_fatty_acids).[supplied by OMIM][6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000198721](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000198721) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000021417](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000021417) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=10455). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=23986). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid10419495_5-0)** Geisbrecht BV, Zhang D, Schulz H, Gould SJ (Aug 1999). ["Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes"](https://doi.org/10.1074%2Fjbc.274.31.21797). *J Biol Chem*. **274** (31): 21797–803. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.31.21797](https://doi.org/10.1074%2Fjbc.274.31.21797). [PMID](/source/PMID_(identifier)) [10419495](https://pubmed.ncbi.nlm.nih.gov/10419495).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10455).

## Further reading

- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Suk K, Kim YH, Hwang DY, et al. (1999). "Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor". *Biochim. Biophys. Acta*. **1454** (1): 126–31. [doi](/source/Doi_(identifier)):[10.1016/s0925-4439(99)00033-2](https://doi.org/10.1016%2Fs0925-4439%2899%2900033-2). [PMID](/source/PMID_(identifier)) [10354522](https://pubmed.ncbi.nlm.nih.gov/10354522).

- Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". *Int. J. Cancer*. **83** (4): 456–64. [doi](/source/Doi_(identifier)):[10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5](https://doi.org/10.1002%2F%28SICI%291097-0215%2819991112%2983%3A4%3C456%3A%3AAID-IJC4%3E3.0.CO%3B2-5). [PMID](/source/PMID_(identifier)) [10508479](https://pubmed.ncbi.nlm.nih.gov/10508479). [S2CID](/source/S2CID_(identifier)) [21839750](https://api.semanticscholar.org/CorpusID:21839750).

- Wiemann S, Weil B, Wellenreuther R, et al. (2001). ["Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). *Genome Res*. **11** (3): 422–35. [doi](/source/Doi_(identifier)):[10.1101/gr.GR1547R](https://doi.org/10.1101%2Fgr.GR1547R). [PMC](/source/PMC_(identifier)) [311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID](/source/PMID_(identifier)) [11230166](https://pubmed.ncbi.nlm.nih.gov/11230166).

- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). ["Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732). *EMBO Rep*. **1** (3): 287–92. [doi](/source/Doi_(identifier)):[10.1093/embo-reports/kvd058](https://doi.org/10.1093%2Fembo-reports%2Fkvd058). [PMC](/source/PMC_(identifier)) [1083732](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732). [PMID](/source/PMID_(identifier)) [11256614](https://pubmed.ncbi.nlm.nih.gov/11256614).

- Suzuki Y, Tsunoda T, Sese J, et al. (2001). ["Identification and characterization of the potential promoter regions of 1031 kinds of human genes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311086). *Genome Res*. **11** (5): 677–84. [doi](/source/Doi_(identifier)):[10.1101/gr.gr-1640r](https://doi.org/10.1101%2Fgr.gr-1640r). [PMC](/source/PMC_(identifier)) [311086](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311086). [PMID](/source/PMID_(identifier)) [11337467](https://pubmed.ncbi.nlm.nih.gov/11337467).

- Janssen U, Stoffel W (2002). ["Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse"](https://doi.org/10.1074%2Fjbc.M110993200). *J. Biol. Chem*. **277** (22): 19579–84. [doi](/source/Doi_(identifier)):[10.1074/jbc.M110993200](https://doi.org/10.1074%2Fjbc.M110993200). [PMID](/source/PMID_(identifier)) [11916962](https://pubmed.ncbi.nlm.nih.gov/11916962).

- Wang Y, Han KJ, Pang XW, et al. (2002). ["Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies"](https://doi.org/10.4049%2Fjimmunol.169.2.1102). *J. Immunol*. **169** (2): 1102–9. [doi](/source/Doi_(identifier)):[10.4049/jimmunol.169.2.1102](https://doi.org/10.4049%2Fjimmunol.169.2.1102). [PMID](/source/PMID_(identifier)) [12097419](https://pubmed.ncbi.nlm.nih.gov/12097419).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Mungall AJ, Palmer SA, Sims SK, et al. (2003). ["The DNA sequence and analysis of human chromosome 6"](https://doi.org/10.1038%2Fnature02055). *Nature*. **425** (6960): 805–11. [Bibcode](/source/Bibcode_(identifier)):[2003Natur.425..805M](https://ui.adsabs.harvard.edu/abs/2003Natur.425..805M). [doi](/source/Doi_(identifier)):[10.1038/nature02055](https://doi.org/10.1038%2Fnature02055). [PMID](/source/PMID_(identifier)) [14574404](https://pubmed.ncbi.nlm.nih.gov/14574404).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Feng X, Chuhjo T, Sugimori C, et al. (2004). ["Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells"](https://doi.org/10.1182%2Fblood-2004-05-1839). *Blood*. **104** (8): 2425–31. [doi](/source/Doi_(identifier)):[10.1182/blood-2004-05-1839](https://doi.org/10.1182%2Fblood-2004-05-1839). [PMID](/source/PMID_(identifier)) [15217832](https://pubmed.ncbi.nlm.nih.gov/15217832).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

v t e PDB gallery 2cqu: Solution Structure of RSGI RUH-045, a Human Acyl-CoA Binding Protein 2f6q: The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)

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