# PDS5B

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Sister chromatid cohesion protein PDS5 homolog B''' '''(PDS5B)''' is a [protein](/source/protein) that in humans is encoded by the ''PDS5B'' [gene](/source/gene).<ref name="pmid8812419">{{cite journal |vauthors=Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J | title = Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13 | journal = Genomics | volume = 36 | issue = 1 | pages = 86–99 |date=Feb 1997 | pmid = 8812419 | doi =10.1006/geno.1996.0428  |display-authors=etal| doi-access = free }}</ref><ref name="pmid10215036">{{cite journal |vauthors=Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM | title = Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus | journal = J Steroid Biochem Mol Biol | volume = 68 | issue = 1–2 | pages = 41–50 |date=May 1999 | pmid = 10215036 | doi =10.1016/S0960-0760(98)00165-4  | s2cid = 32542980 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: APRIN androgen-induced proliferation inhibitor| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23047}}</ref> It is a regulatory subunit of the [Cohesin](/source/Cohesin) complex which mediates [sister chromatid cohesion](/source/Establishment_of_sister_chromatid_cohesion), homologous recombination and [DNA looping](/source/Topologically_associating_domain). The core cohesin complex is formed of SMC3, [SMC1](/source/SMC1A), [RAD21](/source/RAD21) and either [SA1](/source/STAG1) or [SA2](/source/STAG2). PDS5 associates with [WAPL](/source/WAPAL) to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by [ESCO1](/source/ESCO1) and [ESCO2](/source/ESCO2).

==References==
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Category:Genes mutated in mice
Category:Genes on human chromosome 13

{{gene-13-stub}}

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Adapted from the Wikipedia article [PDS5B](https://en.wikipedia.org/wiki/PDS5B) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/PDS5B?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.