# PCBP2

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/PCBP2
> Markdown URL: https://mediated.wiki/source/PCBP2.md
> Source: https://en.wikipedia.org/wiki/PCBP2
> Source revision: 1300846091
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Protein-coding gene in the species Homo sapiens

PCBP2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AXY, 2JZX, 2P2R, 2PQU, 2PY9 Identifiers Aliases PCBP2, HNRNPE2, HNRPE2, hnRNP-E2, poly(rC) binding protein 2 External IDs OMIM: 601210; MGI: 108202; HomoloGene: 74536; GeneCards: PCBP2; OMA:PCBP2 - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,452,102 bp[1] End 53,481,162 bp[1] Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 57.61 cM Start 102,470,539 bp[2] End 102,500,061 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone stromal cell of endometrium left testis right testis left ovary right adrenal cortex left lobe of thyroid gland right lobe of thyroid gland right ovary Top expressed in neural layer of retina epiblast hand ventricular zone somite molar thymus abdominal wall tail of embryo endocardial cushion More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA binding enzyme binding nucleic acid binding ubiquitin protein ligase binding protein binding RNA binding C-rich single-stranded DNA binding Cellular component extracellular exosome membrane focal adhesion nucleoplasm cytoplasm nucleus cytosol postsynaptic density Biological process mRNA splicing, via spliceosome negative regulation of defense response to virus proteasome-mediated ubiquitin-dependent protein catabolic process defense response to virus mRNA metabolic process negative regulation of type I interferon production immune system process innate immune response viral RNA genome replication IRES-dependent viral translational initiation RNA metabolic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 5094 18521 Ensembl ENSG00000197111 ENSMUSG00000056851 UniProt Q15366 Q61990 RefSeq (mRNA) NM_031989 NM_001098620 NM_001128911 NM_001128912 NM_001128913 NM_001128914 NM_005016 NM_001103165 NM_001103166 NM_001174073 NM_011042 RefSeq (protein) NP_001092090 NP_001122383 NP_001122384 NP_001122385 NP_001122386 NP_005007 NP_114366 NP_001096635 NP_001096636 NP_001167544 NP_035172 NP_001361700 Location (UCSC) Chr 12: 53.45 – 53.48 Mb Chr 15: 102.47 – 102.5 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Poly(rC)-binding protein 2** is a [protein](/source/Protein) that in humans is encoded by the *PCBP2* [gene](/source/Gene).[5]

## Function

The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three [K-homologous (KH) domains](/source/KH_domain) which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.[6]

In humans, the PCBP2 gene overlaps with [TUC338](/source/TUC338), a transcribed [ultra-conserved element](/source/Ultra-conserved_element) implicated in [Hepatocellular carcinoma](/source/Hepatocellular_carcinoma).[7]

## Interactions

PCBP2 has been shown to [interact](/source/Protein-protein_interaction) with [HNRPK](/source/HNRPK),[8] [PTBP1](/source/PTBP1), and [HNRNPL](/source/HNRNPL).[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000197111](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000197111) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000056851](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000056851) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=5094). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=18521). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8833161_5-0)** Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". *Genomics*. **32** (2): 297–8. [doi](/source/Doi_(identifier)):[10.1006/geno.1996.0121](https://doi.org/10.1006%2Fgeno.1996.0121). [PMID](/source/PMID_(identifier)) [8833161](https://pubmed.ncbi.nlm.nih.gov/8833161).

1. **[^](#cite_ref-entrez_6-0)** ["Entrez Gene: PCBP2 poly(rC) binding protein 2"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5094). [Archived](https://web.archive.org/web/20240430040833/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5094) from the original on 2024-04-30. Retrieved 2017-09-07.

1. **[^](#cite_ref-Bra11_7-0)** Braconi C, Valeri N, Kogure T, Gasparini P, Huang N, Nuovo GJ, Terracciano L, Croce CM, Patel T (2011-01-11). ["Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021052). *Proceedings of the National Academy of Sciences of the United States of America*. **108** (2): 786–91. [Bibcode](/source/Bibcode_(identifier)):[2011PNAS..108..786B](https://ui.adsabs.harvard.edu/abs/2011PNAS..108..786B). [doi](/source/Doi_(identifier)):[10.1073/pnas.1011098108](https://doi.org/10.1073%2Fpnas.1011098108). [PMC](/source/PMC_(identifier)) [3021052](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021052). [PMID](/source/PMID_(identifier)) [21187392](https://pubmed.ncbi.nlm.nih.gov/21187392).

1. ^ [***a***](#cite_ref-pmid10772858_8-0) [***b***](#cite_ref-pmid10772858_8-1) Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". *J. Mol. Biol*. **298** (3): 395–405. [doi](/source/Doi_(identifier)):[10.1006/jmbi.2000.3687](https://doi.org/10.1006%2Fjmbi.2000.3687). [PMID](/source/PMID_(identifier)) [10772858](https://pubmed.ncbi.nlm.nih.gov/10772858).

## Further reading

- Kiledjian M, Wang X, Liebhaber SA (1995). ["Identification of two KH domain proteins in the alpha-globin mRNP stability complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394520). *EMBO J*. **14** (17): 4357–64. [doi](/source/Doi_(identifier)):[10.1002/j.1460-2075.1995.tb00110.x](https://doi.org/10.1002%2Fj.1460-2075.1995.tb00110.x). [PMC](/source/PMC_(identifier)) [394520](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394520). [PMID](/source/PMID_(identifier)) [7556077](https://pubmed.ncbi.nlm.nih.gov/7556077).

- Leffers H, Dejgaard K, Celis JE (1995). "Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains". *Eur. J. Biochem*. **230** (2): 447–53. [doi](/source/Doi_(identifier)):[10.1111/j.1432-1033.1995.tb20581.x](https://doi.org/10.1111%2Fj.1432-1033.1995.tb20581.x). [PMID](/source/PMID_(identifier)) [7607214](https://pubmed.ncbi.nlm.nih.gov/7607214).

- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

- Blyn LB, Swiderek KM, Richards O, Stahl DC, Semler BL, Ehrenfeld E (1996). ["Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38293). *Proc. Natl. Acad. Sci. U.S.A*. **93** (20): 11115–20. [Bibcode](/source/Bibcode_(identifier)):[1996PNAS...9311115B](https://ui.adsabs.harvard.edu/abs/1996PNAS...9311115B). [doi](/source/Doi_(identifier)):[10.1073/pnas.93.20.11115](https://doi.org/10.1073%2Fpnas.93.20.11115). [PMC](/source/PMC_(identifier)) [38293](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38293). [PMID](/source/PMID_(identifier)) [8855318](https://pubmed.ncbi.nlm.nih.gov/8855318).

- Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stévenin J, Horak I (1996). ["The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146158). *Nucleic Acids Res*. **24** (19): 3821–8. [doi](/source/Doi_(identifier)):[10.1093/nar/24.19.3821](https://doi.org/10.1093%2Fnar%2F24.19.3821). [PMC](/source/PMC_(identifier)) [146158](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146158). [PMID](/source/PMID_(identifier)) [8871564](https://pubmed.ncbi.nlm.nih.gov/8871564).

- Blyn LB, Towner JS, Semler BL, Ehrenfeld E (1997). ["Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC191892). *J. Virol*. **71** (8): 6243–6. [doi](/source/Doi_(identifier)):[10.1128/JVI.71.8.6243-6246.1997](https://doi.org/10.1128%2FJVI.71.8.6243-6246.1997). [PMC](/source/PMC_(identifier)) [191892](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC191892). [PMID](/source/PMID_(identifier)) [9223526](https://pubmed.ncbi.nlm.nih.gov/9223526).

- Kiledjian M, DeMaria CT, Brewer G, Novick K (1997). ["Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232339). *Mol. Cell. Biol*. **17** (8): 4870–6. [doi](/source/Doi_(identifier)):[10.1128/MCB.17.8.4870](https://doi.org/10.1128%2FMCB.17.8.4870). [PMC](/source/PMC_(identifier)) [232339](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232339). [PMID](/source/PMID_(identifier)) [9234743](https://pubmed.ncbi.nlm.nih.gov/9234743).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Czyzyk-Krzeska MF, Bendixen AC (1999). "Identification of the poly(C) binding protein in the complex associated with the 3' untranslated region of erythropoietin messenger RNA". *Blood*. **93** (6): 2111–20. [doi](/source/Doi_(identifier)):[10.1182/blood.V93.6.2111.406k24_2111_2120](https://doi.org/10.1182%2Fblood.V93.6.2111.406k24_2111_2120). [PMID](/source/PMID_(identifier)) [10068686](https://pubmed.ncbi.nlm.nih.gov/10068686).

- Wang Z, Day N, Trifillis P, Kiledjian M (1999). ["An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84253). *Mol. Cell. Biol*. **19** (7): 4552–60. [doi](/source/Doi_(identifier)):[10.1128/MCB.19.7.4552](https://doi.org/10.1128%2FMCB.19.7.4552). [PMC](/source/PMC_(identifier)) [84253](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84253). [PMID](/source/PMID_(identifier)) [10373504](https://pubmed.ncbi.nlm.nih.gov/10373504).

- Makeyev AV, Chkheidze AN, Liebhaber SA (1999). ["A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog"](https://doi.org/10.1074%2Fjbc.274.35.24849). *J. Biol. Chem*. **274** (35): 24849–57. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.35.24849](https://doi.org/10.1074%2Fjbc.274.35.24849). [PMID](/source/PMID_(identifier)) [10455157](https://pubmed.ncbi.nlm.nih.gov/10455157).

- Kim JH, Hahm B, Kim YK, Choi M, Jang SK (2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". *J. Mol. Biol*. **298** (3): 395–405. [doi](/source/Doi_(identifier)):[10.1006/jmbi.2000.3687](https://doi.org/10.1006%2Fjmbi.2000.3687). [PMID](/source/PMID_(identifier)) [10772858](https://pubmed.ncbi.nlm.nih.gov/10772858).

- Makeyev AV, Liebhaber SA (2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". *Genomics*. **67** (3): 301–16. [doi](/source/Doi_(identifier)):[10.1006/geno.2000.6244](https://doi.org/10.1006%2Fgeno.2000.6244). [PMID](/source/PMID_(identifier)) [10936052](https://pubmed.ncbi.nlm.nih.gov/10936052).

- Chang CJ, Luh HW, Wang SH, Lin HJ, Lee SC, Hu ST (2002). ["The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with dengue virus core protein"](http://ntur.lib.ntu.edu.tw//handle/246246/163267). *DNA Cell Biol*. **20** (9): 569–77. [doi](/source/Doi_(identifier)):[10.1089/104454901317094981](https://doi.org/10.1089%2F104454901317094981). [PMID](/source/PMID_(identifier)) [11747608](https://pubmed.ncbi.nlm.nih.gov/11747608). [Archived](https://web.archive.org/web/20230928095531/http://ntur.lib.ntu.edu.tw//handle/246246/163267) from the original on 2023-09-28. Retrieved 2022-10-14.

- Yeap BB, Voon DC, Vivian JP, McCulloch RK, Thomson AM, Giles KM, Czyzyk-Krzeska MF, Furneaux H, Wilce MC, Wilce JA, Leedman PJ (2002). ["Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA"](https://doi.org/10.1074%2Fjbc.M202883200). *J. Biol. Chem*. **277** (30): 27183–92. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202883200](https://doi.org/10.1074%2Fjbc.M202883200). [PMID](/source/PMID_(identifier)) [12011088](https://pubmed.ncbi.nlm.nih.gov/12011088).

- Walter BL, Parsley TB, Ehrenfeld E, Semler BL (2002). ["Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC136902). *J. Virol*. **76** (23): 12008–22. [doi](/source/Doi_(identifier)):[10.1128/JVI.76.23.12008-12022.2002](https://doi.org/10.1128%2FJVI.76.23.12008-12022.2002). [PMC](/source/PMC_(identifier)) [136902](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC136902). [PMID](/source/PMID_(identifier)) [12414943](https://pubmed.ncbi.nlm.nih.gov/12414943).

- Abraham RS, Geyer SM, Price-Troska TL, Allmer C, Kyle RA, Gertz MA, Fonseca R (2003). "Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL)". *Blood*. **101** (10): 3801–8. [doi](/source/Doi_(identifier)):[10.1182/blood-2002-09-2707](https://doi.org/10.1182%2Fblood-2002-09-2707). [PMID](/source/PMID_(identifier)) [12515719](https://pubmed.ncbi.nlm.nih.gov/12515719). [S2CID](/source/S2CID_(identifier)) [38371635](https://api.semanticscholar.org/CorpusID:38371635).

- Pickering BM, Mitchell SA, Evans JR, Willis AE (2003). ["Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140511). *Nucleic Acids Res*. **31** (2): 639–46. [doi](/source/Doi_(identifier)):[10.1093/nar/gkg146](https://doi.org/10.1093%2Fnar%2Fgkg146). [PMC](/source/PMC_(identifier)) [140511](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140511). [PMID](/source/PMID_(identifier)) [12527772](https://pubmed.ncbi.nlm.nih.gov/12527772).

v t e PDB gallery 1ztg: human alpha polyC binding protein KH1 2axy: Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Gene-12-stub)
- [t](/source/Template_talk%3AGene-12-stub)
- [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:Gene-12-stub)

---
Adapted from the Wikipedia article [PCBP2](https://en.wikipedia.org/wiki/PCBP2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/PCBP2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.