# P87PIKAP

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> Source: https://en.wikipedia.org/wiki/P87PIKAP
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{{Short description|Mammalian protein found in Homo sapiens}}
{{infobox protein
|Name='''Phosphoinositide-3-kinase adapter protein of 87 kDa'''
|caption=
|image=
|width=
|HGNCid=27101
|Symbol=p87<sup>PIKAP</sup>
|AltSymbols=p84,PIK3R6
|EntrezGene=146850
|UniProt=Q5UE93
|OMIM=611462
|PDB=
|ECnumber=
|Chromosome=17
|Arm=p
|Band=13.1
|LocusSupplementaryData=
}}
Within [molecular](/source/molecular_biology) and [cell biology](/source/cell_biology), '''p87<sup>PIKAP</sup>''' is a regulatory subunit of the type IB [Phosphoinositide](/source/Phosphoinositide) 3-Kinase p110γ that is highly expressed in the [heart](/source/heart) and is present in [dendritic cells](/source/dendritic_cells), [macrophages](/source/macrophages), and [neutrophils](/source/neutrophils).<ref name="pmid16476736">{{cite journal | vauthors = Voigt P, Dorner MB, Schaefer M | title = Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B | journal = The Journal of Biological Chemistry | volume = 281 | issue = 15 | pages = 9977–86 | year = 2006 | pmid = 16476736 | doi = 10.1074/jbc.M512502200 | doi-access = free }}</ref>
It is also referred to as p84 and p87.<ref name="pmid19906996">{{cite journal | vauthors = Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B | display-authors = 6 | title = Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20312–7 | year = 2009 | pmid = 19906996 | pmc = 2787109 | doi = 10.1073/pnas.0905506106 | bibcode = 2009PNAS..10620312K | doi-access = free }}</ref> Some studies have found P87PIKAP to have a role in [carcinogenesis](/source/carcinogenesis).<ref>{{cite journal|title=Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis|url=https://www.nature.com/onc/journal/v31/n18/pdf/onc2011414a.pdf?origin=ppub|first1=JA |last1=Brazzatti|display-authors=etal|journal=Oncogene|date=2012|volume=31|issue = 18|pages=2350–2361|doi=10.1038/onc.2011.414|pmid = 21996737|s2cid = 24708435|doi-access=free}}</ref>

== References ==
{{reflist}}

thumb|300px|The context of the function of p87.

{{protein-stub}}

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Adapted from the Wikipedia article [P87PIKAP](https://en.wikipedia.org/wiki/P87PIKAP) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/P87PIKAP?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.