# P2RX6

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Protein-coding gene in the species Homo sapiens

P2RX6 Identifiers Aliases P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6 External IDs OMIM: 608077; MGI: 1337113; HomoloGene: 3975; GeneCards: P2RX6; OMA:P2RX6 - orthologs Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 21,009,808 bp[1] End 21,028,013 bp[1] Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,379,749 bp[2] End 17,395,664 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh right frontal lobe right uterine tube Brodmann area 9 apex of heart spleen anterior cingulate cortex anterior pituitary prefrontal cortex Top expressed in facial motor nucleus muscle of thigh skeletal muscle tissue soleus muscle quadriceps femoris muscle morula medial head of gastrocnemius muscle temporal muscle masseter muscle anterior horn of spinal cord More reference expression data BioGPS More reference expression data Gene ontology Molecular function channel activity purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ion channel activity identical protein binding ATP binding transmembrane signaling receptor activity ATP-gated ion channel activity Cellular component cytoplasm integral component of membrane membrane integral component of nuclear inner membrane integral component of plasma membrane cell junction plasma membrane postsynapse postsynaptic density soma dendritic spine parallel fiber to Purkinje cell synapse glutamatergic synapse integral component of postsynaptic specialization membrane Biological process response to ATP muscle contraction ion transport cation transmembrane transport protein homooligomerization signal transduction blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential protein heterooligomerization cation transport ion transmembrane transport Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 9127 18440 Ensembl ENSG00000099957 ENSMUSG00000022758 UniProt O15547 O54803 RefSeq (mRNA) NM_001159554 NM_005446 NM_001349874 NM_001349875 NM_001349876 NM_001394691 NM_001394692 NM_001394693 NM_001394694 NM_001394695 NM_001394696 NM_001394697 NM_001159561 NM_011028 RefSeq (protein) NP_001153026 NP_005437 NP_001336803 NP_001336804 NP_001336805 NP_001153033 NP_035158 Location (UCSC) Chr 22: 21.01 – 21.03 Mb Chr 16: 17.38 – 17.4 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**P2X purinoceptor 6** is a [protein](/source/Protein) that in humans is encoded by the *P2RX6* [gene](/source/Gene).[5][6][7][8]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[8]

## See also

- [Purinergic receptor](/source/Purinergic_receptor)

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000099957](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000099957) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000022758](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000022758) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=9127). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=18440). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid9242461_5-0)** Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". *Cancer Res*. **57** (15): 3281–7. [PMID](/source/PMID_(identifier)) [9242461](https://pubmed.ncbi.nlm.nih.gov/9242461).

1. **[^](#cite_ref-pmid10591208_6-0)** Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). ["The DNA sequence of human chromosome 22"](https://doi.org/10.1038%2F990031). *Nature*. **402** (6761): 489–95. [Bibcode](/source/Bibcode_(identifier)):[1999Natur.402..489D](https://ui.adsabs.harvard.edu/abs/1999Natur.402..489D). [doi](/source/Doi_(identifier)):[10.1038/990031](https://doi.org/10.1038%2F990031). [PMID](/source/PMID_(identifier)) [10591208](https://pubmed.ncbi.nlm.nih.gov/10591208).

1. **[^](#cite_ref-pmid8786426_7-0)** Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). ["Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578782). *J Neurosci*. **16** (8): 2495–507. [doi](/source/Doi_(identifier)):[10.1523/JNEUROSCI.16-08-02495.1996](https://doi.org/10.1523%2FJNEUROSCI.16-08-02495.1996). [PMC](/source/PMC_(identifier)) [6578782](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578782). [PMID](/source/PMID_(identifier)) [8786426](https://pubmed.ncbi.nlm.nih.gov/8786426).

1. ^ [***a***](#cite_ref-entrez_8-0) [***b***](#cite_ref-entrez_8-1) ["Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9127).

## Further reading

- Khakh BS, Burnstock G, Kennedy C, et al. (2001). "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits". *Pharmacol. Rev*. **53** (1): 107–18. [doi](/source/Doi_(identifier)):[10.1016/S0031-6997(24)01482-0](https://doi.org/10.1016%2FS0031-6997%2824%2901482-0). [PMID](/source/PMID_(identifier)) [11171941](https://pubmed.ncbi.nlm.nih.gov/11171941).

- Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain". *Biochem. Biophys. Res. Commun*. **223** (2): 456–60. [doi](/source/Doi_(identifier)):[10.1006/bbrc.1996.0915](https://doi.org/10.1006%2Fbbrc.1996.0915). [PMID](/source/PMID_(identifier)) [8670303](https://pubmed.ncbi.nlm.nih.gov/8670303).

- Glass R, Loesch A, Bodin P, Burnstock G (2002). ["P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146110). *Cell. Mol. Life Sci*. **59** (5): 870–81. [doi](/source/Doi_(identifier)):[10.1007/s00018-002-8474-y](https://doi.org/10.1007%2Fs00018-002-8474-y). [PMC](/source/PMC_(identifier)) [11146110](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146110). [PMID](/source/PMID_(identifier)) [12088286](https://pubmed.ncbi.nlm.nih.gov/12088286). [S2CID](/source/S2CID_(identifier)) [16519633](https://api.semanticscholar.org/CorpusID:16519633).

- Maguire PB, Wynne KJ, Harney DF, et al. (2003). ["Identification of the phosphotyrosine proteome from thrombin activated platelets"](https://doi.org/10.1002%2F1615-9861%28200206%292%3A6%3C642%3A%3AAID-PROT642%3E3.0.CO%3B2-I). *Proteomics*. **2** (6): 642–8. [doi](/source/Doi_(identifier)):[10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I](https://doi.org/10.1002%2F1615-9861%28200206%292%3A6%3C642%3A%3AAID-PROT642%3E3.0.CO%3B2-I). [PMID](/source/PMID_(identifier)) [12112843](https://pubmed.ncbi.nlm.nih.gov/12112843). [S2CID](/source/S2CID_(identifier)) [22665513](https://api.semanticscholar.org/CorpusID:22665513).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Collins JE, Wright CL, Edwards CA, et al. (2005). ["A genome annotation-driven approach to cloning the human ORFeome"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545604). *Genome Biol*. **5** (10): R84. [doi](/source/Doi_(identifier)):[10.1186/gb-2004-5-10-r84](https://doi.org/10.1186%2Fgb-2004-5-10-r84). [PMC](/source/PMC_(identifier)) [545604](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545604). [PMID](/source/PMID_(identifier)) [15461802](https://pubmed.ncbi.nlm.nih.gov/15461802).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Barrera NP, Ormond SJ, Henderson RM, et al. (2005). ["Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize"](https://doi.org/10.1074%2Fjbc.M412265200). *J. Biol. Chem*. **280** (11): 10759–65. [doi](/source/Doi_(identifier)):[10.1074/jbc.M412265200](https://doi.org/10.1074%2Fjbc.M412265200). [PMID](/source/PMID_(identifier)) [15657042](https://pubmed.ncbi.nlm.nih.gov/15657042).

- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). ["Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). *Genome Res*. **16** (1): 55–65. [doi](/source/Doi_(identifier)):[10.1101/gr.4039406](https://doi.org/10.1101%2Fgr.4039406). [PMC](/source/PMC_(identifier)) [1356129](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). [PMID](/source/PMID_(identifier)) [16344560](https://pubmed.ncbi.nlm.nih.gov/16344560).

## External links

- [P2RXL1+protein,+human](https://meshb.nlm.nih.gov/record/ui?name=P2RXL1+protein%2C+human) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

v t e Ion channel, cell surface receptor: ligand-gated ion channels Cys-loop receptors 5-HT/serotonin 5-HT3 A B C D E GABA GABAA α1 α2 α3 α4 α5 α6 β1 β2 β3 γ1 γ2 γ3 δ ε π θ GABAA-ρ ρ1 ρ2 ρ3 Glycine α1 α2 α3 α4 β Nicotinic acetylcholine monomers: α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers: (α3)2(β4)3 (α4)2(β2)3 (α7)5 (α1)2(β4)3 - Ganglion type (α1)2β1δε - Muscle type Zinc Zinc-activated Ionotropic glutamates Ligand-gated only AMPA (1 2 3 4) Kainate 1 2 3 4 5 Voltage- and ligand-gated NMDA 1 2A 2B 2C 2D 3A 3B L1A L1B ‘Orphan’ GluD δ1 δ2 ATP-gated channels Purinergic receptors P2X 1 2 3 4 5 6 7

v t e Purine receptor modulators Receptor (ligands) P0 (adenine) Agonists: 8-Aminoadenine Adenine P1 (adenosine) Agonists: 2-(1-Hexynyl)-N-methyladenosine 2-Cl-IB-MECA 2-Chloroadenosine 2'-MeCCPA 4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil 5'-N-ethylcarboxamidoadenosine Adenosine ADP AMP Apadenoson ATL-146e ATP BAY 60–6583 Binodenoson Capadenoson CGS-21680 CP-532,903 CV-1808 Evodenoson GR 79236 HENECA LUF-5835 LUF-5845 N6-Cyclopentyladenosine Namodenoson NECA Neladenoson dalanate Piclidenoson Regadenoson SDZ WAG 994 Selodenoson Sonedenoson Tecadenoson Trabodenoson UK-432,097 YZG-331 Antagonists: 3-Chlorostyrylcaffeine (CSC) 7-Methylxanthine 8-Chlorotheophylline 8-Phenyl-1,3-dipropylxanthine 8-Phenyltheophylline Acefylline Aminophylline ATL-444 AZD-4635 Bamifylline Cafedrine Caffeine Caffeine citrate Cartazolate CGH-2466 CGS-15943 Choline theophyllinate Ciforadenant CPX CVT-6883 Dimethazan DMPX DPCPX Dyphylline Enprofylline Etazolate Etrumadenant Fenethylline IBMX Imaradenant Inupadenant ISAM-140 ISAM-R316 Isovaleric acid Istradefylline KF-26777 Lu AA41063 Lu AA47070 MRE3008F20 MRS-1191 MRS-1220 MRS-1334 MRS-1523 MRS-1706 MRS-1754 MRS-3777 MSX-2 MSX-3 MSX-4 Muvadenant Paraxanthine Pentoxifylline Preladenant Propentofylline Proxyphylline PSB-10 PSB-11 PSB-36 PSB-603 PSB-788 PSB-1115 PSB-1901 Reversine Rolofylline SCH-442,416 SCH-58261 Sipagladenant Taminadenant Theacrine Theobromine Theodrenaline Theophylline Tozadenant Tracazolate Vipadenant VUF-5574 ZM-241,385 P2 (nucleotide) P2X (ATPTooltip Adenosine triphosphate) Agonists: 2-Me-SATP α,β-Me-ATP Adenosine ADP AMP Ap4A Ap5A ATP ATPγS BzATP Cibacron blue CTP D-β,γ-Me-ATP GTP HT-AMP Ivermectin L-β,γ-Me-ATP MRS-2219 PAPET-ATP UTP Zinc Antagonists: 5-BDBD A-317491 A-438079 A-740003 A-804598 A-839977 AF-353 AZ-10606120 AZ-11645373 BBG Calcium Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans blue Gefapixant GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159 NF-023 NF-110 NF-157 NF-279 NF-449 Opiranserin (VVZ-149) Oxidized-ATP Phenol Red Phenolphthalein PPADS PPNDS PSB-12062 Puerarin (Radix puerariae) Purotoxin 1 RB-2 Ro 0437626 Ro 51 RO-3 Sodium ferulate (Angelica sinensis, Ligusticum wallichii) Suramin TC-P 262 Tetramethylpyrazine (ligustrazine) (Ligusticum wallichii) TNP-ATP Zinc P2Y Agonists: 2-Me-SADP 2-Me-SATP 2-Thio-UTP 5-Br-UDP 5-OMe-UDP α,β-Me-ATP Adenosine ADP ADPβS Ap3A AR-C 67085MX ATP ATPγS CTP dATP Denufosol Diquafosol IDP ITP INS-365 INS-37217 MRS-2365 MRS-2690 MRS-2693 MRS-2768 MRS-2957 MRS-4062 NF-546 PAPET-ATP PSB-0474 PSB-1114 UDP UDPβS UDP-galactose UDP-glucose UDP-N-acetylglucosamine Up3U UTP UTPγS Antagonists: 2-Me-SAMP A3P5PS AMPαS Ap4A AR-C 66096 AR-C 67085MX AR-C 69931MX AR-C 118925XX ATP BzATP C1330-7 Cangrelor Clopidogrel Elinogrel Ip5I MRS-2179 MRS-2211 MRS-2279 MRS-2395 MRS-2500 MRS-2578 NF-157 NF-340 PIT PPADS Prasugrel PSB-0739 RB-2 Regrelor Suramin Ticagrelor Ticlopidine UDP Transporter (blockers) CNTsTooltip Concentrative nucleoside transporters 6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone ENTsTooltip Equilibrative nucleoside transporters Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline PMATTooltip Plasma membrane monoamine transporter Decynium-22 Enzyme (inhibitors) XOTooltip Xanthine oxidase Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat Others Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others Others Precursors: Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine IMP IDP ITP Ribose Uracil Uridine UMP UDP UTP Others: Chrysophanol (rhubarb) See also: Receptor/signaling modulators

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Adapted from the Wikipedia article [P2RX6](https://en.wikipedia.org/wiki/P2RX6) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/P2RX6?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.