# Otolin

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Otolin
> Markdown URL: https://mediated.wiki/source/Otolin.md
> Source: https://en.wikipedia.org/wiki/Otolin
> Source revision: 1314672141
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

**Otolin** is a [glycoprotein](/source/Glycoprotein) found in the [vertebrate](/source/Vertebrate) [inner ear](/source/Inner_ear).[1]

## Modifications

Otolin is modified after it is translated, with [hydroxylated prolines](/source/Hydroxylated_proline) and two [glycosylated lysines](/source/Glycosylated_lysine) with [glucosyl-galactosyl](/source/Glucosyl-galactosyl) groups.[1]

## Substructure

The gene for otolin in mice is on chromosome 3E12. In humans it is located at 3q26.1 At the N-terminal end there is a [signal peptide](/source/Signal_peptide). The N-terminal end has four [cysteine residues](/source/Cysteine_residue). Adjacent to this is a stiff [collagen](/source/Collagen) domain with 75 Gly-X-Y repeats. It also contains a cysteine residue, and in human otolin, there are four cystein residues in this domain. At the opposite end is the C1q domain. The *otolin* gene in mammals contains four [introns](/source/Intron) and five [exons](/source/Exon).[1]

## Superstructure

Otolin combines with several other otolin molecules to form an [oligomer](/source/Oligomer), probably a trimer. It also binds to [otoconin-90](/source/Otoconin-90) and [cerebellin-1](/source/Cerebellin-1).[1]

## Production

Otolin is produced by the [vestibular support cells](/source/Vestibular_support_cell) in the [utricle](/source/Utricle_(ear)), [saccule](/source/Saccule), the three [semicircular canal cristae](/source/Semicircular_canal_cristae), and the [tectorial membrane](/source/Tectorial_membrane). In [teleosts](/source/Teleost) (fish), otolin is found in the [otolith](/source/Otolith) and it is required to anchor the otolith in position.[1]

## References

1. Deans, Michael R.; Peterson, Jonathan M.; Wong, G. William; Hulmes, David John Stuart (15 September 2010). "Mammalian Otolin: A Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-1". *PLOS ONE*. **5** (9). [Bibcode:2010PLoSO...512765D](https://ui.adsabs.harvard.edu/abs/2010PLoSO...512765D). [doi:10.1371/journal.pone.0012765](https://doi.org/10.1371/journal.pone.0012765). [PMC 2939893](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939893). [PMID 20856818](https://pubmed.ncbi.nlm.nih.gov/20856818). [S2CID 8886304](https://api.semanticscholar.org/CorpusID:8886304)

---
Adapted from the Wikipedia article [Otolin](https://en.wikipedia.org/wiki/Otolin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Otolin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.