# Organification

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**Organification** is a biochemical process that takes place in the [thyroid](/source/Thyroid) gland. It is the incorporation of [iodine](/source/Iodine) into [thyroglobulin](/source/Thyroglobulin) for the production of thyroid hormone, a step done after the [oxidation](/source/Oxidation) of [iodide](/source/Iodide) by the enzyme [thyroid peroxidase](/source/Thyroid_peroxidase) (TPO)[1] Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".[2]

[Thionamides](/source/Thioamide) can block organification.[3]

## References

1. Shargel L, Mutnick AH, Souney PF (May 2007). *Comprehensive Pharmacy Review*. Lippincott Williams and Wilkins. p. 1181. ISBN 978-0-7817-7403-1.

1. Molinam PE, Ashman R. *Endocrine Physiology*. Third ed. McGraw Hill Professional. p. 81. ISBN 978-0-07-161302-6.

1. ["Thionamides"](https://www.sciencedirect.com/science/article/pii/B9780444537171015377). *Meyler's Side Effects of Drugs*. Sixteenth ed. Oxford: Elsevier. January 2016. pp. 874–889. [doi:10.1016/b978-0-444-53717-1.01537-7](https://doi.org/10.1016/b978-0-444-53717-1.01537-7). ISBN 978-0-444-53716-4. Retrieved 2021-02-18.

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