# Opigolix

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Opigolix
> Markdown URL: https://mediated.wiki/source/Opigolix.md
> Source: https://en.wikipedia.org/wiki/Opigolix
> Source revision: 1328695333
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Chemical compound}}
{{Drugbox
| Verifiedfields =
| Watchedfields =
| verifiedrevid =
| IUPAC_name = (2''R'')-''N''<nowiki>'</nowiki>-[5-[3-(2,5-difluorophenyl)-2-(1,3-dihydrobenzimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide
| image = Opigolix.svg
| image_class = skin-invert-image
| width = 250px

<!--Clinical data-->
| tradename =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration = [By mouth](/source/Oral_administration)
| class = [GnRH modulator](/source/GnRH_modulator); [GnRH antagonist](/source/GnRH_antagonist); [Antigonadotropin](/source/Antigonadotropin)

<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 912587-25-8
| CAS_supplemental =
| ATC_prefix =
| ATC_suffix =
| ATC_supplemental =
| PubChem = 11977994
| IUPHAR_ligand =
| DrugBank_Ref =
| DrugBank =
| ChemSpiderID_Ref =
| ChemSpiderID =
| UNII = VQ6CK0CITA
| KEGG = D11351
| ChEBI =
| ChEMBL =
| synonyms = ASP-1707

<!--Chemical data-->
| C=25 | H=19 | F=3 | N=4 | O=5 | S=1
| SMILES = C[C@@H](O)/C(N)=N/S(=O)(=O)c1cc(C(=O)C(C(=O)c2cc(F)ccc2F)=C2Nc3ccccc3N2)ccc1F
| StdInChI_Ref =
| StdInChI = 1S/C25H19F3N4O5S/c1-12(33)24(29)32-38(36,37)20-10-13(6-8-17(20)28)22(34)21(23(35)15-11-14(26)7-9-16(15)27)25-30-18-4-2-3-5-19(18)31-25/h2-12,30-31,33H,1H3,(H2,29,32)/t12-/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = CWNLBPBIFALUQD-GFCCVEGCSA-N
}}

'''Opigolix''' ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}; developmental code name '''ASP-1707''') is a [small-molecule](/source/small-molecule), [non-peptide](/source/non-peptide), [orally active](/source/oral_administration) [gonadotropin-releasing hormone antagonist](/source/gonadotropin-releasing_hormone_antagonist) (GnRH antagonist) which was under development by [Astellas Pharma](/source/Astellas_Pharma) for the treatment of [endometriosis](/source/endometriosis) and [rheumatoid arthritis](/source/rheumatoid_arthritis).<ref name="AdisInsight">{{Cite web |title=Opigolix - Astellas Pharma - AdisInsight |url=https://adisinsight.springer.com/drugs/800032657}}</ref><ref name="pmid25581052">{{Cite journal |vauthors=Ezzati M, Carr BR |year=2015 |title=Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain |journal=Women's Health |volume=11 |issue=1 |pages=19–28 |doi=10.2217/whe.14.68 |pmid=25581052 |doi-access=free}}</ref> It was also under investigation for the treatment of [prostate cancer](/source/prostate_cancer).<ref name="AdisInsight" /> It reached [phase II](/source/Phases_of_clinical_research) [clinical trial](/source/clinical_trial)s for both endometriosis and rheumatoid arthritis prior to the discontinuation of its development in April 2018.<ref name="AdisInsight" />

==See also==
* [Gonadotropin-releasing hormone receptor § Antagonists](/source/Gonadotropin-releasing_hormone_receptor)

==References==
{{Reflist}}

==External links==
* [https://adisinsight.springer.com/drugs/800032657 Opigolix - AdisInsight]

{{GnRH and gonadotropins}}
{{GnRH and gonadotropin receptor modulators}}

Category:Abandoned drugs
Category:Secondary alcohols
Category:Amidines
Category:Benzimidazoles
Category:Fluoroarenes
Category:Gonadotropin-releasing hormone antagonists
Category:Aromatic ketones

{{Genito-urinary-drug-stub}}

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Adapted from the Wikipedia article [Opigolix](https://en.wikipedia.org/wiki/Opigolix) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Opigolix?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.