# ORAI2

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**Protein orai-2** is a [protein](/source/Protein) that in [humans](/source/Humans) is encoded by the *ORAI2* [gene](/source/Gene).[1][2]

## References

1. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". *Nature*. **441** (7090): 179–85. [Bibcode:2006Natur.441..179F](https://ui.adsabs.harvard.edu/abs/2006Natur.441..179F). [doi:10.1038/nature04702](https://doi.org/10.1038/nature04702). [PMID 16582901](https://pubmed.ncbi.nlm.nih.gov/16582901). [S2CID 1605392](https://api.semanticscholar.org/CorpusID:1605392)

1. ["Entrez Gene: TMEM142B transmembrane protein 142B"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=80228)

## Further reading

- DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.". *J. Biol. Chem.*. **282** (24): 17548–56. [doi:10.1074/jbc.M611374200](https://doi.org/10.1074/jbc.M611374200). [PMID 17452328](https://pubmed.ncbi.nlm.nih.gov/17452328)
- Mercer JC; Dehaven WI; Smyth JT et al. (2006). "Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1". *J. Biol. Chem.*. **281** (34): 24979–90. [doi:10.1074/jbc.M604589200](https://doi.org/10.1074/jbc.M604589200). [PMC 1633822](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633822). [PMID 16807233](https://pubmed.ncbi.nlm.nih.gov/16807233)
- Wan D; Gong Y; Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". *Proc. Natl. Acad. Sci. U.S.A.*. **101** (44): 15724–9. [Bibcode:2004PNAS..10115724W](https://ui.adsabs.harvard.edu/abs/2004PNAS..10115724W). [doi:10.1073/pnas.0404089101](https://doi.org/10.1073/pnas.0404089101). [PMC 524842](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524842). [PMID 15498874](https://pubmed.ncbi.nlm.nih.gov/15498874)
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Hillier LW; Fulton RS; Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". *Nature*. **424** (6945): 157–64. [Bibcode:2003Natur.424..157H](https://ui.adsabs.harvard.edu/abs/2003Natur.424..157H). [doi:10.1038/nature01782](https://doi.org/10.1038/nature01782). [PMID 12853948](https://pubmed.ncbi.nlm.nih.gov/12853948)
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". *Genome Res.*. **8** (11): 1097–108. [doi:10.1101/gr.8.11.1097](https://doi.org/10.1101/gr.8.11.1097). [PMID 9847074](https://pubmed.ncbi.nlm.nih.gov/9847074)

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Adapted from the Wikipedia article [ORAI2](https://en.wikipedia.org/wiki/ORAI2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ORAI2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.