# OPCML

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**Opioid-binding protein/cell adhesion molecule** is a [protein](/source/Protein) that in humans is encoded by the *OPCML* [gene](/source/Gene).[1][2]

This gene encodes a member of the IgLON subfamily in the [immunoglobulin](/source/Immunoglobulin) protein superfamily. The encoded protein is localized in the [cell membrane](/source/Cell_membrane) and may have an accessory role in [opioid](/source/Opioid) receptor function. This gene has an [ortholog](/source/Ortholog) in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid [alkaloids](/source/Alkaloids) in the presence of acidic [lipids](/source/Lipids), exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in [mammalian](/source/Mammalian) systems. Two transcript variants encoding different [isoforms](/source/Isoforms) have been found for this gene.[2]

## References

1. Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y (Dec 1993). "A sequence-tagged site map of human chromosome 11". *Genomics*. **17** (3): 699–725. [doi:10.1006/geno.1993.1392](https://doi.org/10.1006/geno.1993.1392). [PMID 8244387](https://pubmed.ncbi.nlm.nih.gov/8244387)

1. ["Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4978)

## Further reading

- Lane CM, Elde R, Loh HH, Lee NM (1993). "Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors". *Proc. Natl. Acad. Sci. U.S.A.*. **89** (23): 11234–8. [doi:10.1073/pnas.89.23.11234](https://doi.org/10.1073/pnas.89.23.11234). [PMC 50524](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50524). [PMID 1333602](https://pubmed.ncbi.nlm.nih.gov/1333602)
- Shark KB, Lee NM (1995). "Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM)". *Gene*. **155** (2): 213–7. [doi:10.1016/0378-1119(94)00830-L](https://doi.org/10.1016/0378-1119(94)00830-L). [PMID 7721093](https://pubmed.ncbi.nlm.nih.gov/7721093)
- Struyk AF, Canoll PD, Wolfgang MJ, etal (1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". *J. Neurosci.*. **15** (3 Pt 2): 2141–56. [doi:10.1523/JNEUROSCI.15-03-02141.1995](https://doi.org/10.1523/JNEUROSCI.15-03-02141.1995). [PMC 6578143](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578143). [PMID 7891157](https://pubmed.ncbi.nlm.nih.gov/7891157)
- Andersson B, Wentland MA, Ricafrente JY, etal (1996). "A "double adaptor" method for improved shotgun library construction". *Anal. Biochem.*. **236** (1): 107–13. [doi:10.1006/abio.1996.0138](https://doi.org/10.1006/abio.1996.0138). [PMID 8619474](https://pubmed.ncbi.nlm.nih.gov/8619474)
- Yu W, Andersson B, Worley KC, etal (1997). "Large-scale concatenation cDNA sequencing". *Genome Res.*. **7** (4): 353–8. [doi:10.1101/gr.7.4.353](https://doi.org/10.1101/gr.7.4.353). [PMC 139146](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146). [PMID 9110174](https://pubmed.ncbi.nlm.nih.gov/9110174)
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Sellar GC, Watt KP, Rabiasz GJ, etal (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". *Nat. Genet.*. **34** (3): 337–43. [doi:10.1038/ng1183](https://doi.org/10.1038/ng1183). [PMID 12819783](https://pubmed.ncbi.nlm.nih.gov/12819783). [S2CID 24411276](https://api.semanticscholar.org/CorpusID:24411276)
- Ota T, Suzuki Y, Nishikawa T, etal (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Schmitt-Ulms G, Hansen K, Liu J, etal (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". *Nat. Biotechnol.*. **22** (6): 724–31. [doi:10.1038/nbt969](https://doi.org/10.1038/nbt969). [PMID 15146195](https://pubmed.ncbi.nlm.nih.gov/15146195). [S2CID 36630738](https://api.semanticscholar.org/CorpusID:36630738)
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Mei FC, Young TW, Liu J, Cheng X (2006). "RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells". *FASEB J.*. **20** (3): 497–9. [doi:10.1096/fj.05-4586fje](https://doi.org/10.1096/fj.05-4586fje). [PMID 16384911](https://pubmed.ncbi.nlm.nih.gov/16384911). [S2CID 24792515](https://api.semanticscholar.org/CorpusID:24792515)
- Wang L, Zhu JS, Song MQ, etal (2007). "Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray". *World J. Gastroenterol.*. **12** (43): 6949–54. [doi:10.3748/wjg.v12.i43.6949](https://doi.org/10.3748/wjg.v12.i43.6949). [PMC 4087337](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087337). [PMID 17109515](https://pubmed.ncbi.nlm.nih.gov/17109515)
- Czekierdowski A, Czekierdowska S, Szymanski M, etal (2007). "Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer". *Neuro Endocrinol. Lett.*. **27** (5): 609–13. [PMID 17159813](https://pubmed.ncbi.nlm.nih.gov/17159813)
- Reed JE, Dunn JR, du Plessis DG, etal (2007). "Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours". *Neuropathol. Appl. Neurobiol.*. **33** (1): 77–85. [doi:10.1111/j.1365-2990.2006.00786.x](https://doi.org/10.1111/j.1365-2990.2006.00786.x). [PMID 17239010](https://pubmed.ncbi.nlm.nih.gov/17239010). [S2CID 22479211](https://api.semanticscholar.org/CorpusID:22479211)

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Adapted from the Wikipedia article [OPCML](https://en.wikipedia.org/wiki/OPCML) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/OPCML?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.