# OLE RNA

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> Markdown URL: https://mediated.wiki/source/OLE_RNA.md
> Source: https://en.wikipedia.org/wiki/OLE_RNA
> Source revision: 1317487029
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{{Infobox rfam
| Name = Ornate Large Extremophilic RNA
| image = OLE_secondary_structure.jpg
| width = 
| caption = Predicted [secondary structure](/source/secondary_structure) and [sequence conservation](/source/sequence_conservation) of OLE
| Symbol = OLE
| AltSymbols = 
| Rfam = RF01071
| miRBase = 
| miRBase_family = 
| RNA_type = [Gene](/source/Gene)
| Tax_domain = [Bacteria](/source/Bacteria)
| GO = 
| SO = {{SO|0001263}} 
| CAS_number = 
| EntrezGene = 
| HGNCid = 
| OMIM = 
| PDB = https://www.rcsb.org/structure/7KKV
| RefSeq = 
| Chromosome = 
| Arm = 
| Band = 
| LocusSupplementaryData = 
}}

'''OLE RNA''' ('''Ornate Large Extremophilic RNA''') is a conserved [RNA](/source/RNA) structure present in certain [bacteria](/source/bacteria).<ref>{{cite journal |vauthors=Puerta-Fernandez E, Barrick JE, Roth A, Breaker RR |title=Identification of a large noncoding RNA in extremophilic eubacteria |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue=51 |pages=19490–19495 |date=December 2006 |pmid=17164334 |pmc=1748253 |doi=10.1073/pnas.0607493103 |bibcode=2006PNAS..10319490P |doi-access=free }}</ref>  The RNA averages roughly 610 [nucleotides](/source/nucleotides) in length.  The only known RNAs that are longer than OLE RNA are [ribozyme](/source/ribozyme)s such as the [group II intron](/source/group_II_intron) and [ribosomal RNA](/source/ribosomal_RNA)s.  The exceptional length and highly conserved structure of OLE RNA prompted the hypothesis that OLE RNA could be a ribozyme, or otherwise perform an intricate biochemical task.

OLE RNAs are predominantly found in the order [Clostridiales](/source/Clostridiales), but other kinds of [Bacillota](/source/Bacillota) contain OLE RNAs as well.  Organisms containing OLE RNA are predominantly [extremophile](/source/extremophile)s and [anaerobe](/source/anaerobe)s.

OLE RNAs are transcribed as RNA, and experiments in [Bacillus halodurans](/source/Bacillus_halodurans) show that it is transcribed in a [mRNA](/source/mRNA) with 10 other [gene](/source/gene)s.  The adjacent genes are conserved in the vicinity of OLE RNA in most species containing it, but in [Desulfitobacterium hafniense](/source/Desulfitobacterium_hafniense) they are located elsewhere on the [chromosome](/source/chromosome).  OLE RNAs are processed from the larger transcript into a shorter RNA that roughly corresponds to the conserved, ~610-nucleotide structure.  Genes encoding a protein class of unknown function are typically located immediately downstream of OLE RNAs, and the presence of this protein class is correlated in species with the presence of OLE RNA.  This correlation suggests a possible functional association between the RNA and the protein.

[X-ray](/source/X-ray_crystallography) structural studies revealed key elements that help specifically recognise the OapB protein in [Bacillus halodurans](/source/Bacillus_halodurans).<ref>{{Cite journal|last1=Yang|first1=Yang|last2=Harris|first2=Kimberly A.|last3=Widner|first3=Danielle L.|last4=Breaker|first4=Ronald R.|date=2021-03-02|title=Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex|journal=Proceedings of the National Academy of Sciences|language=en|volume=118|issue=9|article-number=e2020393118|doi=10.1073/pnas.2020393118|pmid=33619097|pmc=7936274|bibcode=2021PNAS..11820393Y |issn=0027-8424|doi-access=free}}</ref>

==References==
{{reflist}}

==External links==
* {{Rfam|id=RF01071|name=OLE_RNA}}

Category:Non-coding RNA

{{molecular-cell-biology-stub}}

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Adapted from the Wikipedia article [OLE RNA](https://en.wikipedia.org/wiki/OLE_RNA) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/OLE_RNA?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.