# Normalized chromosome value

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**Normalized chromosome value** (NCV) is a mathematical calculation for comparing each [chromosome](/source/Chromosome) under tested in [cell free DNA](/source/Cell-free_fetal_DNA) (cfDNA) for detecting genetic disorder of the fetus. NCV calculation removes variation within and between [sequencing](/source/Sequencing) runs to optimize test precision.[1][2]

## References

1. ["Clinical Data"](http://www.verinata.com/providers/clinical-data/). Verinata. 2012-01-11. Retrieved 2013-08-19.

1. Sehnert AJ, etal (Jul 2011). "Optimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood.". *Clin. Chem.*. **57** (7): 1042–9. [doi:10.1373/clinchem.2011.165910](https://doi.org/10.1373/clinchem.2011.165910). [PMID 21519036](https://pubmed.ncbi.nlm.nih.gov/21519036)

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