# Ninein

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Protein in humans and other animals

NIN Identifiers Aliases NIN, SCKL7, ninein External IDs OMIM: 608684; MGI: 105108; HomoloGene: 40632; GeneCards: NIN; OMA:NIN - orthologs Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 50,719,763 bp[1] End 50,831,162 bp[1] Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 70,058,209 bp[2] End 70,160,491 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cardiac muscle tissue of right atrium tendon of biceps brachii bone marrow cell blood sural nerve monocyte trabecular bone skin of hip internal globus pallidus Top expressed in secondary oocyte primary oocyte granulocyte zygote tail of embryo decidua gastrula olfactory epithelium morula morula More reference expression data BioGPS n/a Gene ontology Molecular function nucleotide binding calcium ion binding GTP binding protein binding kinase binding Cellular component cytoplasm microtubule organizing center spindle pole nucleolus pericentriolar material microtubule cytoskeleton mitotic spindle pole microtubule minus-end centrosome ciliary transition fiber nucleus centriole mitotic spindle centriolar subdistal appendage plasma membrane axon dendrite axonal growth cone apical part of cell Biological process centrosome localization centrosome-templated microtubule nucleation microtubule anchoring at centrosome protein localization centriole-centriole cohesion corpus callosum morphogenesis corticospinal tract morphogenesis positive regulation of microtubule polymerization collateral sprouting positive regulation of axonogenesis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 51199 18080 Ensembl ENSG00000100503 ENSMUSG00000021068 UniProt Q8N4C6 Q61043 RefSeq (mRNA) NM_016350 NM_020921 NM_182944 NM_182945 NM_182946 NM_001081453 NM_001286079 NM_001286080 NM_008697 RefSeq (protein) NP_057434 NP_065972 NP_891989 NP_891991 NP_001074922 NP_001273008 NP_001273009 NP_032723 NP_001390761 Location (UCSC) Chr 14: 50.72 – 50.83 Mb Chr 12: 70.06 – 70.16 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Ninein** is a [protein](/source/Protein) that in humans is encoded by the *NIN* [gene](/source/Gene).[5][6][7]

## Function

Ninein, together with its [paralog](/source/Paralog) [Ninein-like protein](/source/NINL) is one of the proteins important for [centrosomal](/source/Centrosome) function. Localization of this protein to the centrosome requires three [leucine zippers](/source/Leucine_zipper) in the central [coiled-coil](/source/Coiled-coil) domain. Multiple [alternatively spliced](/source/Alternative_splicing) transcript variants that encode different [isoforms](/source/Isoform) have been reported.[7]

This protein is important for positioning and anchoring the [microtubules](/source/Microtubule) minus-ends in [epithelial cells](/source/Epithelial_cell).[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000100503](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000100503) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000021068](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000021068) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=51199). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=18080). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11004522_5-0)** Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". *Biochim Biophys Acta*. **1492** (2–3): 513–6. [doi](/source/Doi_(identifier)):[10.1016/S0167-4781(00)00127-5](https://doi.org/10.1016%2FS0167-4781%2800%2900127-5). [PMID](/source/PMID_(identifier)) [11004522](https://pubmed.ncbi.nlm.nih.gov/11004522).

1. **[^](#cite_ref-pmid11162463_6-0)** Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". *Biochem. Biophys. Res. Commun*. **279** (3): 989–95. [doi](/source/Doi_(identifier)):[10.1006/bbrc.2000.4050](https://doi.org/10.1006%2Fbbrc.2000.4050). [PMID](/source/PMID_(identifier)) [11162463](https://pubmed.ncbi.nlm.nih.gov/11162463).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) [***c***](#cite_ref-entrez_7-2) ["Entrez Gene: NIN ninein (GSK3B interacting protein)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51199).

## Further reading

- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). ["Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones"](https://doi.org/10.1093%2Fdnares%2F9.3.99). *DNA Res*. **9** (3): 99–106. [doi](/source/Doi_(identifier)):[10.1093/dnares/9.3.99](https://doi.org/10.1093%2Fdnares%2F9.3.99). [PMID](/source/PMID_(identifier)) [12168954](https://pubmed.ncbi.nlm.nih.gov/12168954).

- Bonaldo MF, Lennon G, Soares MB (1997). ["Normalization and subtraction: two approaches to facilitate gene discovery"](https://doi.org/10.1101%2Fgr.6.9.791). *Genome Res*. **6** (9): 791–806. [doi](/source/Doi_(identifier)):[10.1101/gr.6.9.791](https://doi.org/10.1101%2Fgr.6.9.791). [PMID](/source/PMID_(identifier)) [8889548](https://pubmed.ncbi.nlm.nih.gov/8889548).

- Mack GJ, Rees J, Sandblom O, et al. (1998). ["Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome"](https://doi.org/10.1002%2F1529-0131%28199803%2941%3A3%3C551%3A%3AAID-ART22%3E3.0.CO%3B2-X). *Arthritis Rheum*. **41** (3): 551–8. [doi](/source/Doi_(identifier)):[10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X](https://doi.org/10.1002%2F1529-0131%28199803%2941%3A3%3C551%3A%3AAID-ART22%3E3.0.CO%3B2-X). [PMID](/source/PMID_(identifier)) [9506584](https://pubmed.ncbi.nlm.nih.gov/9506584).

- Nagase T, Kikuno R, Nakayama M, et al. (2001). ["Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"](https://doi.org/10.1093%2Fdnares%2F7.4.271). *DNA Res*. **7** (4): 273–81. [doi](/source/Doi_(identifier)):[10.1093/dnares/7.4.271](https://doi.org/10.1093%2Fdnares%2F7.4.271). [PMID](/source/PMID_(identifier)) [10997877](https://pubmed.ncbi.nlm.nih.gov/10997877).

- Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". *J. Cell Sci*. **115** (Pt 9): 1825–35. [doi](/source/Doi_(identifier)):[10.1242/jcs.115.9.1825](https://doi.org/10.1242%2Fjcs.115.9.1825). [PMID](/source/PMID_(identifier)) [11956314](https://pubmed.ncbi.nlm.nih.gov/11956314).

- Dammermann A, Merdes A (2002). ["Assembly of centrosomal proteins and microtubule organization depends on PCM-1"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173044). *J. Cell Biol*. **159** (2): 255–66. [doi](/source/Doi_(identifier)):[10.1083/jcb.200204023](https://doi.org/10.1083%2Fjcb.200204023). [PMC](/source/PMC_(identifier)) [2173044](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173044). [PMID](/source/PMID_(identifier)) [12403812](https://pubmed.ncbi.nlm.nih.gov/12403812).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Chen CH, Howng SL, Cheng TS, et al. (2003). "Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle". *Biochem. Biophys. Res. Commun*. **308** (4): 975–83. [doi](/source/Doi_(identifier)):[10.1016/S0006-291X(03)01510-9](https://doi.org/10.1016%2FS0006-291X%2803%2901510-9). [PMID](/source/PMID_(identifier)) [12927815](https://pubmed.ncbi.nlm.nih.gov/12927815).

- Fritzler MJ, Zhang M, Stinton LM, Rattner JB (2004). ["Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC222907). *BMC Pediatrics*. **3**: 11. [doi](/source/Doi_(identifier)):[10.1186/1471-2431-3-11](https://doi.org/10.1186%2F1471-2431-3-11). [PMC](/source/PMC_(identifier)) [222907](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC222907). [PMID](/source/PMID_(identifier)) [14503922](https://pubmed.ncbi.nlm.nih.gov/14503922).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". *Nat. Cell Biol*. **6** (4): 319–27. [doi](/source/Doi_(identifier)):[10.1038/ncb1105](https://doi.org/10.1038%2Fncb1105). [PMID](/source/PMID_(identifier)) [15048123](https://pubmed.ncbi.nlm.nih.gov/15048123). [S2CID](/source/S2CID_(identifier)) [22767022](https://api.semanticscholar.org/CorpusID:22767022).

- Vizmanos JL, Novo FJ, Román JP, et al. (2004). ["NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder"](https://doi.org/10.1158%2F0008-5472.CAN-04-0144). *Cancer Res*. **64** (8): 2673–6. [doi](/source/Doi_(identifier)):[10.1158/0008-5472.CAN-04-0144](https://doi.org/10.1158%2F0008-5472.CAN-04-0144). [PMID](/source/PMID_(identifier)) [15087377](https://pubmed.ncbi.nlm.nih.gov/15087377).

- Howng SL, Hsu HC, Cheng TS, et al. (2004). ["A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors"](https://doi.org/10.1016%2Fj.febslet.2004.04.024). *FEBS Lett*. **566** (1–3): 162–8. [doi](/source/Doi_(identifier)):[10.1016/j.febslet.2004.04.024](https://doi.org/10.1016%2Fj.febslet.2004.04.024). [PMID](/source/PMID_(identifier)) [15147888](https://pubmed.ncbi.nlm.nih.gov/15147888).

- Stillwell EE, Zhou J, Joshi HC (2006). ["Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation"](https://doi.org/10.4161%2Fcc.3.7.947). *Cell Cycle*. **3** (7): 923–30. [doi](/source/Doi_(identifier)):[10.4161/cc.3.7.947](https://doi.org/10.4161%2Fcc.3.7.947). [PMID](/source/PMID_(identifier)) [15190203](https://pubmed.ncbi.nlm.nih.gov/15190203).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Delgehyr N, Sillibourne J, Bornens M (2005). ["Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function"](https://doi.org/10.1242%2Fjcs.02302). *J. Cell Sci*. **118** (Pt 8): 1565–75. [doi](/source/Doi_(identifier)):[10.1242/jcs.02302](https://doi.org/10.1242%2Fjcs.02302). [PMID](/source/PMID_(identifier)) [15784680](https://pubmed.ncbi.nlm.nih.gov/15784680).

- Cheng TS, Chang LK, Howng SL, et al. (2006). ["SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization"](http://ntur.lib.ntu.edu.tw//handle/246246/196401). *Life Sci*. **78** (10): 1114–20. [doi](/source/Doi_(identifier)):[10.1016/j.lfs.2005.06.021](https://doi.org/10.1016%2Fj.lfs.2005.06.021). [PMID](/source/PMID_(identifier)) [16154161](https://pubmed.ncbi.nlm.nih.gov/16154161).

v t e The centrosome and its components Centrioles SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1 Pericentriolar material BBS4 LCK PCM1 PCNT TNKS TNKS2 TUBE1 other proteins CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

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