# NLRP8

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**NLRP8**, short for [NOD-like receptor](/source/NOD-like_receptor) family [pyrin domain](/source/Pyrin_domain) containing 8, is an [intracellular](/source/Intracellular) protein that is expressed in the [ovaries](/source/Ovary), [testes](/source/Testes), and pre[implantation](/source/Implantation_(human_embryo)) [embryos](/source/Embryo) of mammals.[1][2] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of [cytoplasmic](/source/Cytoplasm) receptors.

## References

1. Ponsuksili S, Brunner RM, Goldammer T, etal (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". *Biol. Reprod.*. **74** (3): 577–84. [doi:10.1095/biolreprod.105.045096](https://doi.org/10.1095/biolreprod.105.045096). [PMID 16339045](https://pubmed.ncbi.nlm.nih.gov/16339045). [S2CID 2784688](https://api.semanticscholar.org/CorpusID:2784688)

1. Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". *BMC Evol. Biol.*. **9** (1). [Bibcode:2009BMCEE...9..202T](https://ui.adsabs.harvard.edu/abs/2009BMCEE...9..202T). [doi:10.1186/1471-2148-9-202](https://doi.org/10.1186/1471-2148-9-202). [PMC 2735741](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735741). [PMID 19682372](https://pubmed.ncbi.nlm.nih.gov/19682372)

## Further reading

- Enjuanes A, Benavente Y, Bosch F, etal (2008). ["Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia."](https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Genetic_Variants_in_Apoptosis_and_Immunoregulation-Related_Genes_Are_Associated_with_Risk_of_Chronic_Lymphocytic_Leukemia/22376466/1/files/39821778.pdf). *Cancer Res.*. **68** (24): 10178–86. [doi:10.1158/0008-5472.CAN-08-2221](https://doi.org/10.1158/0008-5472.CAN-08-2221). [PMID 19074885](https://pubmed.ncbi.nlm.nih.gov/19074885)
- Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". *Nat. Rev. Immunol.*. **3** (5): 371–82. [doi:10.1038/nri1086](https://doi.org/10.1038/nri1086). [PMID 12766759](https://pubmed.ncbi.nlm.nih.gov/12766759). [S2CID 8088987](https://api.semanticscholar.org/CorpusID:8088987)
- Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". *Nat. Rev. Mol. Cell Biol.*. **4** (2): 95–104. [doi:10.1038/nrm1019](https://doi.org/10.1038/nrm1019). [PMID 12563287](https://pubmed.ncbi.nlm.nih.gov/12563287). [S2CID 31417018](https://api.semanticscholar.org/CorpusID:31417018)

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