# NLRP4

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**NACHT, LRR and PYD domains-containing protein 4** is a [protein](/source/Protein) that in humans is encoded by the *NLRP4* [gene](/source/Gene).[1][2][3]

NALPs are [cytoplasmic](/source/Cytoplasm) proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an [N-terminal](/source/N-terminus) pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a [C-terminal](/source/C-terminus) leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a [caspase recruitment domain](/source/Caspase_recruitment_domain) (CARD). NALPs are implicated in the activation of [proinflammatory](/source/Proinflammatory) caspases (e.g., [CASP1](/source/CASP1); MIM 147678) via their involvement in multiprotein complexes called [inflammasomes](/source/Inflammasome) (Tschopp et al., 2003).[supplied by OMIM][3]

## References

1. Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". *Nat Rev Mol Cell Biol*. **4** (2): 95–104. [doi:10.1038/nrm1019](https://doi.org/10.1038/nrm1019). [PMID 12563287](https://pubmed.ncbi.nlm.nih.gov/12563287). [S2CID 31417018](https://api.semanticscholar.org/CorpusID:31417018)

1. Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". *J Biol Chem*. **277** (33): 29874–80. [doi:10.1074/jbc.M203915200](https://doi.org/10.1074/jbc.M203915200). [PMID 12019269](https://pubmed.ncbi.nlm.nih.gov/12019269)

1. ["Entrez Gene: NLRP4 NLR family, pyrin domain containing 4"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=147945)

## Further reading

- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". *Biochem. J.*. **381** (Pt 1): 213–9. [doi:10.1042/BJ20031506](https://doi.org/10.1042/BJ20031506). [PMC 1133779](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133779). [PMID 15107016](https://pubmed.ncbi.nlm.nih.gov/15107016)
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Grenier JM; Wang L; Manji GA et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". *FEBS Lett.*. **530** (1–3): 73–8. [Bibcode:2002FEBSL.530...73G](https://ui.adsabs.harvard.edu/abs/2002FEBSL.530...73G). [doi:10.1016/S0014-5793(02)03416-6](https://doi.org/10.1016/S0014-5793(02)03416-6). [PMID 12387869](https://pubmed.ncbi.nlm.nih.gov/12387869). [S2CID 25023390](https://api.semanticscholar.org/CorpusID:25023390)
- Fiorentino L; Stehlik C; Oliveira V et al. (2002). "A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta". *J. Biol. Chem.*. **277** (38): 35333–40. [doi:10.1074/jbc.M200446200](https://doi.org/10.1074/jbc.M200446200). [PMID 12093792](https://pubmed.ncbi.nlm.nih.gov/12093792)

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Adapted from the Wikipedia article [NLRP4](https://en.wikipedia.org/wiki/NLRP4) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/NLRP4?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.