# NLRP14

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**NLRP14**, short for [NOD-like receptor](/source/NOD-like_receptor) family [pyrin domain](/source/Pyrin_domain) containing 14, is an [intracellular](/source/Intracellular) protein of mammals associated with a role in [spermatogenesis](/source/Spermatogenesis). It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of [cytoplasmic](/source/Cytoplasm) receptors.[1] NLRP14 is found exclusively in the [testes](/source/Testes) where it is expressed within [spermatogonia](/source/Spermatogonia), [spermatocytes](/source/Spermatocyte) and [spermatids](/source/Spermatid).[2]

## References

1. Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". *Nat. Rev. Mol. Cell Biol.*. **4** (2): 95–104. [doi:10.1038/nrm1019](https://doi.org/10.1038/nrm1019). [PMID 12563287](https://pubmed.ncbi.nlm.nih.gov/12563287). [S2CID 31417018](https://api.semanticscholar.org/CorpusID:31417018)

1. Westerveld GH, Korver CM, van Pelt AM, etal (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". *Hum. Reprod.*. **21** (12): 3178–84. [doi:10.1093/humrep/del293](https://doi.org/10.1093/humrep/del293). [PMID 16931801](https://pubmed.ncbi.nlm.nih.gov/16931801)

## Further reading

- Enjuanes A, Benavente Y, Bosch F, etal (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". *Cancer Res.*. **68** (24): 10178–86. [doi:10.1158/0008-5472.CAN-08-2221](https://doi.org/10.1158/0008-5472.CAN-08-2221). [PMID 19074885](https://pubmed.ncbi.nlm.nih.gov/19074885)
- Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". *Nat. Rev. Immunol.*. **3** (5): 371–82. [doi:10.1038/nri1086](https://doi.org/10.1038/nri1086). [PMID 12766759](https://pubmed.ncbi.nlm.nih.gov/12766759). [S2CID 8088987](https://api.semanticscholar.org/CorpusID:8088987)
- Kimura K, Wakamatsu A, Suzuki Y, etal (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". *Genome Res.*. **16** (1): 55–65. [doi:10.1101/gr.4039406](https://doi.org/10.1101/gr.4039406). [PMC 1356129](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). [PMID 16344560](https://pubmed.ncbi.nlm.nih.gov/16344560)

## External links

- [PDBe-KB](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q86W24) provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)

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Adapted from the Wikipedia article [NLRP14](https://en.wikipedia.org/wiki/NLRP14) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/NLRP14?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.