# NFIL3

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Protein-coding gene in the species Homo sapiens

NFIL3 Identifiers Aliases NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated External IDs OMIM: 605327; MGI: 109495; HomoloGene: 3928; GeneCards: NFIL3; OMA:NFIL3 - orthologs Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 91,409,045 bp[1] End 91,423,832 bp[1] Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 27.68 cM Start 53,121,245 bp[2] End 53,135,109 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava pericardium gastric mucosa left uterine tube cartilage tissue popliteal artery tibial arteries stromal cell of endometrium periodontal fiber right ventricle Top expressed in muscle of thigh gastrula granulocyte zygote primary oocyte secondary oocyte digastric muscle left lobe of liver plantaris muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding transcription corepressor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding Cellular component nucleus Biological process cellular response to interleukin-4 positive regulation of gene expression regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II circadian rhythm immune response transcription, DNA-templated rhythmic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 4783 18030 Ensembl ENSG00000165030 ENSMUSG00000056749 UniProt Q16649 O08750 RefSeq (mRNA) NM_005384 NM_001289999 NM_001290000 NM_017373 RefSeq (protein) NP_001276928 NP_001276929 NP_005375 NP_059069 Location (UCSC) Chr 9: 91.41 – 91.42 Mb Chr 13: 53.12 – 53.14 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Nuclear factor, interleukin 3 regulated**, also known as **NFIL3** or **E4BP4** is a [protein](/source/Protein) which in humans is encoded by the *NFIL3* [gene](/source/Gene).[5]

## Function

Expression of interleukin-3 ([IL-3](/source/Interleukin_3)) is restricted to activated [T cells](/source/T_cell), natural killer ([NK](/source/Natural_killer_cell)) cells, and [mast cell](/source/Mast_cell) lines. [Transcription initiation](/source/Transcription_(genetics)#Initiation) depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[5][6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000165030](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000165030) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000056749](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000056749) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=4783). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=18030). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-entrez_5-0) [***b***](#cite_ref-entrez_5-1) ["Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4783).

1. **[^](#cite_ref-pmid7565758_6-0)** Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). ["Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230857). *Molecular and Cellular Biology*. **15** (11): 6055–63. [doi](/source/Doi_(identifier)):[10.1128/mcb.15.11.6055](https://doi.org/10.1128%2Fmcb.15.11.6055). [PMC](/source/PMC_(identifier)) [230857](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230857). [PMID](/source/PMID_(identifier)) [7565758](https://pubmed.ncbi.nlm.nih.gov/7565758).

## Further reading

- Cowell IG, Skinner A, Hurst HC (July 1992). ["Transcriptional repression by a novel member of the bZIP family of transcription factors"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC364521). *Molecular and Cellular Biology*. **12** (7): 3070–7. [doi](/source/Doi_(identifier)):[10.1128/mcb.12.7.3070](https://doi.org/10.1128%2Fmcb.12.7.3070). [PMC](/source/PMC_(identifier)) [364521](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC364521). [PMID](/source/PMID_(identifier)) [1620116](https://pubmed.ncbi.nlm.nih.gov/1620116).

- Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). ["Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230857). *Molecular and Cellular Biology*. **15** (11): 6055–63. [doi](/source/Doi_(identifier)):[10.1128/mcb.15.11.6055](https://doi.org/10.1128%2Fmcb.15.11.6055). [PMC](/source/PMC_(identifier)) [230857](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230857). [PMID](/source/PMID_(identifier)) [7565758](https://pubmed.ncbi.nlm.nih.gov/7565758).

- Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". *Gene*. **146** (2): 199–207. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90293-3](https://doi.org/10.1016%2F0378-1119%2894%2990293-3). [PMID](/source/PMID_(identifier)) [8076819](https://pubmed.ncbi.nlm.nih.gov/8076819).

- Cowell IG, Hurst HC (September 1996). ["Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146135). *Nucleic Acids Research*. **24** (18): 3607–13. [doi](/source/Doi_(identifier)):[10.1093/nar/24.18.3607](https://doi.org/10.1093%2Fnar%2F24.18.3607). [PMC](/source/PMC_(identifier)) [146135](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146135). [PMID](/source/PMID_(identifier)) [8836190](https://pubmed.ncbi.nlm.nih.gov/8836190).

- Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT (March 1997). ["Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20136). *Proceedings of the National Academy of Sciences of the United States of America*. **94** (6): 2609–14. [Bibcode](/source/Bibcode_(identifier)):[1997PNAS...94.2609I](https://ui.adsabs.harvard.edu/abs/1997PNAS...94.2609I). [doi](/source/Doi_(identifier)):[10.1073/pnas.94.6.2609](https://doi.org/10.1073%2Fpnas.94.6.2609). [PMC](/source/PMC_(identifier)) [20136](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20136). [PMID](/source/PMID_(identifier)) [9122243](https://pubmed.ncbi.nlm.nih.gov/9122243).

- Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (June 2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis". *Human Genetics*. **106** (6): 594–6. [doi](/source/Doi_(identifier)):[10.1007/s004390000306](https://doi.org/10.1007%2Fs004390000306). [PMID](/source/PMID_(identifier)) [10942106](https://pubmed.ncbi.nlm.nih.gov/10942106).

- Ozkurt IC, Tetradis S (July 2003). ["Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts"](https://doi.org/10.1074%2Fjbc.M212652200). *The Journal of Biological Chemistry*. **278** (29): 26803–9. [doi](/source/Doi_(identifier)):[10.1074/jbc.M212652200](https://doi.org/10.1074%2Fjbc.M212652200). [PMID](/source/PMID_(identifier)) [12743120](https://pubmed.ncbi.nlm.nih.gov/12743120).

- Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD (June 2006). ["Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763529). *Biochemical and Biophysical Research Communications*. **344** (2): 491–9. [Bibcode](/source/Bibcode_(identifier)):[2006BBRC..344..491P](https://ui.adsabs.harvard.edu/abs/2006BBRC..344..491P). [doi](/source/Doi_(identifier)):[10.1016/j.bbrc.2006.03.169](https://doi.org/10.1016%2Fj.bbrc.2006.03.169). [PMC](/source/PMC_(identifier)) [2763529](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763529). [PMID](/source/PMID_(identifier)) [16630563](https://pubmed.ncbi.nlm.nih.gov/16630563).

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

v t e Transcription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B sMaf F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist Group B FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D DEC 1 2 BHLHA9 Pho4 ID 1 2 3 4 Group E HES 1 2 3 4 5 6 7 HEY 1 2 L Group F bHLH-COE EBF1 (1.3) bHLH-ZIP AP-4 MAX MXD1 MXD3 MITF MNT MLX MLXIPL MXI1 Myc SREBP 1 2 USF1 (1.4) NF-1 NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4) (1.5) RF-X RFX 1 2 3 4 5 6 ANK (1.6) Basic helix-span-helix (bHSH) AP-2 α β γ δ ε (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX subfamily 3 Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ subfamily 4 NUR NGFIB NOR1 NURR1 subfamily 5 LRH-1 SF1 subfamily 6 GCNF subfamily 0 DAX1 SHP (2.2) Other Cys4 GATA 1 2 3 4 5 6 MTA 1 2 3 TRPS1 (2.3) Cys2His2 General transcription factors TFIIA TFIIB TFIID TFIIE 1 2 TFIIF 1 2 TFIIH 1 2 4 2I 3A 3C1 3C2 ATBF1 BCL 6 11A 11B CTCF E4F1 EGR 1 2 3 4 ERV3 GFI1 GLI family 1 2 3 REST S1 S2 YY1 HIC 1 2 HIVEP 1 2 3 IKZF 1 2 3 ILF 2 3 Sp/KLF family KLF 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 SP 1 2 4 7 8 MTF1 MYT1 OSR1 PRDM9 SALL 1 2 3 4 TSHZ3 WT1 Zbtb7 7A 7B ZBTB 11 16 17 20 21 32 33 40 zinc finger 3 7 9 10 19 22 24 33B 34 35 41 43 44 51 74 143 146 148 165 202 217 219 238 239 259 267 268 281 300 318 330 346 350 365 366 384 423 451 452 471 593 638 644 649 655 804A (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE DIDO1 GRLF1 ING 1 2 4 JARID 1A 1B 1C 1D 2 JMJD1B (2.6) WRKY WRKY (3) Helix-turn-helix domains (3.1) Homeodomain Antennapedia ANTP class protoHOX Hox-like ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox: Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1 metaHOX NK-like BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF 1 3 6 8 10 16 17 20 21A POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 SATB2 ZEB 1 2 (3.2) Paired box PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 PROP1 PHOX 2A 2B RAX SHOX SHOX2 VSX1 VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5 D4L6 E1 E3 F1 F2 G1 H1 I1 I2 I3 J1 J2 J3 K1 K2 L1 L2 M1 N1 N2 N3 N4 O1 O3 O4 O6 P1 P2 P3 P4 Q1 R1 R2 S1 (3.4) Heat shock factors HSF 1 2 4 (3.5) Tryptophan clusters ELF 2 4 5 EHF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain transcriptional enhancer factor 1 2 3 4 (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5 (4.2) STAT STAT 1 2 3 4 5 6 (4.3) p53-like p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1 (0.3) Pocket domain Rb RBL1 RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 EREBP B3 (0.6) Miscellaneous ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma see also transcription factor/coregulator deficiencies

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Adapted from the Wikipedia article [NFIL3](https://en.wikipedia.org/wiki/NFIL3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/NFIL3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.