# NDRG4

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**Protein NDRG4** is a [protein](/source/Protein) that in humans is encoded by the *NDRG4* [gene](/source/Gene).[1][2][3]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta [hydrolase](/source/Hydrolase) superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of [mitogenic](/source/Mitogen) signalling in vascular [smooth muscles](/source/Smooth_muscles) cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]

## References

1. Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". *Genomics*. **73** (1): 86–97. [doi:10.1006/geno.2000.6496](https://doi.org/10.1006/geno.2000.6496). [PMID 11352569](https://pubmed.ncbi.nlm.nih.gov/11352569)

1. Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". *J Cell Biochem*. **98** (1): 185–93. [doi:10.1002/jcb.20763](https://doi.org/10.1002/jcb.20763). [PMID 16408304](https://pubmed.ncbi.nlm.nih.gov/16408304). [S2CID 10192022](https://api.semanticscholar.org/CorpusID:10192022)

1. ["Entrez Gene: NDRG4 NDRG family member 4"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=65009)

## Further reading

- Nakajima D; Okazaki N; Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". *DNA Res.*. **9** (3): 99–106. [doi:10.1093/dnares/9.3.99](https://doi.org/10.1093/dnares/9.3.99). [PMID 12168954](https://pubmed.ncbi.nlm.nih.gov/12168954)
- Andersson B; Wentland MA; Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". *Anal. Biochem.*. **236** (1): 107–13. [doi:10.1006/abio.1996.0138](https://doi.org/10.1006/abio.1996.0138). [PMID 8619474](https://pubmed.ncbi.nlm.nih.gov/8619474)
- Yu W; Andersson B; Worley KC et al. (1997). "Large-Scale Concatenation cDNA Sequencing". *Genome Res.*. **7** (4): 353–8. [doi:10.1101/gr.7.4.353](https://doi.org/10.1101/gr.7.4.353). [PMC 139146](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146). [PMID 9110174](https://pubmed.ncbi.nlm.nih.gov/9110174)
- Hirosawa M; Nagase T; Ishikawa K et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". *DNA Res.*. **6** (5): 329–36. [doi:10.1093/dnares/6.5.329](https://doi.org/10.1093/dnares/6.5.329). [PMID 10574461](https://pubmed.ncbi.nlm.nih.gov/10574461)
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". *Genome Res.*. **10** (11): 1788–95. [doi:10.1101/gr.143000](https://doi.org/10.1101/gr.143000). [PMC 310948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948). [PMID 11076863](https://pubmed.ncbi.nlm.nih.gov/11076863)
- Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". *Genome Res.*. **11** (3): 422–35. [doi:10.1101/gr.GR1547R](https://doi.org/10.1101/gr.GR1547R). [PMC 311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID 11230166](https://pubmed.ncbi.nlm.nih.gov/11230166)
- Qu X; Zhai Y; Wei H et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". *Mol. Cell. Biochem.*. **229** (1–2): 35–44. [doi:10.1023/A:1017934810825](https://doi.org/10.1023/A:1017934810825). [PMID 11936845](https://pubmed.ncbi.nlm.nih.gov/11936845). [S2CID 24226208](https://api.semanticscholar.org/CorpusID:24226208)
- Ohki T; Hongo S; Nakada N et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". *Brain Res. Dev. Brain Res.*. **135** (1–2): 55–63. [doi:10.1016/S0165-3806(02)00300-0](https://doi.org/10.1016/S0165-3806(02)00300-0). [PMID 11978393](https://pubmed.ncbi.nlm.nih.gov/11978393)
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Nishimoto S; Tawara J; Toyoda H et al. (2003). "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells". *Eur. J. Biochem.*. **270** (11): 2521–31. [doi:10.1046/j.1432-1033.2003.03626.x](https://doi.org/10.1046/j.1432-1033.2003.03626.x). [PMID 12755708](https://pubmed.ncbi.nlm.nih.gov/12755708)
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". *Genome Res.*. **14** (10B): 2136–44. [doi:10.1101/gr.2576704](https://doi.org/10.1101/gr.2576704). [PMC 528930](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930). [PMID 15489336](https://pubmed.ncbi.nlm.nih.gov/15489336)
- Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". *Nucleic Acids Res.*. **34** (Database issue): D415–8. [doi:10.1093/nar/gkj139](https://doi.org/10.1093/nar/gkj139). [PMC 1347501](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501). [PMID 16381901](https://pubmed.ncbi.nlm.nih.gov/16381901)

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