# NCAPG2

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Protein-coding gene in the species Homo sapiens

NCAPG2 Identifiers Aliases NCAPG2, CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2, non-SMC condensin II complex subunit G2, 3KS External IDs OMIM: 608532; MGI: 1923294; HomoloGene: 9820; GeneCards: NCAPG2; OMA:NCAPG2 - orthologs Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 158,631,169 bp[1] End 158,704,804 bp[1] Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F2 Start 116,369,022 bp[2] End 116,427,351 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone secondary oocyte sperm ganglionic eminence bone marrow bone marrow cell trabecular bone stromal cell of endometrium gonad right testis Top expressed in nasal epithelium olfactory epithelium secondary oocyte primary oocyte zygote ventricular zone fetal liver hematopoietic progenitor cell tail of embryo dermis superior cervical ganglion More reference expression data BioGPS More reference expression data Gene ontology Molecular function methylated histone binding protein binding bHLH transcription factor binding molecular function regulator Cellular component membrane nucleus nucleoplasm condensin complex nuclear speck Biological process cell division cell cycle chromosome condensation inner cell mass cell proliferation transcription by RNA polymerase II erythrocyte differentiation negative regulation of erythrocyte differentiation positive regulation of protein tyrosine kinase activity positive regulation of signaling receptor activity Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 54892 76044 Ensembl ENSG00000146918 ENSMUSG00000042029 UniProt Q86XI2 Q6DFV1 RefSeq (mRNA) NM_001281932 NM_001281933 NM_017760 NM_133762 RefSeq (protein) NP_001268861 NP_001268862 NP_060230 NP_598523 Location (UCSC) Chr 7: 158.63 – 158.7 Mb Chr 12: 116.37 – 116.43 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Condensin-2 complex subunit G2** (CAP-G2) also known as **chromosome-associated protein G2** (CAP-G2) or **leucine zipper protein 5** (LUZP5) is a [protein](/source/Protein) that in humans is encoded by the *NCAPG2* [gene](/source/Gene).[5][6] CAP-G2 is a subunit of [condensin](/source/Condensin) II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis[7]

## Clinical importance

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, [failure to thrive](/source/Failure_to_thrive), ocular abnormalities, and defects in urogenital and limb morphogenesis.[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000146918](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000146918) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000042029](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000042029) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=54892). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=76044). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid14532007_5-0)** Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T (October 2003). ["Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells"](https://doi.org/10.1016%2FS0092-8674%2803%2900724-4). *Cell*. **115** (1): 109–21. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(03)00724-4](https://doi.org/10.1016%2FS0092-8674%2803%2900724-4). [PMID](/source/PMID_(identifier)) [14532007](https://pubmed.ncbi.nlm.nih.gov/14532007). [S2CID](/source/S2CID_(identifier)) [18811084](https://api.semanticscholar.org/CorpusID:18811084).

1. **[^](#cite_ref-entrez_6-0)** ["Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54892).

1. **[^](#cite_ref-7)** Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT (August 2014). ["The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores"](https://doi.org/10.1038%2Fncomms5588). *Nature Communications*. **5**: 4588. [Bibcode](/source/Bibcode_(identifier)):[2014NatCo...5.4588K](https://ui.adsabs.harvard.edu/abs/2014NatCo...5.4588K). [doi](/source/Doi_(identifier)):[10.1038/ncomms5588](https://doi.org/10.1038%2Fncomms5588). [PMID](/source/PMID_(identifier)) [25109385](https://pubmed.ncbi.nlm.nih.gov/25109385).

1. **[^](#cite_ref-Khan2019_8-0)** Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N, et al. (Task Force for Neonatal Genomics) (January 2019). ["Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323578). *American Journal of Human Genetics*. **104** (1): 94–111. [doi](/source/Doi_(identifier)):[10.1016/j.ajhg.2018.11.017](https://doi.org/10.1016%2Fj.ajhg.2018.11.017). [PMC](/source/PMC_(identifier)) [6323578](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323578). [PMID](/source/PMID_(identifier)) [30609410](https://pubmed.ncbi.nlm.nih.gov/30609410).

## Further reading

- Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD (February 2004). ["More than blood, a novel gene required for mammalian postimplantation development"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321451). *Molecular and Cellular Biology*. **24** (3): 1168–73. [doi](/source/Doi_(identifier)):[10.1128/MCB.24.3.1168-1173.2004](https://doi.org/10.1128%2FMCB.24.3.1168-1173.2004). [PMC](/source/PMC_(identifier)) [321451](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321451). [PMID](/source/PMID_(identifier)) [14729962](https://pubmed.ncbi.nlm.nih.gov/14729962).

- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). ["Phosphoproteome analysis of the human mitotic spindle"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365). *Proceedings of the National Academy of Sciences of the United States of America*. **103** (14): 5391–6. [Bibcode](/source/Bibcode_(identifier)):[2006PNAS..103.5391N](https://ui.adsabs.harvard.edu/abs/2006PNAS..103.5391N). [doi](/source/Doi_(identifier)):[10.1073/pnas.0507066103](https://doi.org/10.1073%2Fpnas.0507066103). [PMC](/source/PMC_(identifier)) [1459365](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365). [PMID](/source/PMID_(identifier)) [16565220](https://pubmed.ncbi.nlm.nih.gov/16565220).

v t e Structures of the cell nucleus / nuclear protein Envelope (membrane)/ nuclear lamina Pore complex: Nucleoporin NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 AAAS Nucleolus Cajal (coiled) body SMN GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 DDX20 COIL Perinucleolar compartment PTBP1 CUGBP1 TCOF ATXN7 Other Chromatin Dot (PML body) Paraspeckle SMC protein: Cohesin SMC1A SMC1B SMC3 Condensin NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 SMC2 SMC4 DNA repair SMC5 SMC6 Transition nuclear protein: TNP1 TNP2 Nuclear matrix (Nucleoskeleton) Nucleoplasm (Nucleosol) LITAF see also transcription factors and intracellular receptors see also nucleus diseases

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