# NBPF10

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**Neuroblastoma breakpoint family member 10** is a [protein](/source/Protein) that in *[Homo sapiens](/source/Homo_sapiens)* is encoded by the *NBPF10* [gene](/source/Gene).[1][2]

The full gene is 75,313 bp, with the major isoform of [mRNA](/source/MRNA) being 10,697 bp long. The gene is located at 1q21.1. NBPF contains what is known as the [DUF1220](/source/DUF1220) repeats. The highly conserved, repeated region is believed to be originated from [MGC8902](/source/MGC8902). The NBPF family has been linked to primate evolution.[2] It is assumed to be related to the [1q21.1 deletion syndrome](/source/1q21.1_deletion_syndrome) and [1q21.1 duplication syndrome](/source/1q21.1_duplication_syndrome).[3]

## Homology

Paralogs of NBPF10 includes other NBPF family members. Orthologs of NBPF10 are found in other primates; distant orthologs are found in bovine, equine, and canine

## Functional role

Although NBPF10's function is unknown, there is reason to believe that NBPF10 is an important [biomarker](/source/Biomarker) for the [Odontoblast](/source/Odontoblast) [Phenotype](/source/Phenotype)[4]

## Gene Neighborhood

[NOTCH2NL](/source/NOTCH2NL), [SEC22B](/source/SEC22B), [HFE2](/source/Hemojuvelin), [TXNIP](/source/TXNIP) are close neighbors of NBPF10. All of these neighboring genes are well studied in their own right.

## Post-translational modification

NBPF10 has extremely low [threonine](/source/Threonine) content which may make the protein less susceptible to [post-translational modification](/source/Post-translational_modification).[citation needed]

## References

1. ["Entrez Gene: NBPF10 neuroblastoma breakpoint family, member 10"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&DbFrom=protein&Cmd=Link&LinkName=protein_gene&IdsFromResult=291621653). Retrieved 28 April 2010.

1. Vandepoele K, Van Roy N, Staes K, Speleman F, van Roy F (November 2005). ["A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution"](https://biblio.ugent.be/publication/322748/file/6790117). *Mol. Biol. Evol.*. **22** (11): 2265–74. [doi:10.1093/molbev/msi222](https://doi.org/10.1093/molbev/msi222). [PMID 16079250](https://pubmed.ncbi.nlm.nih.gov/16079250)

1. Dumas, L. & Sikela, J. M. (2009-01-01). "DUF1220 Domains, Cognitive Disease, and Human Brain Evolution". *Cold Spring Harbor Symposia on Quantitative Biology*. **74**: 375–382. Cold Spring Harbor Laboratory. [doi:10.1101/sqb.2009.74.025](https://doi.org/10.1101/sqb.2009.74.025). [ISSN 0091-7451](https://www.worldcat.org/issn/0091-7451). [PMC 2902282](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902282). [PMID 19850849](https://pubmed.ncbi.nlm.nih.gov/19850849)

1. Butler W.T. & Ritchie H. (February 1995). "The nature and functional significance of dentin extracellular matrix proteins.". *Int J Dev Biol*. **39** (1): 169–79. [PMID 7626404](https://pubmed.ncbi.nlm.nih.gov/7626404)

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Adapted from the Wikipedia article [NBPF10](https://en.wikipedia.org/wiki/NBPF10) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/NBPF10?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.