# Mitosene

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> Source: https://en.wikipedia.org/wiki/Mitosene
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{{Short description|Class of organic chemicals}}
{{distinguish|mitosan}}
thumb|right|Chemical structure of mitosene
The '''mitosenes''' are a class of [organic chemical](/source/organic_chemical)s based on a [quinone](/source/quinone)-containing three-ring structure related to the two-ring core of the [indolequinone](/source/indolequinone)s. They are derived from the [mitomycins](/source/mitomycins) by [reduction](/source/organic_reduction) and are the active [alkylating](/source/alkylating) agents responsible for the [antitumor](/source/antitumor) activity of the mitomycins.<ref>{{cite journal |title= Mitosene–DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon Reductive Activation |last1= Maliepaard |first1= Marc |last2= de Mol |first2= Nico J. |last3= Tomasz |first3= Maria |last4= Gargiulo |first4= Dario |last5= Janssen |first5= Lambert H. M. |last6= van Duynhoven |first6= John P. M. |last7= van Velzen |first7= Ewoud J. J. |last8= Verboom |first8= Willem |last9= Reinhoudt |first9= David N. |journal= Biochemistry |year= 1997 |volume= 36 |issue= 30 |pages= 9211–9220 |doi= 10.1021/bi9700680 |pmid=9230054|url= https://research.utwente.nl/en/publications/mitosenedna-adducts-characterization-of-two-major-dna-monoadducts-formed-by-110bisacetoxy7methoxymitosene-upon-reductive-activation(32388144-99c3-43e4-9da3-b66abbd3df60).html |url-access= subscription }}</ref><ref>{{cite journal |title= A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes |first=1 Bhashyam S. |last1= Iyengar |first2= William A. |last2= Remers |journal= J. Med. Chem. |year= 1985 |volume= 28 |issue= 7 |pages= 963–967 |doi= 10.1021/jm00145a021 |pmid=3925148 }}</ref>

== References ==
{{reflist}}

Category:Quinones
Category:DNA replication inhibitors
Category:Enones

{{Carbohydrate-stub}}

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Adapted from the Wikipedia article [Mitosene](https://en.wikipedia.org/wiki/Mitosene) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Mitosene?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.