# Microviscosity

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Describing the thickness of fluid in a cell membrane

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**Microviscosity**, also known as **microscopic viscosity**, is the friction experienced by a single particle undergoing diffusion because of its interaction with its environment at the micrometer length scale. The concept of microviscosity is intimately related to the concept of single particle diffusion and can be measured using [microrheology](/source/Microrheology).

Understanding microviscosity requires an understanding of [viscosity](/source/Viscosity) and [diffusion](/source/Diffusion) i.e. macroscopic viscosity and bulk diffusion and where their assumptions break down at the micro to nanometer scale where physicists are still trying to replace phenomenological laws with physical laws governing the behavior of single particle mobility.

In the field of [biophysics](/source/Biophysics), a typical microviscosity problem is understanding how a [biomolecule](/source/Biomolecule)'s mobility is hindered within a cellular compartment which will depend upon many factors such as the size, shape, charge, quantity and density of both the diffusing particle and all members of its environment.[1]

Microviscosity can be probed by measuring the [rotational correlation time](/source/Rotational_correlation_time) of a probe molecule using either fluorescence correlation spectroscopy or the linewidths of the probe's [electron spin resonance](/source/Electron_spin_resonance). The friction experienced by a single particle can be thought of as a microscopic viscosity (microviscosity) and should not necessarily agree with the bulk viscosity since it is a measure of the probe's local friction whereas bulk viscosity analogously would be the measure of an infinitely large probe. Both the crowding density and relative size of each co-solute in a mixture will contribute to the measured microviscosity as assessed by altered translational mobility.[2]

## References

1. **[^](#cite_ref-1)** Basak, Sujit; Sengupta, Sombuddha; Chattopadhyay, Krishnananda (2019-08-23). ["Understanding biochemical processes in the presence of sub-diffusive behavior of biomolecules in solution and living cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957588). *Biophysical Reviews*. **11** (6): 851–872. [doi](/source/Doi_(identifier)):[10.1007/s12551-019-00580-9](https://doi.org/10.1007%2Fs12551-019-00580-9). [ISSN](/source/ISSN_(identifier)) [1867-2450](https://search.worldcat.org/issn/1867-2450). [PMC](/source/PMC_(identifier)) [6957588](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957588). [PMID](/source/PMID_(identifier)) [31444739](https://pubmed.ncbi.nlm.nih.gov/31444739).

1. **[^](#cite_ref-2)** Goins, A.B., H. Sanabria, M. N. Waxham. 2008. Macromolecular crowding and size effects on probe microviscosity. Biophys. J. 95:5362-5373.

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