# Methylamide

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{{One source|date=November 2021}}
In [biochemistry](/source/biochemistry), an '''''N''-methylamide''' (NME) is a blocking group for the [C-terminus](/source/C-terminus) end of [peptide](/source/peptide)s.  When the [carboxyl](/source/carboxyl) group of the C-terminus is replaced with a methylamide, further elongation of the peptide chain is prevented.  C-Terminal modified peptides are also useful for the modulation of [structure-activity relationship](/source/structure-activity_relationship)s and for modifying [conformational](/source/Chemical_structure) properties of peptides.  ''N''-Methylamides can be prepared directly from solid phase resin-bound peptides.<ref name="Ajayaghosh1996">{{cite journal |author1=Ajayaghosh, A. |author2=Pillai, V. N. Rajasekharan | title = Photo-triggered selective C-terminal N-methylamidative cleavage of polyethylene glycol-bound peptides | journal = Tetrahedron Letters | year = 1996 | volume = 37 | issue = 35 | pages = 6421–6424 | doi = 10.1016/0040-4039(96)01363-9}}</ref>

==References==
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Category:Carboxamides

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Adapted from the Wikipedia article [Methylamide](https://en.wikipedia.org/wiki/Methylamide) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Methylamide?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.