# Methyl halide transferase > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Methyl_halide_transferase > Markdown URL: https://mediated.wiki/source/Methyl_halide_transferase.md > Source: https://en.wikipedia.org/wiki/Methyl_halide_transferase > Source revision: 1303837174 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Infobox enzyme | Name = Methyl halide transferase | EC_number = 2.1.1.165 | CAS_number = | GO_code = | image = | width = | caption = }} '''Methyl halide transferase''' ({{EC number|2.1.1.165}}, ''MCT'', '''methyl chloride transferase''', ''S-adenosyl-L-methionine:halide/bisulfide methyltransferase'', ''AtHOL1'', ''AtHOL2'', ''AtHOL3'', ''HMT'', ''S-adenosyl-L-methionine: halide ion methyltransferase'', ''SAM:halide ion methyltransferase'') is an [enzyme](/source/enzyme) with [systematic name](/source/List_of_enzymes) ''S-adenosylmethionine:iodide methyltransferase''.{{cite journal | title = Expression of ''Batis maritima'' methyl chloride transferase in ''Escherichia coli'' |author1 = Ni, X. |author2 =Hager, L.P. |journal = Proc. Natl. Acad. Sci. USA |date = 1999 |volume = 96 |pages = 3611–3615 |pmid = 10097085 | doi = 10.1073/pnas.96.7.3611 | issue = 7 | pmc = 22342|bibcode = 1999PNAS...96.3611N |doi-access = free }}{{cite journal | title = Biochemical characterization of chloromethane emission from the wood-rotting fungus ''Phellinus pomaceus'' |author1 = Saxena, D. |author2 =Aouad, S. |author3 =Attieh, J. |author4 =Saini, H.S. |journal = Appl. Environ. Microbiol. |date = 1998 |volume = 64 |pages = 2831–2835 |pmid = 9687437 | issue = 8 |doi = 10.1128/AEM.64.8.2831-2835.1998 | pmc = 106779|bibcode = 1998ApEnM..64.2831S }}{{cite journal | title = Purification and characterization of a novel methyltransferase responsible for biosynthesis of halomethanes and methanethiol in ''Brassica oleracea'' |author1 = Attieh, J.M. |author2 =Hanson, A.D. |author3 =Saini, H.S. |journal = J. Biol. Chem. |date = 1995 |volume = 270 |pages = 9250–9257 |pmid = 7721844 | doi = 10.1074/jbc.270.16.9250 | issue = 16|doi-access = free }}{{cite journal | title = Involvement of ''S''-adenosylmethionine-dependent halide/thiol methyltransferase (HTMT) in methyl halide emissions from agricultural plants: isolation and characterization of an HTMT-coding gene from ''Raphanus sativus'' (daikon radish) |author1 = Itoh, N. |author2 =Toda, H. |author3 =Matsuda, M. |author4 =Negishi, T. |author5 =Taniguchi, T. |author6 =Ohsawa, N. | journal = BMC Plant Biol. |date = 2009 |volume = 9 |issue = 1 |pages = 116 |pmid = 19723322 | doi = 10.1186/1471-2229-9-116 | pmc = 2752461 |bibcode = 2009BMCPB...9..116I |doi-access = free }}{{cite journal | title = Purification and characterization of a monohalomethane-producing enzyme ''S''-adenosyl-L-methionine: halide ion methyltransferase from a marine microalga, ''Pavlova pinguis'' |author1 = Ohsawa, N. |author2 =Tsujita, M. |author3 =Morikawa, S. |author4 =Itoh, N. |journal = Biosci. Biotechnol. Biochem. |date = 2001 |volume = 65 |pages = 2397–2404 |pmid = 11791711 | doi = 10.1271/bbb.65.2397 | issue = 11|doi-access = free }}{{cite journal | title = Characterization of three halide methyltransferases in ''Arabidopsis thaliana'' |author1 = Nagatoshi, Y. |author2 = Nakamura, T. |journal = Plant Biotechnol. |date = 2007 |volume = 24 |issue = 5 |pages = 503–506 |doi=10.5511/plantbiotechnology.24.503|bibcode = 2007PBiot..24..503N |doi-access = free }} This enzyme [catalyses](/source/catalysis) the following [chemical reaction](/source/chemical_reaction) : [''S''-adenosyl-L-methionine](/source/S-adenosyl-L-methionine) + [iodide](/source/iodide) \rightleftharpoons [''S''-adenosyl-L-homocysteine](/source/S-adenosyl-L-homocysteine) + [methyl iodide](/source/methyl_iodide) This enzyme contributes to the [methyl halide](/source/methyl_halide) emissions from ''[Arabidopsis thaliana](/source/Arabidopsis_thaliana)''. ==Chloride transfer== {{main|Chloromethane#Biogenesis}} The [salt marsh](/source/salt_marsh) plant ''Batis maritima'' contains the enzyme [methyl chloride transferase](/source/methyl_chloride_transferase) that catalyzes the synthesis of [chloromethane](/source/chloromethane) (CH3Cl) from S-adenosine-L-methionine and chloride.{{cite journal |author1 = Ni X, Hager LP | year = 1998 | title = cDNA Cloning of ''Batis maritima'' Methyl Chloride Transferase |author2 = Purification of the Enzyme | journal = Proc Natl Acad Sci USA | volume = 95 | pages = 12866–71 | doi = 10.1073/pnas.95.22.12866 | pmid = 9789006 | issue = 22 | pmc = 23635| doi-access = free }} This protein has been purified and expressed in ''[E. coli](/source/E._coli)'', and seems to be present in other organisms such as white rot fungi (''[Phellinus pomaceus](/source/Phellinus_pomaceus)''), red algae (''[Endocladia muricata](/source/Endocladia_muricata)''), and the ice plant (''[Mesembryanthemum crystallinum](/source/Mesembryanthemum_crystallinum)''), each of which is a known CH3Cl producer.{{cite journal |vauthors=Ni X, Hager LP | year = 1999 | title = Expression of ''Batis maritima'' Methyl Chloride Transferase in ''Escherichia coli'' | journal = Proc Natl Acad Sci USA | volume = 96 | pages = 3611–5 | doi = 10.1073/pnas.96.7.3611 | pmid = 10097085 | issue = 7 | pmc = 22342| bibcode = 1999PNAS...96.3611N | doi-access = free }} == References == {{reflist}} == External links == * {{MeshName|Methyl+halide+transferase}} {{One carbon transferases}} {{Enzymes}} {{Portal bar|Biology|border=no}} Category:EC 2.1.1 --- Adapted from the Wikipedia article [Methyl halide transferase](https://en.wikipedia.org/wiki/Methyl_halide_transferase) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Methyl_halide_transferase?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.