# Meprin A

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> Markdown URL: https://mediated.wiki/source/Meprin_A.md
> Source: https://en.wikipedia.org/wiki/Meprin_A
> Source revision: 1172353125
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{infobox enzyme
| Name       = Meprin A
| EC_number  = 3.4.24.18
| CAS_number = 148938-24-3
| GO_code    = 0017090
| image      =
| width      = 
| caption    =  
}}
{{Pfam_box
| Symbol = Meprin
| Name = Meprin A
| image = 
| width =
| caption = 
| InterPro= IPR008294
| SMART=
| PROSITE = 
| SCOP = 
| TCDB =
| OPM family=
| OPM protein=
| Pfam= 
| PDB=
| Membranome family= 537
}}
'''Meprin A''' ({{EC number|3.4.24.18}}, ''endopeptidase-2'', ''meprin-a'', ''meprin'', ''N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase'', ''PABA-peptide hydrolase'', ''PPH'') is an [enzyme](/source/enzyme) that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.<ref name="pmid18783725">{{cite journal | vauthors = Sterchi EE, Stöcker W, Bond JS | title = Meprins, membrane-bound and secreted astacin metalloproteinases | journal = Molecular Aspects of Medicine | volume = 29 | issue = 5 | pages = 309–28 | date = October 2008 | pmid = 18783725 | pmc = 2650038 | doi = 10.1016/j.mam.2008.08.002 }}</ref> This metalloprotease can be associated with inflammatory responses.<ref name="Prox_2015">{{cite journal | vauthors = Prox J, Arnold P, Becker-Pauly C | title = Meprin α and meprin β: procollagen proteinases in health and disease. | journal = Matrix Biology | date = May 2015 | volume = 44 | pages = 7–13 | doi = 10.1016/j.matbio.2015.01.010 | pmid = 25617491 | doi-access = free }}</ref> It can be found in the extracellular space where it can also form complex structures by joining its monomers together.<ref name="Prox_2015" />

Meprin A is a dimer composed of the products transcribed from the following two genes:

{|
|{{protein
| Name = [meprin A, alpha](/source/MEP1A)
| caption = 
| image = 
| width = 
| HGNCid = 7015
| Symbol = [MEP1A](/source/MEP1A)
| AltSymbols = 
| EntrezGene = 4224
| OMIM = 600388
| RefSeq = NM_005588
| UniProt = Q16819
| PDB = 
| ECnumber = 3.4.24.18
| Chromosome = 6
| Arm = p
| Band = 12
| LocusSupplementaryData = -p11
}}
|{{protein
| Name = [meprin A, beta](/source/MEP1B)
| caption = 
| image = 
| width = 
| HGNCid = 7020
| Symbol = [MEP1B](/source/MEP1B)
| AltSymbols = 
| EntrezGene = 4225
| OMIM = 600389
| RefSeq = NM_005925
| UniProt = Q16820
| PDB = 
| ECnumber = 3.4.24.18
| Chromosome = 18
| Arm = q
| Band = 12.2-12.3
| LocusSupplementaryData = 
}}
|}

== References ==
{{Reflist}}

{{Metalloendopeptidases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

Category:EC 3.4.24
Category:Single-pass transmembrane proteins

{{biochemistry-stub}}

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Adapted from the Wikipedia article [Meprin A](https://en.wikipedia.org/wiki/Meprin_A) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Meprin_A?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.