# MeRIPseq

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**MeRIPseq**[1] (or **MeRIP-seq**) stands for [methylated](/source/Methylated) [RNA immunoprecipitation](/source/RNA_immunoprecipitation) sequencing, which is a method for detection of post-transcriptional [RNA](/source/RNA) modifications, developed by Kate Meyer et al. while working in the laboratory of Sammie Jaffrey at Cornell University Graduate School of Medical Sciences. It is also called m6A-seq.[2]

A variation of the MerIP-seq method was coined by Benjamin Delatte and colleagues in 2016. This variant, called hMerIP-seq (hydroxymethylcytosine RNA immunoprecipitation), uses an antibody that specifically recognizes 5-hydroxymethylcytosine, a modified RNA base affecting *in vitro* translation and brain development in Drosophila.[3]

## References

1. **[^](#cite_ref-1)** Meyer, Kate D.; Saletore, Yogesh; Zumbo, Paul; Elemento, Olivier; Mason, Christopher E.; Jaffrey, Samie R. (31 May 2012). ["Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383396). *Cell*. **149** (7): 1635–1646. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2012.05.003](https://doi.org/10.1016%2Fj.cell.2012.05.003). [PMC](/source/PMC_(identifier)) [3383396](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383396). [PMID](/source/PMID_(identifier)) [22608085](https://pubmed.ncbi.nlm.nih.gov/22608085).

1. **[^](#cite_ref-2)** Dominissini, Dan; Moshitch-Moshkovitz, Sharon; Schwartz, Schraga; Salmon-Divon, Mali; Ungar, Lior; Osenberg, Sivan; Cesarkas, Karen; Jacob-Hirsch, Jasmine; Amariglio, Ninette; Kupiec, Martin; Sorek, Rotem; Rechavi, Gideon (28 April 2012). "Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq". *Nature*. **485** (7397): 201–206. [Bibcode](/source/Bibcode_(identifier)):[2012Natur.485..201D](https://ui.adsabs.harvard.edu/abs/2012Natur.485..201D). [doi](/source/Doi_(identifier)):[10.1038/nature11112](https://doi.org/10.1038%2Fnature11112). [PMID](/source/PMID_(identifier)) [22575960](https://pubmed.ncbi.nlm.nih.gov/22575960). [S2CID](/source/S2CID_(identifier)) [3517716](https://api.semanticscholar.org/CorpusID:3517716).

1. **[^](#cite_ref-3)** Delatte, Benjamin (2016). ["Transcriptome-wide distribution and function of RNA hydroxymethylcytosine"](https://doi.org/10.1126%2Fscience.aac5253). *Science*. **351** (6270): 282–285. [Bibcode](/source/Bibcode_(identifier)):[2016Sci...351..282D](https://ui.adsabs.harvard.edu/abs/2016Sci...351..282D). [doi](/source/Doi_(identifier)):[10.1126/science.aac5253](https://doi.org/10.1126%2Fscience.aac5253). [PMID](/source/PMID_(identifier)) [26816380](https://pubmed.ncbi.nlm.nih.gov/26816380).

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