# Matthew P. Scott

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Matt Scott Citizenship United States Alma mater Massachusetts Institute of Technology (BS, PhD) Known for Homeobox Spouse Margaret T. Fuller Awards Member of the National Academy of Sciences (1999)[1] Scientific career Fields Developmental biology Institutions Stanford University Carnegie Institution for Science University of Colorado Boulder Indiana University Doctoral advisor Mary Lou Pardue Notable students Sean B. Carroll Chris Q. Doe Eileen Furlong (postdoc)[2] Website profiles.stanford.edu/matthew-scott

**Matthew Peter Scott** is an American biologist who was the tenth president of the Carnegie Institution for Science.[3] While at [Stanford University](/source/Stanford_University), Scott studied how embryonic and later development is governed by proteins that control [gene](/source/Gene) activity and [cell signaling](/source/Cell_signaling) processes.[4][5] He co-discovered [homeobox](/source/Homeobox) genes in *[Drosophila melanogaster](/source/Drosophila_melanogaster)* working with Amy J. Weiner at [Indiana University](/source/Indiana_University).[6][7]

Among his laboratory's discoveries, he is recognized for the cloning of the [patched](/source/Patched) gene family and demonstration that a human homolog [PTCH1](/source/PTCH1) is a key [tumor suppressor](/source/Tumor_suppressor) gene for the [Hedgehog signaling pathway](/source/Hedgehog_signaling_pathway) as well as the causative gene for the [nevoid basal cell carcinoma syndrome](/source/Nevoid_basal_cell_carcinoma_syndrome), or [Gorlin syndrome](/source/Gorlin_syndrome).[8][9]

## Education

Scott completed a B.S. in 1975 and Ph.D. in biology in 1980, both at [Massachusetts Institute of Technology](/source/Massachusetts_Institute_of_Technology).[10]

## Career and research

Scott served on the faculty of the Department of Molecular, Cellular, and Developmental Biology at the [University of Colorado](/source/University_of_Colorado_at_Boulder) starting in 1983. He moved to [Stanford University](/source/Stanford_University) in 1990 to join the faculty of the Department of Developmental Biology and the Department of Genetics. From 2002-2007 he served as Chair of Bio-X, Stanford's interdisciplinary biosciences program.[11]

### Awards and honors

- 1983 - Helen Hay Whitney [postdoctoral fellowship](/source/Postdoc)

- 1985 - [Searle Scholar](/source/Searle_Scholar)[12]

- 2004 - [Conklin Medal](/source/Conklin_Medal), Society for Developmental Biology[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed)*]

- 1999 - Member, [United States National Academy of Sciences](/source/United_States_National_Academy_of_Sciences)[1]

- 2007 - Member, [National Institute of Medicine](/source/National_Institute_of_Medicine)[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed)*]

## Personal life

He is married to Stanford developmental geneticist [Margaret T. Fuller](/source/Margaret_T._Fuller).[*[when?](https://en.wikipedia.org/wiki/Wikipedia:Manual_of_Style/Dates_and_numbers#Chronological_items)*]

## References

1. ^ [***a***](#cite_ref-nas_1-0) [***b***](#cite_ref-nas_1-1) ["Matthew P. Scott"](http://www.nasonline.org/member-directory/members/2538526.html).

1. **[^](#cite_ref-furlong_2-0)** Furlong, Eileen E.M.; Profitt, David; Scott, Matthew P. (2001). "Automated sorting of live transgenic embryos". *Nature Biotechnology*. **19** (2): 153–156. [doi](/source/Doi_(identifier)):[10.1038/84422](https://doi.org/10.1038%2F84422). [ISSN](/source/ISSN_(identifier)) [1087-0156](https://search.worldcat.org/issn/1087-0156). [PMID](/source/PMID_(identifier)) [11175730](https://pubmed.ncbi.nlm.nih.gov/11175730). [S2CID](/source/S2CID_(identifier)) [14228050](https://api.semanticscholar.org/CorpusID:14228050).

1. **[^](#cite_ref-3)** ["Matthew P. Scott's Profile | Stanford Profiles"](https://profiles.stanford.edu/matthew-scott).

1. **[^](#cite_ref-ScottlabStanford_4-0)** ["Scott lab homepage at Stanford University"](https://web.archive.org/web/20081204010423/http://scottlab.stanford.edu/). Archived from [the original](http://scottlab.stanford.edu/) on 2008-12-04. Retrieved 2009-04-10.

1. **[^](#cite_ref-ScottHHMI_5-0)** ["HHMI Scientist Bio: Matthew P. Scott, Ph.D."](http://www.hhmi.org/research/investigators/scottm_bio.html) Retrieved 2009-04-10.

1. **[^](#cite_ref-6)** [Scott, M. P.](https://en.wikipedia.org/w/index.php?title=Matthew_P._Scott_and_A._Weiner&action=edit&redlink=1) (1984). ["Structural Relationships among Genes That Control Development: Sequence Homology between the Antennapedia, Ultrabithorax, and Fushi Tarazu Loci of Drosophila"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC345379). *Proceedings of the National Academy of Sciences*. **81** (13): 4115–4119. [Bibcode](/source/Bibcode_(identifier)):[1984PNAS...81.4115S](https://ui.adsabs.harvard.edu/abs/1984PNAS...81.4115S). [doi](/source/Doi_(identifier)):[10.1073/pnas.81.13.4115](https://doi.org/10.1073%2Fpnas.81.13.4115). [PMC](/source/PMC_(identifier)) [345379](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC345379). [PMID](/source/PMID_(identifier)) [6330741](https://pubmed.ncbi.nlm.nih.gov/6330741).

1. **[^](#cite_ref-7)** Laughon, A.; Scott, M. P. (1984). "Sequence of a Drosophila segmentation gene: Protein structure homology with DNA-binding proteins". *Nature*. **310** (5972): 25–31. [Bibcode](/source/Bibcode_(identifier)):[1984Natur.310...25L](https://ui.adsabs.harvard.edu/abs/1984Natur.310...25L). [doi](/source/Doi_(identifier)):[10.1038/310025a0](https://doi.org/10.1038%2F310025a0). [PMID](/source/PMID_(identifier)) [6330566](https://pubmed.ncbi.nlm.nih.gov/6330566). [S2CID](/source/S2CID_(identifier)) [4346123](https://api.semanticscholar.org/CorpusID:4346123).

1. **[^](#cite_ref-8)** Hooper, J. E.; Scott, M. P. (1989). "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning". *Cell*. **59** (4): 751–765. [doi](/source/Doi_(identifier)):[10.1016/0092-8674(89)90021-4](https://doi.org/10.1016%2F0092-8674%2889%2990021-4). [PMID](/source/PMID_(identifier)) [2582494](https://pubmed.ncbi.nlm.nih.gov/2582494). [S2CID](/source/S2CID_(identifier)) [16246437](https://api.semanticscholar.org/CorpusID:16246437).

1. **[^](#cite_ref-9)** Johnson, R. L.; Rothman, A. L.; Xie, J.; Goodrich, L. V.; Bare, J. W.; Bonifas, J. M.; Quinn, A. G.; Myers, R. M.; Cox, D. R.; Epstein, E. H. Jr.; Scott, M. P. (1996). "Human homolog of patched, a candidate gene for the basal cell nevus syndrome". *Science*. **272** (5268): 1668–1671. [Bibcode](/source/Bibcode_(identifier)):[1996Sci...272.1668J](https://ui.adsabs.harvard.edu/abs/1996Sci...272.1668J). [doi](/source/Doi_(identifier)):[10.1126/science.272.5268.1668](https://doi.org/10.1126%2Fscience.272.5268.1668). [PMID](/source/PMID_(identifier)) [8658145](https://pubmed.ncbi.nlm.nih.gov/8658145). [S2CID](/source/S2CID_(identifier)) [9160210](https://api.semanticscholar.org/CorpusID:9160210).

1. **[^](#cite_ref-10)** ["Matthew P. Scott's Profile | Stanford Profiles"](https://profiles.stanford.edu/matthew-scott). *profiles.stanford.edu*. Retrieved 2023-03-30.

1. **[^](#cite_ref-11)** ["Biography: Matthew Scott"](https://web.archive.org/web/20100620145903/https://www.cgm.northwestern.edu/cgm/Academics/Richard-A.-Scott-MD-Lecture-Series/Biography-Matthew-Scott). Center for Genetic Medicine, [Northwestern University](/source/Northwestern_University). Archived from [the original](http://www.cgm.northwestern.edu/cgm/Academics/Richard-A.-Scott-MD-Lecture-Series/Biography-Matthew-Scott) on 2010-06-20. Retrieved 2009-04-10.

1. **[^](#cite_ref-12)** ["Scholar Profile, Matthew P. Scott"](http://www.searlescholars.net/person/384). Searle Scholars program. Retrieved 2009-04-10.

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