# Marcin Hoffmann

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**Marcin Maciej Hoffmann** (born October 2, 1972) is a Polish [scientist](/source/Scientist) and [entrepreneur](/source/Entrepreneurship). He is a professor of chemistry at the Faculty of Chemistry of [Adam Mickiewicz University in Poznań](/source/Adam_Mickiewicz_University_in_Pozna%C5%84).

## Early years

Hoffmann was born in 1972 in [Godziesze Wielkie](/source/Godziesze_Wielkie), a small town near [Kalisz](/source/Kalisz). He attended No. 30 Primary School in Poznań and the [Karol Marcinkowski High School in Poznań](/source/Karol_Marcinkowski_High_School); at that time, he succeeded as a laureate of Polish Physics Olympiad and twice as a laureate of Polish Chemistry Olympiad. In 1996, he was awarded the [MSc](/source/Master_of_Science) in Chemistry title at the Faculty of Chemistry of [Adam Mickiewicz University in Poznań](/source/Adam_Mickiewicz_University_in_Pozna%C5%84); his [thesis](/source/Thesis) *Theoretical analysis of selected [(R,R)-tartaric acid](/source/Tartaric_acid) [derivatives](/source/Derivative_(chemistry))*, supervised by Jacek Rychlewski, was awarded the first prize in Faculty's Contest for the best MSc dissertation of that year. In 1997, he achieved MSc in Biotechnology at the [AMU](/source/Adam_Mickiewicz_University_in_Pozna%C5%84) Faculty of Biology for his thesis *Properties of [glycoproteins](/source/Glycoprotein) isolated from [Chelidonium majus](/source/Chelidonium_majus) [milky sap](/source/Sap)*, supervised by Anna Goździcka-Józefiak. During his MSc courses he won a number of various [scholarships](/source/Scholarship), including ones granted by the [Minister of National Education](/source/Ministry_of_National_Education_(Poland)).[1] and [the Stefan Batory Foundation](/source/Stefan_Batory_Foundation), he was also the President of Student Council at the [AMU](/source/Adam_Mickiewicz_University_in_Pozna%C5%84) Faculty of Chemistry.[2] In 2000, he defended his [PhD](/source/Doctor_of_Philosophy) thesis in chemistry, *Effects of [substitution](/source/Substituent) of [hydroxyl group](/source/Hydroxy_group) by [fluorine atom](/source/Fluorine) - [ab initio](/source/Ab_initio_quantum_chemistry_methods) and [DFT](/source/Density_functional_theory) studies*[3] (under the supervision of Rychlewski), rewarded with the first prize in annual Faculty's Contest for the best PhD dissertation. He also completed an [MBA](/source/Master_of_Business_Administration) degree, organized jointly by [Poznań Academy of Economics](/source/Pozna%C5%84_University_of_Economics_and_Business) and [Georgia State University in Atlanta](/source/Georgia_State_University) in 2000 (with Henryk Mruk as the tutor of his managerial project) and [postgraduate studies](/source/Postgraduate_education) in [computer science](/source/Computer_science) at the [AMU](/source/Adam_Mickiewicz_University_in_Pozna%C5%84) Faculty of Mathematics and Computer Science in 2004.[2]

## Academic career

Already during his [MSc course](/source/Master_of_Science), Hoffmann took an academic internship at the [University of Oxford](/source/University_of_Oxford) under Dr John M. Brown.[2] Upon receiving his [PhD degree](/source/Doctor_of_Philosophy), he was employed as [assistant professor](/source/Assistant_professor) at the [AMU](/source/Adam_Mickiewicz_University_in_Pozna%C5%84) Faculty of Chemistry; in 2001–2002, he worked as a [postdoctoral fellow](/source/Postdoctoral_researcher) at [Emory University in Atlanta](/source/Emory_University), where he conducted research under the supervision of [Keiji Morokuma](/source/Keiji_Morokuma),[2] a globally recognized expert in [quantum chemistry](/source/Quantum_chemistry).[4] As a young scientist, he was awarded a number of [scholarships](/source/Scholarship) by various institutions, such as the [Foundation for Polish Science](/source/Foundation_for_Polish_Science) and the Centre for Applied [Wave Mechanics](/source/Quantum_mechanics) (*Centre de Mécanique Ondulatoire Appliquée*).[2] He defended his [habilitation thesis](/source/Habilitation) *[Quantum-chemical calculations](/source/Computational_chemistry) in [molecular modelling](/source/Molecular_modelling) of selected systems of importance in [chemistry](/source/Chemistry), [biochemistry](/source/Biochemistry), and [medicine](/source/Medicine)*[5] in 2009 and became an [associate professor](/source/Associate_professor) two years later. On March 8, 2017, at the age of 44, he was conferred [the professor title](/source/Professor) by [Andrzej Duda](/source/Andrzej_Duda), [the President of the Republic of Poland](/source/President_of_Poland).[6]

### Scientific activity

Hoffmann's research focuses on the application of [computational methods of quantum chemistry](/source/Computational_chemistry) in the investigation of the [structure of molecules](/source/Molecular_geometry) and the [interactions between them](/source/Intermolecular_force), as well as [modelling](/source/Molecular_modelling) of [enzymatic reactions](/source/Enzyme_catalysis) along with [designing novel drugs](/source/Drug_design) and [chemical compounds](/source/Chemical_compound) of desirable [activity](/source/Biological_activity) with the use of [computational models](/source/Computational_model) built for this purpose. The results of his scientific research include:

- Determination of the effect of [substitution](/source/Substituent) of [hydroxyl group](/source/Hydroxy_group) by [fluorine atom](/source/Fluorine) in a series of compounds, including [(R,R)-tartaric acid](/source/Tartaric_acid) [derivatives](/source/Derivative_(chemistry)) and [D-glucose](/source/Glucose), on their [conformational freedom](/source/Conformational_isomerism).[7][8][9]
- Detailed [conformational analysis](/source/Conformational_isomerism) of multiple [(R,R)-tartaric acid](/source/Tartaric_acid) [derivatives](/source/Derivative_(chemistry)).[10][11][12][13]
- Detailed explanation of the [mechanism](/source/Reaction_mechanism) of [squalene epoxidase](/source/Squalene_monooxygenase) [inhibition](/source/Enzyme_inhibitor) by [terbinafine](/source/Terbinafine) and elucidation of a fully atomic three-dimensional model of this [protein](/source/Protein).[14]
- Investigation of double [proton](/source/Proton) transfer in the [lumichrome](/source/Lumichrome) [dimer](/source/Dimer_(chemistry))[15] and in [lumichrome](/source/Lumichrome)/[acetic acid](/source/Acetic_acid) system.[16]
- Detailed research on the influence of a wide range of [substituents](/source/Substituent) on [geometric](/source/Molecular_geometry) and [electronic structure](/source/Electronic_structure) of fluoro- and trifluoromethylbenzene [derivatives](/source/Derivative_(chemistry)).[17]
- Explanation of the mechanism of [azathioprine](/source/Azathioprine) [bioactivation](/source/Bioactivation) by [cysteine](/source/Cysteine) and [glutathione](/source/Glutathione) molecules.[18]
- Characterization of homo- and heterodinuclear [complexes](/source/Coordination_complex) of [Zn(II)](/source/Zinc) and [Ln(III)](/source/Lanthanide) [ions](/source/Ion) with a [tridentate](/source/Tridentate_ligand) [Schiff-base ligand](/source/Schiff_base).[19]
- Investigation of selected purine derivatives ([antimetabolites](/source/Antimetabolite)) membrane transport.[20]
- Determination of protein effects of the [O2 molecule](/source/Oxygen) binding to the [active site](/source/Active_site) of [methane monooxygenase](/source/Methane_monooxygenase).[21]
- Discovery of frequent occurrence of [palindromic sequences](/source/Palindromic_sequence) in protein molecules.[22]
- Evaluation of effectiveness of [Fe(0)](/source/Iron) [complexes](/source/Coordination_complex) with multivinylsilicone [ligands](/source/Ligand) in [hydrosilylation](/source/Hydrosilylation) and dehydrogenative silylation of [styrene](/source/Styrene) with [trisubstituted](/source/Substituent) [silanes](/source/Silanes) and hydrosiloxanes.[23]
- Discovery of a common [palindromic sequence](/source/Palindromic_sequence) (TCTCGCGAGA) in human [gene promoters](/source/Promoter_(genetics)).[24]
- [Conformational analysis](/source/Conformational_isomerism) of [fluvastatin](/source/Fluvastatin)[25] and [atorvastatin](/source/Atorvastatin)[26] along with elucidation of the mechanism of their [lactone](/source/Lactone)-[hydroxycarboxylic acid](/source/Hydroxycarboxylic_acid) interconversion in [acidic and alkaline](/source/PH) environment.
- Explanation of the mechanism of interaction between [SARS coronavirus](/source/SARS_coronavirus) [helicase](/source/Helicase)/[ATPase](/source/ATPase) and [ATP](/source/Adenosine_triphosphate) and design of potential [inhibitors](/source/Enzyme_inhibitor) of this enzyme.[27]
- Design of novel [leulcyl-tRNA synthetase](/source/Leucyl-tRNA_synthetase) inhibitors[28] based on self-made [aminoacyl-tRNA synthase](/source/Aminoacyl_tRNA_synthetase) inhibitor [database](/source/Database).[29]
- Identification of novel [pregnane X receptor](/source/Pregnane_X_receptor) [activators](/source/Activator_(genetics)).[30]
- Development of a self-made [computer program](/source/Computer_program) MM2QM, combining [docking](/source/Docking_(molecular)), [molecular dynamics](/source/Molecular_dynamics), [molecular mechanics](/source/Molecular_mechanics), and [quantum mechanics](/source/Quantum_mechanics).[31]
- Investigation of the mechanism of [telomerase](/source/Telomerase) [inhibition](/source/Enzyme_inhibitor) by *[Chelidonium majus](/source/Chelidonium_majus)* [isoquinoline](/source/Isoquinoline) [alkaloids](/source/Alkaloid) through stabilization of [telomeric](/source/Telomere) [G-quadruplex sequences](/source/G-quadruplex).[32]
- Elucidation of [geometry](/source/Molecular_geometry) of UO4− [ion](/source/Ion), formed upon [dissociation](/source/Dissociation_(chemistry)) of some [complex uranyl anions](/source/Uranyl#Complexes).[33]

These and other studies resulted in authorship and co-authorship of ca. 100 [publications](/source/Scientific_literature#Scientific_article) (101 according to [Google Scholar](/source/Google_Scholar)), including highly prestigious [scientific journals](/source/Scientific_journal), such as [Journal of the American Chemical Society](/source/Journal_of_the_American_Chemical_Society) and [Cancer Research](/source/Cancer_Research_(journal)). His papers are increasingly [cited](/source/Citation) year after year (totalling 960 - [Google Scholar](/source/Google_Scholar)), which yields 9,50 citations per publication and the [h-index](/source/H-index) of 18.[34]

### Educational activity

Since 1996, Hoffmann has been actively teaching at the [AMU](/source/Adam_Mickiewicz_University_in_Pozna%C5%84) Faculty of Chemistry, partly in English. These classes include lectures, seminars, proseminars and laboratory exercises in a wide range of courses, from fundamental subjects, namely [physical chemistry](/source/Physical_chemistry), [quantum chemistry](/source/Quantum_chemistry) and [theoretical chemistry](/source/Theoretical_chemistry), to more specific ones, such as the application of [computational methods](/source/Computational_chemistry), [molecular modelling](/source/Molecular_modelling) and [online databases](/source/Online_database) in other [branches of chemistry](/source/Chemistry#Subdisciplines). He also worked as a teacher in X High School in [Poznań](/source/Pozna%C5%84) for two years (1999-2001).[2] During his career he has supervised several tens of [bachelor's](/source/Bachelor's_degree) and [master's](/source/Master's_degree) [theses](/source/Thesis), as well as four [doctoral dissertations](/source/Thesis):[35]

- Dr [Jakub Paś](/source/Jakub_Pa%C5%9B) (2013), dissertation title: *Application and implementation of [probabilistic](/source/Probability_theory) profile-profile comparison methods for [protein fold recognition](/source/Protein_structure_prediction)*.
- Dr Marcin Nowosielski (2015), dissertation title: *[Quantum](/source/Quantum_mechanics) and [classical mechanics](/source/Classical_mechanics) [computational methods](/source/Computational_chemistry) in [computer-aided drug design](/source/Drug_design#Computer-aided_drug_design).*
- Dr Wojciech Jankowski (2017), dissertation title: *[Quantum-chemical](/source/Quantum_chemistry) studies of [complexes](/source/Coordination_complex) of selected [alkaloids](/source/Alkaloid) with [zinc(II)](/source/Zinc) and [copper(II)](/source/Copper) [ions](/source/Ion).*
- Dr Martyna Kuta-Siejkowska (2018), dissertation title: *Studies on interactions of [protooncogenic](/source/Protooncogene) [G-quadruplexes](/source/G-quadruplex) with [ligands](/source/Ligand).*

He has also reviewed several tens of bachelor's and master's theses, seven doctoral dissertations, two habilitation processes and two applications for the professor title (by Dr hab. Mariusz Makowski, [UG](/source/Uniwersytet_Gda%C5%84ski) and Dr hab. Robert Wieczorek, [UWr](/source/Uniwersytet_Wroc%C5%82awski)).

### Organizational activity

For many years, Hoffmann has been actively working for the expansion of [Adam Mickiewicz University's](/source/Adam_Mickiewicz_University_in_Pozna%C5%84) scientific and educational abilities, for example by initiating and co-authoring *AMU – supranational and interdisciplinary solutions of 21st century* ([pl.](/source/Polish_language) *UAM – ponadnarodowe i interdyscyplinarne rozwiązania XXI wieku*) – a project co-funded by the [National Centre for Research and Development](/source/National_Centre_for_Research_and_Development_in_Poland), carried out in cooperation with the [University of Massachusetts Lowell](/source/University_of_Massachusetts_Lowell), and co-authoring [BSc](/source/Bachelor_of_Science), [MSc](/source/Master_of_Science) and [PhD](/source/Doctor_of_Philosophy) course programmes at the Faculty of Chemistry. He vigorously participates in organizing [science popularization events](/source/Popular_science) at the Faculty, such as [Poznań](/source/Pozna%C5%84) Festival of Science and Art or [European Researchers' Night](/source/European_Researchers'_Night). Since 2012, he has been serving as [Deputy Dean for Research](/source/Dean_(education)) (re-elected in 2016).[36] He is the initiator of and the [Secretary](/source/Secretary_(title)) of the [Jury](/source/Juried_(competition)) awarding [Jacek Rychlewski](/source/Jacek_Rychlewski) Prize of the [Polish Chemical Society](/source/Polish_Chemical_Society) for the best [MSc thesis](/source/Thesis) on [quantum chemistry](/source/Quantum_chemistry) or [exploiting quantum chemistry methods in other branches of science](/source/Computational_chemistry). He has reviewed and issued opinions on the implementation of research projects funded by the [National Science Centre](/source/The_National_Science_Centre_(Poland)), applications for grants for young scientists and project applications submitted to [Polish Grid Infrastructure PLGrid](/source/Polish_Grid_Infrastructure_PL-Grid). In 2013, in cooperation with [BioInfoBank Institute](/source/BioInfoBank_Institute) and [Interdisciplinary Centre for Mathematical and Computational Modelling](/source/Interdisciplinary_Centre_for_Mathematical_and_Computational_Modelling), Hoffmann organized an [international conference](/source/Academic_conference) *Advances in [Molecular Modelling](/source/Molecular_modelling)*. Since 2014, he is a member of the Scientific Committee of *All-Polish PhD Students' Seminar "Between Chemistry and Biology"* ([pl.](/source/Polish_language) *Ogólnopolskie Seminarium Doktorantów „Na pograniczu chemii i biologii”*).[37] He also [chaired](/source/Chairman) the proceeding of [theoretical](/source/Theoretical_chemistry) and [computational chemistry](/source/Computational_chemistry) section during the 59th Scientific Congress of the [Polish Chemical Society](/source/Polish_Chemical_Society) in 2016.[38]

## Other achievements

Aside from his academic work, Hoffmann has been widely cooperating with [high-tech enterprises](/source/High_tech), implementing the idea of [knowledge-based economy](/source/Knowledge_economy), for almost twenty years. In 2002–2003, he worked as [McKinsey & Company](/source/McKinsey_%26_Company) consultant, managing [telecommunications](/source/Telecommunication) and [energy carriers](/source/Energy_carrier); in 2004, he became the Director for Investments & Development at [BioInfoBank Institute](/source/BioInfoBank_Institute). In 2007, together with Leszek Rychlewski, he founded [BIB Seed Capital](/source/BIB_Seed_Capital) - a [seed capital fund](/source/Seed_money) focused on supporting [Polish](/source/Poland) scientific and engineering thought in such fields as [bioinformatics](/source/Bioinformatics), [molecular biology](/source/Molecular_biology), [chemistry](/source/Chemistry) and [computer science](/source/Computer_science), along with facilitating [its transfer](/source/Technology_transfer) to [small and medium-sized enterprises](/source/Small_and_medium-sized_enterprises).[39] Well-aimed [investments](/source/Investment) of the company, led by Hoffmann to the present day, allowed it to multiply its [financial resources](/source/Financial_capital), and some of the [startups](/source/Startup_company) it had funded became global players, such as:

- Medicalgorithmics S.A. – a Polish [high-tech](/source/High_tech) company, an expert in and a supplier of systemic and [algorithmic](/source/Algorithmics) solutions in [cardiac diagnosis](/source/Cardiology_diagnostic_tests_and_procedures); the company is listed on the [Warsaw Stock Exchange](/source/Warsaw_Stock_Exchange).[40]
- Proteon Pharmaceuticals S.A. – a Polish [pharmaceutical company](/source/Pharmaceutical_industry), which carries out research of [bacteriophages](/source/Bacteriophage) and uses them as a basis for developing novel [formulations](/source/Pharmaceutical_formulation) - successful substitutes for [antibiotics](/source/Antibiotic)[41]

Since 2010, he has worked as [expert witness](/source/Expert_witness) of the [District Court in Poznań](/source/Judiciary_of_Poland) in [exact sciences](/source/Exact_sciences), [economic sciences](/source/Economics) and [enterprise](/source/Company); he has also issued expert opinions for courts in other cities, including [Warsaw](/source/Warsaw), [Myślibórz](/source/My%C5%9Blib%C3%B3rz) and [Łowicz](/source/%C5%81owicz).[42]

## References

1. Responsible for higher education in Poland at that time.

1. Hoffmann 2014.

1. Cui, Q; Irle, S.; Musaev, J. (February 2018). "Keiji Morokuma (1934-2017)". *Angewandte Chemie International Edition*. **57** (9): 2288–2289. [doi:10.1002/anie.201800390](https://doi.org/10.1002/anie.201800390). [PMID 29392802](https://pubmed.ncbi.nlm.nih.gov/29392802)

1. ["Prezydent wręczył nominacje profesorskie"](https://web.archive.org/web/20171211064222/http://www.prezydent.pl/aktualnosci/nominacje/art,50,prezydent-wreczyl-nominacje-profesorskie.html) [The President conferred professor titles] (in Polish). *prezydent.pl*. 2017-03-08. Archived from [the original](http://www.prezydent.pl/aktualnosci/nominacje/art,50,prezydent-wreczyl-nominacje-profesorskie.html) on 2017-12-11. Retrieved 2018-10-29.

1. Hoffmann, M.; Rychlewski, J.; Rychlewska, U. (February 1999). "Effects of Substitution of OH Group by F Atom for Conformational Preferences of Fluorine-Substituted Analogues of (R, R)-Tartaric Acid, Its Dimethyl Diester, Diamide, and N, N, N ', N '-Tetramethyl Diamide. Ab Initio Conformational Analysis". *Journal of the American Chemical Society*. **121** (9): 1912–1921. [doi:10.1021/ja982935+](https://doi.org/10.1021/ja982935+)

1. Hoffmann, M. & Rychlewski, J. (March 2001). "Effects of substituting a OH group by a F atom in D-glucose. Ab initio and DFT analysis". *Journal of the American Chemical Society*. **123** (10): 2308–16. [doi:10.1021/ja003198w](https://doi.org/10.1021/ja003198w). [PMID 11456879](https://pubmed.ncbi.nlm.nih.gov/11456879)

1. Hoffmann, M. & Rychlewski, J. (July 2002). "When, in the context of drug design, can a fluorine atom successfully substitute a hydroxyl group?". *International Journal of Quantum Chemistry*. **89** (4): 419–427. [doi:10.1002/qua.10277](https://doi.org/10.1002/qua.10277)

1. Szarecka, A.; Hoffmann, M.; Rychlewski, J; Rychlewska, U. (January 1996). "X-ray diffraction and theoretical studies of the methyl ester of (R,R)-tartaric acid monoamide: semiempirical and ab initio calculations of some model compounds". *Journal of Molecular Structure*. **374** (1–3): 363–372. [Bibcode:1996JMoSt.374..363S](https://ui.adsabs.harvard.edu/abs/1996JMoSt.374..363S). [doi:10.1016/0022-2860(95)08928-4](https://doi.org/10.1016/0022-2860(95)08928-4)

1. Gawroński, J.; Gawrońska, K.; Skowronek, P.; Rychlewska, U. et al. (April 1997). "Factors affecting conformation of (R, R)-tartaric acid ester, amide and nitrile derivatives. X-ray diffraction, circular dichroism, nuclear magnetic resonance and ab initio studies". *Tetrahedron*. **53** (17): 6113–6144. [doi:10.1016/S0040-4020(97)00271-8](https://doi.org/10.1016/S0040-4020(97)00271-8)

1. Rychlewska, U.; Warżajtis, B.; Hoffmann, M.; Rychlewski, J. (July 1997). "(R, R)-Tartaric Acid Dimethyl Diester from X-Ray and Ab Initio Studies: Factors Influencing Its Conformation and Packing". *Molecules*. **2** (7): 106–113. [doi:10.3390/20700106](https://doi.org/10.3390/20700106)

1. Hoffmann, M.; Szarecka, A.; Rychlewski, J. (1998). *Gas-phase Conformational Analysis of (R, R)-Tartaric Acid, its Diamide, N, N, N′, N′-Tetramethyldiamide and Model Compounds*. Vol. 32. Advances in Quantum Chemistry. pp. 109–125. [doi:10.1016/S0065-3276(08)60409-8](https://doi.org/10.1016/S0065-3276(08)60409-8). ISBN 9780120348336.

1. Nowosielski, M.; Hoffmann, M.; Wyrwicz, L.S.; Stepniak, P. et al. (February 2011). "Detailed mechanism of squalene epoxidase inhibition by terbinafine". *Journal of Chemical Information and Modeling*. **51** (2): 455–62. [doi:10.1021/ci100403b](https://doi.org/10.1021/ci100403b). [PMID 21229992](https://pubmed.ncbi.nlm.nih.gov/21229992)

1. Sikorska, E.; Khmelinskii, I.; Kubicki, M.; Prukała, W. et al. (April 2006). "In search of excited-state proton transfer in the lumichrome dimer in the solid state: theoretical and experimental approach". *The Journal of Physical Chemistry A*. **110** (14): 4638–48. [Bibcode:2006JPCA..110.4638S](https://ui.adsabs.harvard.edu/abs/2006JPCA..110.4638S). [doi:10.1021/jp060072y](https://doi.org/10.1021/jp060072y). [PMID 16599430](https://pubmed.ncbi.nlm.nih.gov/16599430)

1. Sikorska, E.; Khmelinskii, I.; Hoffmann, M.; Machado, I.F. et al. (December 2005). "Ground- and excited-state double proton transfer in lumichrome/acetic acid system: theoretical and experimental approach". *The Journal of Physical Chemistry A*. **109** (51): 11707–14. [Bibcode:2005JPCA..10911707S](https://ui.adsabs.harvard.edu/abs/2005JPCA..10911707S). [doi:10.1021/jp053951d](https://doi.org/10.1021/jp053951d). [PMID 16366620](https://pubmed.ncbi.nlm.nih.gov/16366620)

1. Siodła, T.; Ozimiński, W.P.; Hoffmann, M.; Koroniak, H.; Krygowski, T.M. (August 2014). "Toward a physical interpretation of substituent effects: the case of fluorine and trifluoromethyl groups". *The Journal of Organic Chemistry*. **79** (16): 7321–31. [doi:10.1021/jo501013p](https://doi.org/10.1021/jo501013p). [PMID 25046196](https://pubmed.ncbi.nlm.nih.gov/25046196)

1. Hoffmann, M.; Rychlewski, J.; Chrzanowska, M.; Hermann, T. (July 2001). "Mechanism of activation of an immunosuppressive drug: azathioprine. Quantum chemical study on the reaction of azathioprine with cysteine". *Journal of the American Chemical Society*. **123** (26): 6404–9. [doi:10.1021/ja010378c](https://doi.org/10.1021/ja010378c). [PMID 11427067](https://pubmed.ncbi.nlm.nih.gov/11427067)

1. Patroniak, V.; Stefankiewicz, A.; Lehn, J.; Kubicki, M.; Hoffmann, M. (January 2006). "Self‐Assembly and Characterization of Homo‐ and Heterodinuclear Complexes of Zinc(II) and Lanthanide(III) Ions with a Tridentate Schiff‐Base Ligand". *European Journal of Inorganic Chemistry*. **2006** (1): 144–149. [doi:10.1002/ejic.200500699](https://doi.org/10.1002/ejic.200500699)

1. Hoffmann, M.; Chrzanowska, M.; Hermann, T.; Rychlewski, J. (June 2005). "Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations". *Journal of Medicinal Chemistry*. **48** (13): 4482–6. [doi:10.1021/jm0495273](https://doi.org/10.1021/jm0495273). [PMID 15974600](https://pubmed.ncbi.nlm.nih.gov/15974600)

1. Hoffmann, M.; Khavrutskii, I.V.; Musaev, D.G.; Morokuma, K. (June 2004). "Protein effects on the O2 binding to the active site of the methane monooxygenase: ONIOM studies". *International Journal of Quantum Chemistry*. **99** (6): 972–980. [doi:10.1002/qua.20141](https://doi.org/10.1002/qua.20141)

1. Giel-Pietraszuk, M.; Hoffmann, M.; Dolecka, S.; Rychlewski, J.; Barciszewski, J. (February 2003). "Palindromes in proteins". *Journal of Protein Chemistry*. **22** (2): 109–13. [doi:10.1023/a:1023454111924](https://doi.org/10.1023/a:1023454111924). [PMID 12760415](https://pubmed.ncbi.nlm.nih.gov/12760415). [S2CID 28294669](https://api.semanticscholar.org/CorpusID:28294669)

1. Marciniec, B.; Kownacka, A.; Kownacki, I.; Hoffmann, M.; Taylor, R. (August 2015). "Hydrosilylation vs. Dehydrogenative silylation of styrene catalysed by iron(0) carbonyl complexes with multivinylsilicon ligands – Mechanistic implications". *Journal of Organometallic Chemistry*. **791**: 58–65. [doi:10.1016/j.jorganchem.2015.04.051](https://doi.org/10.1016/j.jorganchem.2015.04.051)

1. Wyrwicz, L.S.; Gaj, P.; Hoffmann, M.; Rychlewski, L.; Ostrowski, J. (2007). "A common cis-element in promoters of protein synthesis and cell cycle genes". *Acta Biochimica Polonica*. **54** (1): 89–98. [doi:10.18388/abp.2007_3273](https://doi.org/10.18388/abp.2007_3273). [PMID 17351670](https://pubmed.ncbi.nlm.nih.gov/17351670)

1. Grabarkiewicz, T.; Grobelny, P.; Hoffmann, M.; Mielcarek, J. (December 2006). "DFT study on hydroxy acid-lactone interconversion of statins: The case of fluvastatin". *Org. Biomol. Chem.*. **4** (23): 4299–306. [doi:10.1039/b612999b](https://doi.org/10.1039/b612999b). [PMID 17102875](https://pubmed.ncbi.nlm.nih.gov/17102875)

1. Hoffmann, M. & Nowosielski, M. (October 2008). "DFT study on hydroxy acid-lactone interconversion of statins: the case of atorvastatin". *Organic & Biomolecular Chemistry*. **6** (19): 3527–31. [doi:10.1039/b803342k](https://doi.org/10.1039/b803342k). [PMID 19082153](https://pubmed.ncbi.nlm.nih.gov/19082153)

1. Plewczynski, D.; Hoffmann, M.; von Grotthuss, M.; Ginalski, K.; Rychewski, L. (April 2007). "In silico prediction of SARS protease inhibitors by virtual high throughput screening". *Chemical Biology & Drug Design*. **69** (4): 269–79. [doi:10.1111/j.1747-0285.2007.00475.x](https://doi.org/10.1111/j.1747-0285.2007.00475.x). [PMC 7188353](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188353). [PMID 17461975](https://pubmed.ncbi.nlm.nih.gov/17461975)

1. Hoffmann, M. & Torchała, M. (June 2009). "Search for inhibitors of aminoacyl-tRNA synthases by virtual click chemistry". *Journal of Molecular Modeling*. **15** (6): 665–72. [doi:10.1007/s00894-008-0421-x](https://doi.org/10.1007/s00894-008-0421-x). [PMID 19048310](https://pubmed.ncbi.nlm.nih.gov/19048310). [S2CID 207035662](https://api.semanticscholar.org/CorpusID:207035662)

1. Torchała, M. & Hoffmann, M. (September 2007). "IA, database of known ligands of aminoacyl-tRNA synthetases". *Journal of Computer-Aided Molecular Design*. **21** (9): 523–5. [Bibcode:2007JCAMD..21..523T](https://ui.adsabs.harvard.edu/abs/2007JCAMD..21..523T). [doi:10.1007/s10822-007-9135-x](https://doi.org/10.1007/s10822-007-9135-x). [PMID 17882381](https://pubmed.ncbi.nlm.nih.gov/17882381). [S2CID 27897915](https://api.semanticscholar.org/CorpusID:27897915)

1. Ratajewski, M.; Grzelak, I.; Wiśniewska, K.; Ryba, K. et al. (January 2015). "Screening of a chemical library reveals novel PXR-activating pharmacologic compounds". *Toxicology Letters*. **232** (1): 193–202. [doi:10.1016/j.toxlet.2014.10.009](https://doi.org/10.1016/j.toxlet.2014.10.009). [PMID 25455453](https://pubmed.ncbi.nlm.nih.gov/25455453)

1. Nowosielski, M.; Hoffmann, M.; Kuron, A.; Korycka-Machala, M.; Dziadek, J. (April 2013). "The MM2QM tool for combining docking, molecular dynamics, molecular mechanics, and quantum mechanics". *Journal of Computational Chemistry*. **34** (9): 750–6. [doi:10.1002/jcc.23192](https://doi.org/10.1002/jcc.23192). [PMID 23233437](https://pubmed.ncbi.nlm.nih.gov/23233437). [S2CID 659117](https://api.semanticscholar.org/CorpusID:659117)

1. Noureini, S.K.; Esmaeili, H.; Abachi, F.; Khiali, S. et al. (August 2017). ["Selectivity of major isoquinoline alkaloids from Chelidonium majus towards telomeric G-quadruplex: A study using a transition-FRET (t-FRET) assay"](https://discovery.ucl.ac.uk/id/eprint/1557444/). *Biochimica et Biophysica Acta (BBA) - General Subjects*. **1861** (8): 2020–2030. [doi:10.1016/j.bbagen.2017.05.002](https://doi.org/10.1016/j.bbagen.2017.05.002). [PMID 28479277](https://pubmed.ncbi.nlm.nih.gov/28479277)

1. Sokalska, M.; Prussakowska, M.; Hoffmann, M.; Gierczyk, B.; Frański, R. (October 2010). "Unusual ion UO(4)(-) formed upon collision induced dissociation of [UO(2)(NO(3))(3)](-), [UO(2)(ClO(4))(3)](-), [UO(2)(CH(3)COO)(3)](-) ions". *Journal of the American Society for Mass Spectrometry*. **21** (10): 1789–94. [doi:10.1016/j.jasms.2010.06.018](https://doi.org/10.1016/j.jasms.2010.06.018). [PMID 20678945](https://pubmed.ncbi.nlm.nih.gov/20678945)

1. ["Faculty of Chemistry of Adam Mickiewicz University in Poznań - Marcin Hoffmann"](https://web.archive.org/web/20180914165545/https://chemia.amu.edu.pl/glowna/wchem/struktura-wydziau/samodzielni-pracownicy-naukowi/prof.-uam-dr-hab.-marcin-hoffmann) (in Polish). Archived from [the original](https://chemia.amu.edu.pl/glowna/wchem/struktura-wydziau/samodzielni-pracownicy-naukowi/prof.-uam-dr-hab.-marcin-hoffmann) on 2018-09-14. Retrieved 2018-10-29.

1. ["XVI Na pograniczu chemii i biologii 2018 - Organizatorzy"](http://www.npcib.pl/commitees.php) [XVI Between Chemistry and Biology - Organizers]. Retrieved 2018-10-29.

1. ["59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego - Sekcje Zjazdu"](http://ptchem2016.amu.edu.pl/index.php/sekcje-zjazdu) [59th Scientific Congress of the Polish Chemical Society - Sections]. Retrieved 2018-10-29.

1. ["BIB Seed Capital"](http://seed.bioinfo.pl/en/). Retrieved 2018-10-29.

1. ["Medicalgorithmics"](http://www.medicalgorithmics.com/). Retrieved 2018-10-29.

1. ["Proteon Pharmaceuticals"](http://www.proteonpharma.com/). Retrieved 2018-10-29.

1. ["Lista biegłych sądowych Sądu Okręgowego w Poznaniu"](https://www.poznan.so.gov.pl/download/lista-bieglych-24.08.2018-r.-internet.pdf) [The register of expert witnesses of District Court in Poznań] (in Polish). Retrieved 2018-10-29.

## Sources

- Hoffmann, Marcin (2014). ["Curriculum Vitae"](https://web.archive.org/web/20160729225916/http://www.medicalgorithmics.com/pl/wp-content/uploads/2014/03/Marcin-Hoffmann.pdf) (in Polish). *medicalgorithmics.com*. Archived from [the original](http://www.medicalgorithmics.com/pl/wp-content/uploads/2014/03/Marcin-Hoffmann.pdf) on 2016-07-29. Retrieved 2018-10-29.

## External links

- [BIB Seed Capital](http://seed.bioinfo.pl/en/) (official website)

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Adapted from the Wikipedia article [Marcin Hoffmann](https://en.wikipedia.org/wiki/Marcin_Hoffmann) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Marcin_Hoffmann?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.