# Mangostin

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Mangostin
> Markdown URL: https://mediated.wiki/source/Mangostin.md
> Source: https://en.wikipedia.org/wiki/Mangostin
> Source revision: 1325796284
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 472254319
| ImageFile = mangostin structure.png
| ImageSize = 
| PIN = 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9''H''-xanthen-9-one
| OtherNames = alpha-mangostin
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 6147-11-1
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = U6RIV93RU1
| PubChem = 5281650
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 67547
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 323197 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4444969
| InChI = 1/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
| InChIKey = GNRIZKKCNOBBMO-UHFFFAOYAL
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GNRIZKKCNOBBMO-UHFFFAOYSA-N
| SMILES = CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C)C)O)C
  }}
|Section2={{Chembox Properties
| C=24 | H=26 | O=6
| Appearance = Yellow crystalline solid
| Density = 1.265 g/ml
| MeltingPtC = 182
| BoilingPt = 
| Solubility = 
  }}
|Section3={{Chembox Hazards
| MainHazards = 
| FlashPt = 
| AutoignitionPt = 
  }}
}}

'''Mangostin''' is a natural [xanthonoid](/source/xanthonoid), a type of organic compound isolated from various parts of the [mangosteen](/source/mangosteen) tree (''Garcinia mangostana'').  It is a yellow crystalline solid with a [xanthone](/source/xanthone) core structure.

==Source==
The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. Researchers conducted optimizations to increase the yield of α-mangostin extraction from the pericarp of the mangosteen and were able to achieve 9.2 g/kg DW.<ref>{{Cite journal| issue=1|doi=10.36877/pddbs.a0000072|title=A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin|year=2020|last1=Khaw|first1=Kooi Yeong|last2=Ong|first2=Yong Sze|last3=Goh|first3=Bey-Hing|journal=Progress in Drug Discovery & Biomedical Science|volume=3|doi-access=free}}</ref> The rind of fully ripe fruits also contains the xanthonoids [gartanin](/source/gartanin), [8-disoxygartanin](/source/8-disoxygartanin), and [normangostin](/source/normangostin).{{cn|date=August 2017}}

==Research==
Mangostin and a variety of other xanthonoids from mangosteen have been investigated for biological properties including [antioxidant](/source/antioxidant), anti-bacterial, anti-inflammatory, and anticancer activities.<ref>{{cite journal |vauthors=Jung H, Su B, Keller W, Mehta R, Kinghorn A |title=Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen) |journal=J. Agric. Food Chem. |volume=54 |issue=6 |pages=2077–82 |year=2006 |pmid=16536578 |doi=10.1021/jf052649z}}</ref>

In animal studies, mangostin has been found to be a [central nervous system](/source/central_nervous_system) depressant which causes [sedation](/source/sedation), decreased motor activity, and [ptosis](/source/Ptosis_(eyelid)).<ref>{{cite journal | journal=Arch Int Pharmacodyn Ther. |year=1979 |volume=239 | issue=2 |pages=257–269 |title=Pharmacological profile of mangostin and its derivatives |vauthors=Shankaranarayan D, Gopalakrishnan C, Kameswaran L |pmid=314790}}</ref>{{better source|date=August 2017}}

==Related compounds==
A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a [central nervous system](/source/central_nervous_system) [depressant](/source/depressant) and causes a rise in blood pressure.{{cn|date=August 2017}}

== References ==
{{Reflist}}

{{xanthonoid}}

Category:Xanthonoids
Category:Dietary antioxidants

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Adapted from the Wikipedia article [Mangostin](https://en.wikipedia.org/wiki/Mangostin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Mangostin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.