# MOCOS

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> Source: https://en.wikipedia.org/wiki/MOCOS
> Source revision: 1328193052
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"Molybdenum cofactor sulfurase" redirects here. For the similar enzyme in plants also sometimes called Molybdenum cofactor sulfurase, see [Molybdenum cofactor sulfurtransferase](/source/Molybdenum_cofactor_sulfurtransferase).

**Molybdenum cofactor sulfurase** is an [enzyme](/source/Enzyme) that in humans is encoded by the *MOCOS* [gene](/source/Gene).[1][2]

MOCOS sulfurates the [molybdenum cofactor](/source/Molybdopterin) of [xanthine dehydrogenase](/source/Xanthine_dehydrogenase) (XDH) and [aldehyde oxidase](/source/Aldehyde_oxidase_1) (AOX1), which is required for their enzymatic activities.[1]

## References

1. Ichida K, Matsumura T, Sakuma R, Hosoya T, Nishino T (April 2001). "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II". *Biochemical and Biophysical Research Communications*. **282** (5): 1194–200. [Bibcode:2001BBRC..282.1194I](https://ui.adsabs.harvard.edu/abs/2001BBRC..282.1194I). [doi:10.1006/bbrc.2001.4719](https://doi.org/10.1006/bbrc.2001.4719). [PMID 11302742](https://pubmed.ncbi.nlm.nih.gov/11302742)

1. ["Entrez Gene: MOCOS molybdenum cofactor sulfurase"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55034)

## Further reading

- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi:10.1016/0378-1119(94)90802-8](https://doi.org/10.1016/0378-1119(94)90802-8). [PMID 8125298](https://pubmed.ncbi.nlm.nih.gov/8125298)
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi:10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016/S0378-1119(97)00411-3). [PMID 9373149](https://pubmed.ncbi.nlm.nih.gov/9373149)
- Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Tuneyoshi K, Matsui K, Cheng J, Hada T (November 2003). "Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II". *Metabolism*. **52** (11): 1501–4. [doi:10.1016/s0026-0495(03)00272-5](https://doi.org/10.1016/s0026-0495(03)00272-5). [PMID 14624414](https://pubmed.ncbi.nlm.nih.gov/14624414)
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". *Nature Biotechnology*. **24** (10): 1285–92. [doi:10.1038/nbt1240](https://doi.org/10.1038/nbt1240). [PMID 16964243](https://pubmed.ncbi.nlm.nih.gov/16964243). [S2CID 14294292](https://api.semanticscholar.org/CorpusID:14294292)
- Peretz H, Naamati MS, Levartovsky D, Lagziel A, Shani E, Horn I, Shalev H, Landau D (May 2007). "Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria". *Molecular Genetics and Metabolism*. **91** (1): 23–9. [doi:10.1016/j.ymgme.2007.02.005](https://doi.org/10.1016/j.ymgme.2007.02.005). [PMID 17368066](https://pubmed.ncbi.nlm.nih.gov/17368066)

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Adapted from the Wikipedia article [MOCOS](https://en.wikipedia.org/wiki/MOCOS) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MOCOS?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.