# MIR660

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> Markdown URL: https://mediated.wiki/source/MIR660.md
> Source: https://en.wikipedia.org/wiki/MIR660
> Source revision: 1168389479
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Non-coding RNA in humans}}
{{Infobox_gene}}

'''MicroRNA 660''' is a [miRNA](/source/miRNA) that in humans is encoded by the MIR660 [gene](/source/gene).
<ref name="entrez">
{{cite web
| title = Entrez Gene: MicroRNA 660
| url = https://www.ncbi.nlm.nih.gov/gene/724030
| accessdate = 2015-09-11 <!-- T12:18:38.573646-08:00 --> 
}}</ref>

==Function==

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in [post-transcriptional regulation](/source/post-transcriptional_regulation) of gene expression in multicellular organisms by affecting both the stability and translation of [mRNAs](/source/mRNAs). miRNAs are transcribed by RNA polymerase II as part of capped and [polyadenylated](/source/Polyadenylation) primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the [Drosha ribonuclease](/source/Drosha) III enzyme to produce an approximately 70-[nt](/source/Nanotesla) stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the [cytoplasmic](/source/cytoplasmic) [Dicer ribonuclease](/source/Dicer) to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a [RNA-induced silencing complex (RISC)](/source/RNA-induced_silencing_complex), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

== References ==

{{reflist}}

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{{gene-X-stub}}

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Adapted from the Wikipedia article [MIR660](https://en.wikipedia.org/wiki/MIR660) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MIR660?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.