# MINPP1

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**Multiple inositol polyphosphate phosphatase 1** is an [enzyme](/source/Enzyme) that in humans is encoded by the *MINPP1* [gene](/source/Gene).[1][2]

MINPP1 [hydrolyzes](/source/Hydrolyzes) the abundant metabolites [inositol pentakisphosphate](/source/Inositol_pentakisphosphate) and [inositol hexakisphosphate](/source/Inositol_hexakisphosphate) and, like [PTEN](/source/PTEN_(gene)) (MIM 601728), has the ability to remove 3-phosphate from [inositol phosphate](/source/Inositol_phosphate) substrates.[supplied by OMIM][2]

## References

1. Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR (May 1999). "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19". *Genomics*. **56** (3): 324–36. [doi:10.1006/geno.1998.5736](https://doi.org/10.1006/geno.1998.5736). [PMID 10087200](https://pubmed.ncbi.nlm.nih.gov/10087200)

1. ["Entrez Gene: MINPP1 multiple inositol polyphosphate histidine phosphatase, 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9562)

## Further reading

- Romano PR, Wang J, O'Keefe RJ, etal (1998). "HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation". *J. Cell Sci.*. **111** (6): 803–13. [doi:10.1242/jcs.111.6.803](https://doi.org/10.1242/jcs.111.6.803). [PMID 9472008](https://pubmed.ncbi.nlm.nih.gov/9472008)
- Caffrey JJ, Hidaka K, Matsuda M, etal (1999). "The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification". *FEBS Lett.*. **442** (1): 99–104. [doi:10.1016/S0014-5793(98)01636-6](https://doi.org/10.1016/S0014-5793(98)01636-6). [PMID 9923613](https://pubmed.ncbi.nlm.nih.gov/9923613). [S2CID 7105717](https://api.semanticscholar.org/CorpusID:7105717)
- Chi H, Yang X, Kingsley PD, etal (2000). "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo". *Mol. Cell. Biol.*. **20** (17): 6496–507. [doi:10.1128/MCB.20.17.6496-6507.2000](https://doi.org/10.1128/MCB.20.17.6496-6507.2000). [PMC 86124](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86124). [PMID 10938126](https://pubmed.ncbi.nlm.nih.gov/10938126)
- Wiemann S, Weil B, Wellenreuther R, etal (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". *Genome Res.*. **11** (3): 422–35. [doi:10.1101/gr.GR1547R](https://doi.org/10.1101/gr.GR1547R). [PMC 311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID 11230166](https://pubmed.ncbi.nlm.nih.gov/11230166)
- Gimm O, Chi H, Dahia PL, etal (2001). "Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas". *J. Clin. Endocrinol. Metab.*. **86** (4): 1801–5. [doi:10.1210/jcem.86.4.7419](https://doi.org/10.1210/jcem.86.4.7419). [PMID 11297621](https://pubmed.ncbi.nlm.nih.gov/11297621)
- VanHouten JN, Asch HL, Asch BB (2001). "Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas". *Oncogene*. **20** (38): 5366–72. [doi:10.1038/sj.onc.1204701](https://doi.org/10.1038/sj.onc.1204701). [PMID 11536049](https://pubmed.ncbi.nlm.nih.gov/11536049). [S2CID 6474518](https://api.semanticscholar.org/CorpusID:6474518)
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Clark HF, Gurney AL, Abaya E, etal (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". *Genome Res.*. **13** (10): 2265–70. [doi:10.1101/gr.1293003](https://doi.org/10.1101/gr.1293003). [PMC 403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID 12975309](https://pubmed.ncbi.nlm.nih.gov/12975309)
- Deloukas P, Earthrowl ME, Grafham DV, etal (2004). "The DNA sequence and comparative analysis of human chromosome 10". *Nature*. **429** (6990): 375–81. [Bibcode:2004Natur.429..375D](https://ui.adsabs.harvard.edu/abs/2004Natur.429..375D). [doi:10.1038/nature02462](https://doi.org/10.1038/nature02462). [PMID 15164054](https://pubmed.ncbi.nlm.nih.gov/15164054)
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Liu T, Qian WJ, Gritsenko MA, etal (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". *J. Proteome Res.*. **4** (6): 2070–80. [doi:10.1021/pr0502065](https://doi.org/10.1021/pr0502065). [PMC 1850943](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850943). [PMID 16335952](https://pubmed.ncbi.nlm.nih.gov/16335952)
- Kimura K, Wakamatsu A, Suzuki Y, etal (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". *Genome Res.*. **16** (1): 55–65. [doi:10.1101/gr.4039406](https://doi.org/10.1101/gr.4039406). [PMC 1356129](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). [PMID 16344560](https://pubmed.ncbi.nlm.nih.gov/16344560)

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Adapted from the Wikipedia article [MINPP1](https://en.wikipedia.org/wiki/MINPP1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MINPP1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.