# MEX3D

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**Mex-3 homolog D (C. elegans)**, also known as **MEX3D**, is a [protein](/source/Protein) that in humans is encoded by the *MEX3D* [gene](/source/Gene).[1][2]

## Function

MEX3D is an RNA binding protein that interacts with [AU-rich elements](/source/AU-rich_element) of [Bcl-2](/source/Bcl-2). Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[2]

## Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ([KH domain](/source/KH_domain)) and a [RING domain](/source/RING_domain) at the C-terminus.[2]

## References

1. ["Entrez Gene: mex-3 homolog D (C. elegans)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=399664)

1. Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". *J. Biol. Chem.*. **279** (19): 20154–66. [doi:10.1074/jbc.M314071200](https://doi.org/10.1074/jbc.M314071200). [hdl:2158/356837](https://hdl.handle.net/2158/356837). [PMID 14769789](https://pubmed.ncbi.nlm.nih.gov/14769789)

## Further reading

- Strausberg RL, Feingold EA, Grouse LH, etal (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Buchet-Poyau K, Courchet J, Le Hir H, etal (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.". *Nucleic Acids Res.*. **35** (4): 1289–300. [doi:10.1093/nar/gkm016](https://doi.org/10.1093/nar/gkm016). [PMC 1851655](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851655). [PMID 17267406](https://pubmed.ncbi.nlm.nih.gov/17267406)

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Adapted from the Wikipedia article [MEX3D](https://en.wikipedia.org/wiki/MEX3D) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MEX3D?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.