# MED29

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/MED29
> Markdown URL: https://mediated.wiki/source/MED29.md
> Source: https://en.wikipedia.org/wiki/MED29
> Source revision: 995780908
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Infobox protein family
| Symbol = Med29
| Name = Med29
| image = 
| width = 
| caption = 
| Pfam = PF11568
| Pfam_clan =  
| InterPro = IPR021018
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
'''Mediator of RNA polymerase II transcription subunit 29''' ('''Med29''') is a [transcription suppressor](/source/Transcription_(genetics)) that in [humans](/source/humans) is encoded by the MED29 [gene](/source/gene).<ref name="pmid15555573">{{cite journal |vauthors=Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, etal | title=IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. | journal=Biochem Biophys Res Commun | year= 2004 | volume= 325 | issue= 4 | pages= 1330–8 | pmid=15555573 | doi=10.1016/j.bbrc.2004.10.159 }}</ref> It represents subunit MED29 of the [Mediator complex](/source/Mediator_(coactivator)).

Med29, along with [Med11](/source/MED11) and [Med28](/source/MED28) in [mammals](/source/mammals), is part of the core head-region of the [Mediator complex](/source/Mediator_(coactivator)). Med29 is the apparent [orthologue](/source/Homology_(biology)) of the ''[Drosophila melanogaster](/source/Drosophila_melanogaster)'' Intersex protein (IXL), which interacts directly with, and functions as a transcriptional [coactivator](/source/coactivator_(genetics)) for, the [DNA](/source/DNA)-binding [transcription](/source/transcription_(genetics)) factor [Doublesex](/source/Doublesex), so it is likely that [mammalia](/source/mammalia)n Med29 serves as a target for one or more DNA-binding [transcriptional activators](/source/transcriptional_activators).<ref name="pmid15896743">{{cite journal |vauthors=Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW | title = The mammalian Mediator complex and its role in transcriptional regulation | journal = Trends Biochem. Sci. | volume = 30 | issue = 5 | pages = 250–5 |date=May 2005 | pmid = 15896743 | doi = 10.1016/j.tibs.2005.03.002 }}</ref>

== See also ==
*[Mediator](/source/Mediator_(coactivator))

==References==
{{reflist}}
{{InterPro content|IPR021018}}

Category:Protein families

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Adapted from the Wikipedia article [MED29](https://en.wikipedia.org/wiki/MED29) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MED29?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.