# MDGA2

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> Markdown URL: https://mediated.wiki/source/MDGA2.md
> Source: https://en.wikipedia.org/wiki/MDGA2
> Source revision: 1300573711
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{protein
 |name=MAM domain containing glycosylphosphatidylinositol anchor 2
 |caption=
 |image=
 |width=
 |HGNCid=19835
 |Symbol=MDGA2
 |AltSymbols=MAMDC1
 |EntrezGene=161357
 |OMIM = 611128
 |RefSeq=NM_182830
 |UniProt=
 |PDB=
 |ECnumber=
 |Chromosome=14
 |Arm=q
 |Band=21.2
 |LocusSupplementaryData=
}}

'''''MDGA2''''' (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human [gene](/source/gene). 
It has previously been called ''MAMDC1''.<ref>{{Cite web
 | title = MDGA2 Gene &mdash; GeneCards
 | publisher = [Weizmann Institute of Science](/source/Weizmann_Institute_of_Science)
 | date = 2008-09-08
 | url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=MDGA2
}}</ref>
''MDGA2'' is located on [chromosome 14](/source/chromosome_14).

The gene has a [homologue](/source/homology_(biology)) in [rat](/source/rat) and [mouse](/source/mouse), ''Mdga2'',<ref>{{Cite web
 | url = http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=735131
 | title = Rat Genome Database: Mdga2 ( Rattus norvegicus )
 | publisher = Medical College of Wisconsin
 | accessdate = 2008-11-14
}}</ref>
and investigations in rats have found that the gene is expressed in the central and peripheral [nervous system](/source/nervous_system) in a subpopulation of [neurons](/source/neurons), e.g., in the basilar [pons](/source/pons) and [cerebral cortex](/source/cerebral_cortex).<ref>{{Cite journal
 | vauthors = Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD 
 | title = Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization
 | journal = [Molecular and Cellular Neuroscience](/source/Molecular_and_Cellular_Neuroscience)
 | volume = 25
 | issue = 2
 | pages = 263–264
 |date=February 2004
 | doi = 10.1016/j.mcn.2003.10.016
 | pmid = 15019943
| s2cid = 25186151
 }}</ref>

There are several variants in the human gene,<ref>{{Cite web
 | url = https://www.ncbi.nlm.nih.gov/variation/view/?q=161357[geneid]
 | title = SNP linked to Gene MDGA2
 | publisher = NCBI
}}</ref>
and a [genome-wide association study](/source/genome-wide_association_study) has pointed to that [single-nucleotide polymorphism](/source/single-nucleotide_polymorphism)s in ''MDGA2'' is associated with [neuroticism](/source/neuroticism).<ref>{{Cite journal
 | title = 18762592
 | vauthors = van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D 
 | journal = [Archives of General Psychiatry](/source/Archives_of_General_Psychiatry)
 | volume = 65
 | issue = 9
 | pages = 1062&ndash;1071
 |date=September 2008
 | pmid = 18762592
 | url = http://archpsyc.ama-assn.org/cgi/content/full/65/9/1062
 | doi = 10.1001/archpsyc.65.9.1062
| doi-access = 
 | url-access = subscription
 }}</ref> However, a more recent study has failed to replicate that finding.<ref>{{Cite journal|last1=Hettema|first1=John M.|last2=Oord|first2=Edwin J.C.G. van den|last3=An|first3=Seon-Sook|last4=Kendler|first4=Kenneth S.|last5=Chen|first5=Xiangning|title=Follow-up association study of novel neuroticism gene MAMDC1|url=https://dx.doi.org/10.1097/ypg.0b013e32832cec22|journal=Psychiatric Genetics|volume=19|issue=4|pages=213–214|doi=10.1097/ypg.0b013e32832cec22|pmc=2844892|pmid=19440164|year=2009}}</ref>

== References ==
{{Reflist}}

Category:Genes on human chromosome 14

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Adapted from the Wikipedia article [MDGA2](https://en.wikipedia.org/wiki/MDGA2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MDGA2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.