# MCEF

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> Markdown URL: https://mediated.wiki/source/MCEF.md
> Source: https://en.wikipedia.org/wiki/MCEF
> Source revision: 1317783371
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{{Short description|Transcription factor}}
{{infobox protein
|Name=AF4/FMR2 family, member 4
|caption=
|image=
|width=
|HGNCid=17869
|Symbol=AFF4
|AltSymbols=
|EntrezGene=27125
|OMIM=604417
|RefSeq=NM_014423
|UniProt=Q9UHB7
|PDB=
|ECnumber=
|Chromosome=5
|Arm=q
|Band=31
|LocusSupplementaryData=
}}
'''MCEF''' or Major [Cdk9](/source/Cdk9)-interacting [elongation factor](/source/elongation_factor) is a [transcription factor](/source/transcription_factor) related to Af4.  It is the fourth member of the Af4 family (AFF) of transcription factors, involved in numerous pathologies, including [Acute Lymphoblastic Leukemia](/source/Acute_Lymphoblastic_Leukemia) (ALL), abnormal [CNS](/source/Central_nervous_system) development, [breast cancer](/source/breast_cancer) and [azoospermia](/source/azoospermia).

Because it apparently interacts with the species-specific human co-factor ([P-TEFb](/source/P-TEFb)) for HIV-1 transcription, and because it can repress HIV-1 replication, MCEF (also known as AFF4 or AF5q31) may have future therapeutic uses.<ref name=Estable>{{cite journal |vauthors=Estable M, Naghavi M, Kato H, Xiao H, Qin J, Vahlne A, Roeder R |author6-link=Anders Vahlne |title=MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein |journal=J Biomed Sci |volume=9 |issue=3 |pages=234–245 |year=2002 |pmid=12065898 |doi=10.1007/BF02256070}}</ref>

MCEF was originally cloned and named by Mario Clemente Estable of [Ryerson University](/source/Ryerson_University), while he was a post-doctoral fellow in the laboratory of [Robert G. Roeder](/source/Robert_G._Roeder), at the [Rockefeller University](/source/Rockefeller_University).

==See also==
[Transcription factors](/source/Transcription_factors)

==References==
<references/>

*{{cite journal |vauthors=Niedzielski MF, Hopewell R, Ismail Z, Estable MC |title=MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription |journal=Int J Biol Sci |volume=3 |issue=4 |pages=225–236 |year=2007 |doi=10.7150/ijbs.3.225 |pmid=17389929 |pmc=1820876}}
* {{MeshName|MCEF+protein,+human}}

Category:Transcription factors
Category:Oncogenes

{{biochem-stub}}

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Adapted from the Wikipedia article [MCEF](https://en.wikipedia.org/wiki/MCEF) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MCEF?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.