# MAPK8IP3

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Protein-coding gene in the species Homo sapiens

MAPK8IP3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PXJ Identifiers Aliases MAPK8IP3, JIP3, JSAP1, SYD2, syd, JIP-3, mitogen-activated protein kinase 8 interacting protein 3 External IDs OMIM: 605431; MGI: 1353598; HomoloGene: 22790; GeneCards: MAPK8IP3; OMA:MAPK8IP3 - orthologs Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,706,183 bp[1] End 1,770,317 bp[1] Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.53 cM Start 25,111,127 bp[2] End 25,155,951 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe anterior pituitary prefrontal cortex granulocyte sural nerve cingulate gyrus left ovary anterior cingulate cortex right ovary Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus neural layer of retina primary visual cortex perirhinal cortex entorhinal cortex central gray substance of midbrain cerebellar cortex superior colliculus CA3 field More reference expression data BioGPS More reference expression data Gene ontology Molecular function signaling receptor complex adaptor activity protein binding MAP-kinase scaffold activity JUN kinase binding kinesin binding Cellular component cytoplasm Golgi membrane axon dendrite cell body perinuclear region of cytoplasm axon cytoplasm Golgi apparatus growth cone cytoplasmic vesicle cell projection Biological process vesicle-mediated transport regulation of JNK cascade axon regeneration axon development anterograde axonal protein transport Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 23162 30957 Ensembl ENSG00000138834 ENSMUSG00000024163 UniProt Q9UPT6 Q9ESN9 RefSeq (mRNA) NM_001040439 NM_015133 NM_001318852 NM_001163447 NM_001163448 NM_001163449 NM_001163450 NM_001163451 NM_001163453 NM_013931 RefSeq (protein) NP_001035529 NP_001305781 NP_055948 NP_001156919 NP_001156920 NP_001156921 NP_001156922 NP_001156923 NP_001156925 NP_038959 Location (UCSC) Chr 16: 1.71 – 1.77 Mb Chr 17: 25.11 – 25.16 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**C-jun-amino-terminal kinase-interacting protein 3** is an [enzyme](/source/Enzyme) that in humans is encoded by the *MAPK8IP3* [gene](/source/Gene).[5][6][7]

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]

## Interactions

MAPK8IP3 has been shown to [interact](/source/Protein-protein_interaction) with [ASK1](/source/ASK1),[8] [C-Raf](/source/C-Raf),[5][9] [PTK2](/source/PTK2),[10] [MAPK10](/source/MAPK10),[5][6][8] [Mitogen-activated protein kinase 9](/source/Mitogen-activated_protein_kinase_9),[5][6] [MAPK8](/source/MAPK8),[5][6] [MAP2K1](/source/MAP2K1),[5][9] [KLC2](/source/KLC2),[11] [MAP2K7](/source/MAP2K7),[6][8] [KLC1](/source/KLC1),[11] [MAPK8IP2](/source/MAPK8IP2)[6] and [MAP2K4](/source/MAP2K4).[5][8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000138834](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000138834) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000024163](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024163) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=23162). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=30957). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-pmid10523642_5-0) [***b***](#cite_ref-pmid10523642_5-1) [***c***](#cite_ref-pmid10523642_5-2) [***d***](#cite_ref-pmid10523642_5-3) [***e***](#cite_ref-pmid10523642_5-4) [***f***](#cite_ref-pmid10523642_5-5) [***g***](#cite_ref-pmid10523642_5-6) Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). ["JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84763). *Mol Cell Biol*. **19** (11): 7539–48. [doi](/source/Doi_(identifier)):[10.1128/mcb.19.11.7539](https://doi.org/10.1128%2Fmcb.19.11.7539). [PMC](/source/PMC_(identifier)) [84763](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84763). [PMID](/source/PMID_(identifier)) [10523642](https://pubmed.ncbi.nlm.nih.gov/10523642).

1. ^ [***a***](#cite_ref-pmid10629060_6-0) [***b***](#cite_ref-pmid10629060_6-1) [***c***](#cite_ref-pmid10629060_6-2) [***d***](#cite_ref-pmid10629060_6-3) [***e***](#cite_ref-pmid10629060_6-4) [***f***](#cite_ref-pmid10629060_6-5) Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). ["Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85220). *Mol Cell Biol*. **20** (3): 1030–43. [doi](/source/Doi_(identifier)):[10.1128/MCB.20.3.1030-1043.2000](https://doi.org/10.1128%2FMCB.20.3.1030-1043.2000). [PMC](/source/PMC_(identifier)) [85220](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85220). [PMID](/source/PMID_(identifier)) [10629060](https://pubmed.ncbi.nlm.nih.gov/10629060).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23162).

1. ^ [***a***](#cite_ref-pmid12189133_8-0) [***b***](#cite_ref-pmid12189133_8-1) [***c***](#cite_ref-pmid12189133_8-2) [***d***](#cite_ref-pmid12189133_8-3) Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). ["Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"](https://doi.org/10.1074%2Fjbc.M202004200). *J. Biol. Chem*. **277** (43). United States: 40703–9. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202004200](https://doi.org/10.1074%2Fjbc.M202004200). [hdl](/source/Hdl_(identifier)):[2297/2692](https://hdl.handle.net/2297%2F2692). [ISSN](/source/ISSN_(identifier)) [0021-9258](https://search.worldcat.org/issn/0021-9258). [PMID](/source/PMID_(identifier)) [12189133](https://pubmed.ncbi.nlm.nih.gov/12189133).

1. ^ [***a***](#cite_ref-pmid11044439_9-0) [***b***](#cite_ref-pmid11044439_9-1) Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (December 2000). ["A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways"](https://doi.org/10.1074%2Fjbc.C000403200). *J. Biol. Chem*. **275** (51). UNITED STATES: 39815–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.C000403200](https://doi.org/10.1074%2Fjbc.C000403200). [ISSN](/source/ISSN_(identifier)) [0021-9258](https://search.worldcat.org/issn/0021-9258). [PMID](/source/PMID_(identifier)) [11044439](https://pubmed.ncbi.nlm.nih.gov/11044439).

1. **[^](#cite_ref-pmid12226752_10-0)** Takino, Takahisa; Yoshioka Katsuji; Miyamori Hisashi; Yamada Kenneth M; Sato Hiroshi (September 2002). ["A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated"](https://doi.org/10.1038%2Fsj.onc.1205840). *Oncogene*. **21** (42). England: 6488–97. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1205840](https://doi.org/10.1038%2Fsj.onc.1205840). [hdl](/source/Hdl_(identifier)):[2297/2669](https://hdl.handle.net/2297%2F2669). [ISSN](/source/ISSN_(identifier)) [0950-9232](https://search.worldcat.org/issn/0950-9232). [PMID](/source/PMID_(identifier)) [12226752](https://pubmed.ncbi.nlm.nih.gov/12226752).

1. ^ [***a***](#cite_ref-pmid11106729_11-0) [***b***](#cite_ref-pmid11106729_11-1) Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). ["Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein"](https://doi.org/10.1016%2FS0092-8674%2800%2900162-8). *Cell*. **103** (4). UNITED STATES: 583–94. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(00)00162-8](https://doi.org/10.1016%2FS0092-8674%2800%2900162-8). [ISSN](/source/ISSN_(identifier)) [0092-8674](https://search.worldcat.org/issn/0092-8674). [PMID](/source/PMID_(identifier)) [11106729](https://pubmed.ncbi.nlm.nih.gov/11106729). [S2CID](/source/S2CID_(identifier)) [247102](https://api.semanticscholar.org/CorpusID:247102).

## Further reading

- Kikuno R, Nagase T, Ishikawa K, et al. (1999). ["Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"](https://doi.org/10.1093%2Fdnares%2F6.3.197). *DNA Res*. **6** (3): 197–205. [doi](/source/Doi_(identifier)):[10.1093/dnares/6.3.197](https://doi.org/10.1093%2Fdnares%2F6.3.197). [PMID](/source/PMID_(identifier)) [10470851](https://pubmed.ncbi.nlm.nih.gov/10470851).

- Kuboki Y, Ito M, Takamatsu N, et al. (2001). ["A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways"](https://doi.org/10.1074%2Fjbc.C000403200). *J. Biol. Chem*. **275** (51): 39815–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.C000403200](https://doi.org/10.1074%2Fjbc.C000403200). [PMID](/source/PMID_(identifier)) [11044439](https://pubmed.ncbi.nlm.nih.gov/11044439).

- Bowman AB, Kamal A, Ritchings BW, et al. (2001). ["Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein"](https://doi.org/10.1016%2FS0092-8674%2800%2900162-8). *Cell*. **103** (4): 583–94. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(00)00162-8](https://doi.org/10.1016%2FS0092-8674%2800%2900162-8). [PMID](/source/PMID_(identifier)) [11106729](https://pubmed.ncbi.nlm.nih.gov/11106729). [S2CID](/source/S2CID_(identifier)) [247102](https://api.semanticscholar.org/CorpusID:247102).

- Daniels RJ, Peden JF, Lloyd C, et al. (2001). ["Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16"](https://doi.org/10.1093%2Fhmg%2F10.4.339). *Hum. Mol. Genet*. **10** (4): 339–52. [doi](/source/Doi_(identifier)):[10.1093/hmg/10.4.339](https://doi.org/10.1093%2Fhmg%2F10.4.339). [PMID](/source/PMID_(identifier)) [11157797](https://pubmed.ncbi.nlm.nih.gov/11157797).

- Hattori A, Okumura K, Nagase T, et al. (2001). ["Characterization of long cDNA clones from human adult spleen"](https://doi.org/10.1093%2Fdnares%2F7.6.357). *DNA Res*. **7** (6): 357–66. [doi](/source/Doi_(identifier)):[10.1093/dnares/7.6.357](https://doi.org/10.1093%2Fdnares%2F7.6.357). [PMID](/source/PMID_(identifier)) [11214971](https://pubmed.ncbi.nlm.nih.gov/11214971).

- Akechi M, Ito M, Uemura K, et al. (2001). "Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system". *Neurosci. Res*. **39** (4): 391–400. [doi](/source/Doi_(identifier)):[10.1016/S0168-0102(01)00194-8](https://doi.org/10.1016%2FS0168-0102%2801%2900194-8). [PMID](/source/PMID_(identifier)) [11274738](https://pubmed.ncbi.nlm.nih.gov/11274738). [S2CID](/source/S2CID_(identifier)) [37577286](https://api.semanticscholar.org/CorpusID:37577286).

- Byrd DT, Kawasaki M, Walcoff M, et al. (2002). ["UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans"](https://doi.org/10.1016%2FS0896-6273%2801%2900532-3). *Neuron*. **32** (5): 787–800. [doi](/source/Doi_(identifier)):[10.1016/S0896-6273(01)00532-3](https://doi.org/10.1016%2FS0896-6273%2801%2900532-3). [PMID](/source/PMID_(identifier)) [11738026](https://pubmed.ncbi.nlm.nih.gov/11738026). [S2CID](/source/S2CID_(identifier)) [16942260](https://api.semanticscholar.org/CorpusID:16942260).

- Matsuura H, Nishitoh H, Takeda K, et al. (2002). ["Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"](https://doi.org/10.1074%2Fjbc.M202004200). *J. Biol. Chem*. **277** (43): 40703–9. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202004200](https://doi.org/10.1074%2Fjbc.M202004200). [hdl](/source/Hdl_(identifier)):[2297/2692](https://hdl.handle.net/2297%2F2692). [PMID](/source/PMID_(identifier)) [12189133](https://pubmed.ncbi.nlm.nih.gov/12189133).

- Takino T, Yoshioka K, Miyamori H, et al. (2002). ["A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated"](https://doi.org/10.1038%2Fsj.onc.1205840). *Oncogene*. **21** (42): 6488–97. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1205840](https://doi.org/10.1038%2Fsj.onc.1205840). [hdl](/source/Hdl_(identifier)):[2297/2669](https://hdl.handle.net/2297%2F2669). [PMID](/source/PMID_(identifier)) [12226752](https://pubmed.ncbi.nlm.nih.gov/12226752).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". *Nat. Biotechnol*. **22** (6): 707–16. [doi](/source/Doi_(identifier)):[10.1038/nbt971](https://doi.org/10.1038%2Fnbt971). [PMID](/source/PMID_(identifier)) [15146197](https://pubmed.ncbi.nlm.nih.gov/15146197). [S2CID](/source/S2CID_(identifier)) [27764390](https://api.semanticscholar.org/CorpusID:27764390).

- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). ["Large-scale characterization of HeLa cell nuclear phosphoproteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). *Proc. Natl. Acad. Sci. U.S.A*. **101** (33): 12130–5. [Bibcode](/source/Bibcode_(identifier)):[2004PNAS..10112130B](https://ui.adsabs.harvard.edu/abs/2004PNAS..10112130B). [doi](/source/Doi_(identifier)):[10.1073/pnas.0404720101](https://doi.org/10.1073%2Fpnas.0404720101). [PMC](/source/PMC_(identifier)) [514446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). [PMID](/source/PMID_(identifier)) [15302935](https://pubmed.ncbi.nlm.nih.gov/15302935).

- Morita N, Iizuka K, Murakami T, Kawaguchi H (2005). "N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress". *Mol. Cell. Biochem*. **262** (1–2): 71–8. [doi](/source/Doi_(identifier)):[10.1023/B:MCBI.0000038218.09259.1c](https://doi.org/10.1023%2FB%3AMCBI.0000038218.09259.1c). [PMID](/source/PMID_(identifier)) [15532711](https://pubmed.ncbi.nlm.nih.gov/15532711). [S2CID](/source/S2CID_(identifier)) [23799480](https://api.semanticscholar.org/CorpusID:23799480).

- Martin J, Han C, Gordon LA, et al. (2005). ["The sequence and analysis of duplication-rich human chromosome 16"](https://doi.org/10.1038%2Fnature03187). *Nature*. **432** (7020): 988–94. [Bibcode](/source/Bibcode_(identifier)):[2004Natur.432..988M](https://ui.adsabs.harvard.edu/abs/2004Natur.432..988M). [doi](/source/Doi_(identifier)):[10.1038/nature03187](https://doi.org/10.1038%2Fnature03187). [PMID](/source/PMID_(identifier)) [15616553](https://pubmed.ncbi.nlm.nih.gov/15616553).

- Song JJ, Lee YJ (2005). ["Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators"](https://doi.org/10.1074%2Fjbc.M502318200). *J. Biol. Chem*. **280** (29): 26845–55. [doi](/source/Doi_(identifier)):[10.1074/jbc.M502318200](https://doi.org/10.1074%2Fjbc.M502318200). [PMID](/source/PMID_(identifier)) [15911620](https://pubmed.ncbi.nlm.nih.gov/15911620).

- Takino T, Nakada M, Miyamori H, et al. (2006). ["JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration"](https://doi.org/10.1074%2Fjbc.M505241200). *J. Biol. Chem*. **280** (45): 37772–81. [doi](/source/Doi_(identifier)):[10.1074/jbc.M505241200](https://doi.org/10.1074%2Fjbc.M505241200). [PMID](/source/PMID_(identifier)) [16141199](https://pubmed.ncbi.nlm.nih.gov/16141199).

- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". *Mamm. Genome*. **16** (12): 942–54. [doi](/source/Doi_(identifier)):[10.1007/s00335-005-0075-2](https://doi.org/10.1007%2Fs00335-005-0075-2). [PMID](/source/PMID_(identifier)) [16341674](https://pubmed.ncbi.nlm.nih.gov/16341674). [S2CID](/source/S2CID_(identifier)) [69278](https://api.semanticscholar.org/CorpusID:69278).

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Adapted from the Wikipedia article [MAPK8IP3](https://en.wikipedia.org/wiki/MAPK8IP3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/MAPK8IP3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.