# Liotrix

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Liotrix
> Markdown URL: https://mediated.wiki/source/Liotrix.md
> Source: https://en.wikipedia.org/wiki/Liotrix
> Source revision: 1211503394
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Chemical compound}}
{{Drugbox
| type              = combo
| component1        = Thyroxine
| class1            = [Thyroid hormone](/source/Thyroid_hormone)
| component2        = Triiodothyronine
| class2            = Thyroid hormone

<!-- Clinical data -->
| tradename         = Thyrolar
| Drugs.com         = {{Drugs.com|MTM|thyrolar-1}}
| MedlinePlus       = 
| pregnancy_AU      = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      = A
| pregnancy_category= 
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = Rx
| legal_status      = 
| routes_of_administration = Oral

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number        = 8065-29-0
| ATCvet            = 
| ATC_prefix        = H03
| ATC_suffix        = AA03
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII              = YW8HJ0N26X
| PubChem           = 165686
| DrugBank          = DB01583
| KEGG          = D00361
| ChemSpiderID      = none
}}
'''Liotrix''' is a 4:1 mixture of [thyroxine](/source/thyroxine) (T<sub>4</sub>) and [triiodothyronine](/source/triiodothyronine) (T<sub>3</sub>) made synthetically. It is used to replenish [thyroid hormone](/source/thyroid_hormone)s in thyroid deficiency and [hypothyroidism](/source/hypothyroidism). The only brand of liotrix available in the U.S. is '''Thyrolar''', manufactured by [Forest Laboratories](/source/Forest_Laboratories).

Sometime prior to 2008 Forest Laboratories released the following statement regarding the limited availability of liotrix: "U.S. Pharmacopeia, an official public standards-setting authority for prescription and over-the-counter medicines and other health care products manufactured or sold in the United States, has mandated new specifications for a component used in the manufacturing of Thyrolar. As a result, all strengths of Thyrolar are currently on long-term back order while modifications necessary to meet these new specifications are made."<ref>{{cite web | title = Thyrolar | url = http://www.thyrolar.com/ | archive-url = https://web.archive.org/web/20080811224357/http://www.thyrolar.com/ | archive-date = 11 August 2008 | work = Forest Pharmaceuticals, Inc. }}</ref>

== Indications ==

The most common usage is hypothyroidism treatment, via supplementation.<ref name="drugs.com">{{Cite web|url=https://www.drugs.com/ppa/liotrix.html|title = Liotrix (Professional Patient Advice)}}</ref><ref>{{cite book | vauthors = Skidmore-Roth L |title=Mosby's 2015 nursing drug reference |date=2015 |publisher=Elsevier Health Sciences |location=Saint Louis, Missouri |isbn=978-0-323-28693-0 |page=713 |edition=Twenty-eight | chapter = Liotrix | chapter-url=https://books.google.com/books?id=9cQFBAAAQBAJ&dq=Liotrix&pg=PA713}}</ref>
Other uses include:
* [Hashimoto's thyroiditis](/source/Hashimoto's_thyroiditis) 
*[Congenital hypothyroidism](/source/Congenital_hypothyroidism)  
*[Goiter](/source/Goiter) treatment with [thyroid stimulating hormone](/source/thyroid_stimulating_hormone) suppression
*management of [thyroid cancer](/source/thyroid_cancer)
*as an agent in a [differential diagnosis](/source/differential_diagnosis) of [hyperthyroidism](/source/hyperthyroidism) and [thyroid gland autonomy](/source/thyroid_gland_autonomy)

== Adverse effects ==
Adverse effects are mainly due to chronic accidental [overdose](/source/overdose). Symptoms mimic those of hyperthyroidism and include [headache](/source/headache), [chest pain](/source/chest_pain), [irregular heartbeat](/source/irregular_heartbeat), [dyspnea](/source/dyspnea), [trembling](/source/trembling), [sweating](/source/sweating), [diarrhea](/source/diarrhea), and weight loss. These effects can be reduced through [titration](/source/titration) of the dose levels, but this should be done by the prescribing physician.<ref name="medicinenet">{{Cite web|url=http://www.medicinenet.com/liotrix-oral/article.htm|title=LIOTRIX - ORAL (Thyrolar) side effects, medical uses, and drug interactions | work = MedicineNet }}</ref>
[Sympathomimetic cardiovascular](/source/Sympathomimetic_cardiovascular) effects including: heart palpitations, chest pain, arrhythmia, sweating, chest pain, and anxiety, require urgent medical attention.<ref name="reference.medscape.com">{{Cite web|url=http://reference.medscape.com/drug/thyrolar-liotrix-342737#91 | work = MedScape |title = Thyrolar (Liotrix) dosing, indications, interactions, adverse effects, and more}}</ref> Particularly if these signs occur in patients who are at an increased risk for cardiovascular complications i.e. familial or patient history of myocardial infarction, cardiovascular disease, stroke, arteriosclerosis.<ref name="drugs.com"/> 
Hair loss occasionally occurs in the first few months of treatment, but is reversible. The condition is usually self-limiting without altering treatment.<ref name="reference.medscape.com"/>

== Contraindications ==
Thyroid agents should not be used to treat [obesity](/source/obesity), particularly in [euthyroid](/source/euthyroid) [patients](/source/patients). Regular doses in hypothyroid patients are acceptable, but only in the context of treating hypothyroidism. Excessive doses (and regular doses in euthyroid patients) can result in life-threatening cardiovascular events. Patients should be advised against taking sympathomimetic agents, including stimulants and diet pills, while undergoing hypothyroid treatment, as these agents increase the risk of cardiovascular events.<ref>{{Cite web|url=http://reference.medscape.com/drug/thyrolar-liotrix-342737#5|title=Thyrolar (Liotrix) dosing, indications, interactions, adverse effects, and more | work = MedScape }}</ref>

==References==
{{Reflist}}

{{Thyroid therapy}}
{{Thyroid hormone receptor modulators}}

Category:Hormones of the thyroid gland
Category:Combination drugs
Category:Thyroid
Category:Thyroid hormone receptor agonists

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Adapted from the Wikipedia article [Liotrix](https://en.wikipedia.org/wiki/Liotrix) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Liotrix?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.