# Leucines

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The **leucines** are primarily the four [isomeric](/source/Isomer) [amino acids](/source/Amino_acid): [leucine](/source/Leucine), [isoleucine](/source/Isoleucine), [*tert*-leucine](/source/Tert-Leucine) ([terleucine](/source/Terleucine), [pseudoleucine](/source/Pseudoleucine)) and [norleucine](/source/Norleucine).[1] Being compared with the four [butanols](/source/Butanol), they could be classified as butyl-substituted [glycines](/source/Glycine); they represent all four possible variations.

Leucine and isoleucine belong to the [proteinogenic amino acids](/source/Proteinogenic_amino_acid); the others are non-natural.

## Isomers

Including the stereoisomers, six further isomers could be added: D-leucine, D-isoleucine, L-[alloisoleucine](/source/Alloisoleucine), D-alloisoleucine, D-*tert*-leucine and D-norleucine.

Leucines Name L-Leucine L-Isoleucine L-tert-Leucine (terleucine, pseudoleucine) L-Norleucine Other names 2-Amino-4-methylpentanoic acid, Isobutylglycine 2-Amino-3-methylpentanoic acid, sec-Butylglycine 2-Amino-3,3-dimethylbutanoic acid, tert-Butylglycine 2-Amino-hexanoic acid, n-Butylglycine Structure CAS-number 61-90-5 73-32-5 20859-02-3 327-57-1 PubChem Molecular formula C6H13NO2 Molar mass 131.18 g/mol

## Derivatives

[Cycloleucine](/source/Cycloleucine) could be classified as a cyclic derivative of [norleucine](/source/Norleucine). With a [cyclopentane](/source/Cyclopentane)-ring, it has two hydrogen atoms fewer and thus is not an isomer. The α-carbon atom is not a stereocenter.

## See also

- [L-Photo-Leucine](/source/L-Photo-Leucine)

## Literature

- Jeremy M. Berg, John L. Tymoczko, [Lubert Stryer](/source/Lubert_Stryer): *Biochemie.* 6 Auflage, Spektrum Akademischer Verlag, Heidelberg 2007. ISBN 978-3-8274-1800-5.
- Donald Voet, Judith G. Voet: *Biochemistry.* 3. Auflage, John Wiley & Sons, New York 2004. ISBN 0-471-19350-X.
- [Bruce Alberts](/source/Bruce_Alberts), Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: *Molecular Biology of the Cell*, 5. Auflage, Taylor & Francis 2007, ISBN 978-0815341062.

## References

1. Zaremska, Valeriia; Tan, Jiajun; Lim, Sierin; Knoll, Wolfgang; Pelosi, Paolo (2020-07-17). ["Isoleucine Residues Determine Chiral Discrimination of Odorant‐Binding Protein"](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202000872). *Chemistry – A European Journal*. **26** (40): 8720–8724. [doi:10.1002/chem.202000872](https://doi.org/10.1002/chem.202000872). [ISSN 0947-6539](https://www.worldcat.org/issn/0947-6539)

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