# Large cell

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{{short description|Term used in oncology}}
[[File:Tumor giant cell.jpg|thumbnail|[Micrograph](/source/Micrograph) showing large cells. [H&E](/source/H%26E) stain.]]
'''Large cell''' is a term used in [oncology](/source/oncology). It does not refer to a particular type of cell; rather it refers to cells that are larger than would be normally expected for that type. It is frequently used when describing [lymphoma](/source/lymphoma) and [lung cancer](/source/lung_cancer).

It was more frequently used in the past than it is used today, when doctors often could tell little about a cell other than its size, and it was used for classification systems such as the "Working Formulation" for lymphoma. As such, the term lives on in the names of many conditions, even when the size of the cell is no longer one of the most important diagnostic criteria.

The phrase [giant cell](/source/giant_cell) is also frequently used, especially with [carcinoma](/source/carcinoma).

Giant cell tumors include [giant-cell tumor of bone](/source/giant-cell_tumor_of_bone), [giant-cell tumor of the tendon sheath](/source/giant-cell_tumor_of_the_tendon_sheath),<ref>{{MeshName|Giant+Cell+Tumors}}</ref> and [giant cell fibroblastoma](/source/giant_cell_fibroblastoma).<ref name="pmid32764969">{{cite journal | vauthors = Dong SS, Wang N, Yang CP, Zhang GC, Liang WH, Zhao J, Qi Y | title = Giant Cell-Rich Solitary Fibrous Tumor in the Nasopharynx: Case Report and Literature Review | journal = OncoTargets and Therapy | volume = 13 | issue = | pages = 6819–6826 | date = 2020 | pmid = 32764969 | pmc = 7367732 | doi = 10.2147/OTT.S252696 | url =  | doi-access = free }}</ref>

==See also==
{{portal|Medicine}}
* [Anaplastic large-cell lymphoma](/source/Anaplastic_large-cell_lymphoma)
* [Buttock cell](/source/Buttock_cell)
* [Massive giant-cell tumor of pelviacetabulum](/source/Massive_giant-cell_tumor_of_pelviacetabulum)
* [Nosology](/source/Nosology)

==References==
{{reflist}}

==External links==
* [http://www.mayoclinic.com/health/cancer/AN00654/FORCESSL=false& Overview] at [Mayo Clinic](/source/Mayo_Clinic)
* [https://web.archive.org/web/20050925223458/http://chemo.net/large.htm Large Cell and Giant Cell]
* {{MeshName|Carcinoma,+Giant+Cell}}

Category:Oncology

{{oncology-stub}}

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Adapted from the Wikipedia article [Large cell](https://en.wikipedia.org/wiki/Large_cell) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Large_cell?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.