# LGR6

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/LGR6
> Markdown URL: https://mediated.wiki/source/LGR6.md
> Source: https://en.wikipedia.org/wiki/LGR6
> Source revision: 1300573142
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

**Leucine-rich repeat-containing G-protein coupled receptor 6** is a [protein](/source/Protein) that in humans is encoded by the *LGR6* [gene](/source/Gene).[1][2] Along with the other [G-protein coupled receptors](/source/G_protein%E2%80%93coupled_receptor) [LGR4](/source/LGR4) and [LGR5](/source/LGR5), LGR6 is a [Wnt signaling pathway](/source/Wnt_signaling_pathway) mediator. *LGR6* also acts as an epithelial stem cell marker in [squamous cell carcinoma](/source/Squamous_cell_carcinoma) in mice *in vivo.*[3]

This gene encodes a member of the [leucine-rich repeat](/source/Leucine-rich_repeat)-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a [glycoprotein](/source/Glycoprotein) hormone receptor with a large [N-terminal](/source/N-terminal) extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for [ligand](/source/Ligand) binding. Alternative splicing of this gene results in multiple [transcript variants](/source/Transcript_variant).[2]

## References

1. Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". *Mol Endocrinol*. **14** (8): 1257–71. [doi:10.1210/me.14.8.1257](https://doi.org/10.1210/me.14.8.1257). [PMID 10935549](https://pubmed.ncbi.nlm.nih.gov/10935549)

1. ["Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=59352)

1. Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma". *Nature Genetics*. **49** (11): 1624–1632. [doi:10.1038/ng.3957](https://doi.org/10.1038/ng.3957). [PMC 5662105](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662105). [PMID 28945253](https://pubmed.ncbi.nlm.nih.gov/28945253)

## Further reading

- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". *Genome Res.*. **6** (9): 791–806. [doi:10.1101/gr.6.9.791](https://doi.org/10.1101/gr.6.9.791). [PMID 8889548](https://pubmed.ncbi.nlm.nih.gov/8889548)
- Takeda S, Kadowaki S, Haga T, etal (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". *FEBS Lett.*. **520** (1–3): 97–101. [doi:10.1016/S0014-5793(02)02775-8](https://doi.org/10.1016/S0014-5793(02)02775-8). [PMID 12044878](https://pubmed.ncbi.nlm.nih.gov/12044878). [S2CID 7116392](https://api.semanticscholar.org/CorpusID:7116392)
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Clark HF, Gurney AL, Abaya E, etal (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". *Genome Res.*. **13** (10): 2265–70. [doi:10.1101/gr.1293003](https://doi.org/10.1101/gr.1293003). [PMC 403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID 12975309](https://pubmed.ncbi.nlm.nih.gov/12975309)
- Ota T, Suzuki Y, Nishikawa T, etal (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Gregory SG, Barlow KF, McLay KE, etal (2006). "The DNA sequence and biological annotation of human chromosome 1". *Nature*. **441** (7091): 315–21. [Bibcode:2006Natur.441..315G](https://ui.adsabs.harvard.edu/abs/2006Natur.441..315G). [doi:10.1038/nature04727](https://doi.org/10.1038/nature04727). [PMID 16710414](https://pubmed.ncbi.nlm.nih.gov/16710414)

---
Adapted from the Wikipedia article [LGR6](https://en.wikipedia.org/wiki/LGR6) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/LGR6?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.